The Effect of a High-Fat Meal on Postprandial Arterial Stiffness in Men with Obesity and Type 2 Diabetes

Context: Postprandial dysmetabolism is emerging as an important cardiovascular risk factor. Augmentation index (AIx) is a measure of systemic arterial stiffness and independently predicts cardiovascular outcome. Objective: The objective of this study was to assess the effect of a standardized high-fat meal on metabolic parameters and AIx in 1) lean, 2) obese nondiabetic, and 3) subjects with type 2 diabetes mellitus (T2DM). Design and Setting: Male subjects (lean, n = 8; obese, n = 10; and T2DM, n = 10) were studied for 6 h after a high-fat meal and water control. Glucose, insulin, triglycerides, and AIx (radial applanation tonometry) were measured serially to determine the incremental area under the curve (iAUC). Results: AIx decreased in all three groups after a high-fat meal. A greater overall postprandial reduction in AIx was seen in lean and T2DM compared with obese subjects (iAUC, 2251 ± 1204, 2764 ± 1102, and 1187 ± 429% · min, respectively; P < 0.05). The time to return to baseline AIx was significantly delayed in subjects with T2DM (297 ± 68 min) compared with lean subjects (161 ± 88 min; P < 0.05). There was a significant correlation between iAUC AIx and iAUC triglycerides (r = 0.50; P < 0.05). Conclusions: Obesity is associated with an attenuated overall postprandial decrease in AIx. Subjects with T2DM have a preserved, but significantly prolonged, reduction in AIx after a high-fat meal. The correlation between AIx and triglycerides suggests that postprandial dysmetabolism may impact on vascular dynamics. The markedly different response observed in the obese subjects compared with those with T2DM was unexpected and warrants additional evaluation.

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The Effect of a High Fat Meal on Postprandial Arterial Stiffness in Obesity and Type 2 Diabetes.

10.1210/endo-meetings.2010.part2.p11.p2-524 ◽

2010 ◽

pp. P2-524-P2-524

Author(s):

LK Phillips ◽

J Peake ◽

X Zhang ◽

IJ Hickman ◽

BE Huang ◽

...

Keyword(s):

Type 2 Diabetes ◽

Arterial Stiffness ◽

High Fat ◽

Fat Meal

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Augmentation index and arterial stiffness in patients with type 2 diabetes mellitus

Artery Research ◽

10.1016/j.artres.2013.09.002 ◽

2013 ◽

Vol 7 (3-4) ◽

pp. 194 ◽

Cited By ~ 10

Author(s):

Rachel E.D. Climie ◽

Sonja B. Nikolic ◽

Petr Otahal ◽

Laura J. Keith ◽

James E. Sharman

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Arterial Stiffness ◽

Augmentation Index

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Questioning the Postprandial Inflammatory Hypothesis — Absence of Significant Inflammation and No Change in Total or High-Molecular-Weight Adiponectin after a High-Fat Meal in Obesity or Type 2 Diabetes

10.1210/endo-meetings.2011.part3.p2.p2-423 ◽

2011 ◽

pp. P2-423-P2-423

Author(s):

Liza K Phillips ◽

Jonathan M Peake ◽

Xia Zhang ◽

Ingrid J Hickman ◽

Bevan E Huang ◽

...

Keyword(s):

Type 2 Diabetes ◽

Molecular Weight ◽

High Molecular Weight ◽

High Fat ◽

High Molecular Weight Adiponectin ◽

Fat Meal

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Interaction of diet and diabetes on cardiovascular function in rats

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00421.2008 ◽

2009 ◽

Vol 296 (2) ◽

pp. H282-H292 ◽

Cited By ~ 43

Author(s):

Susan A. Marsh ◽

Louis J. Dell′Italia ◽

John C. Chatham

Keyword(s):

Type 2 Diabetes ◽

Arterial Stiffness ◽

Augmentation Index ◽

Systolic Dysfunction ◽

Young Male ◽

Wall Stress ◽

Left Ventricular ◽

Male Rats ◽

Glucose Levels

Genetic rodent models of type 2 diabetes are routinely utilized in studies of diabetes-related cardiovascular disease; however, these models frequently exhibit abnormalities that are not consistent with diabetic complications. The aim of this study was to develop a model of type 2 diabetes that exhibits evidence of cardiovascular dysfunction commonly seen in patients with diabetes with minimal nondiabetes-related pathologies. Young male rats received either control (Con), high-fat (HF; 60%), or Western (Wes; 40% fat, 45% carbohydrate) diets for 2 wk after which streptozotocin (2 × 35 mg/kg ip 24 h apart) was administered to induce diabetes (Dia). Blood glucose levels were higher in Con + Dia and Wes + Dia groups compared with the HF + Dia group (25 ± 1, 25 ± 2, and 15 ± 1 mmol/l, respectively; P < 0.05) group. Liver, kidney, and pancreatic dysfunction and cardiomyocyte lipid accumulation were found in all diabetic animals. Despite lower heart rates in Con + Dia and HF + Dia groups, arterial and left ventricular pressures were not different between any of the experimental groups. All three diabetic groups had diastolic dysfunction, but only HF + Dia and Wes + Dia groups exhibited elevated diastolic wall stress, arterial stiffness (augmentation index), and systolic dysfunction (velocity of circumferential shortening, systolic wall stress). Surprisingly, we found that left ventricular dysfunction and arterial stiffness were more pronounced in the HF + Dia than the Con + Dia group and was similar to the Wes + Dia group despite significantly lower levels of hyperglycemia compared with either group. In conclusion, the HF + Dia group exhibited a stable, modest level of hyperglycemia, which was associated with cardiac dysfunction comparable with that seen in moderate to advanced stages of human type 2 diabetes.

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Effect of alpha-lipoic acid on arterial stiffness parameters in type 2 diabetes mellitus patients with cardiac autonomic neuropathy

Endocrine Regulations ◽

10.2478/enr-2021-0024 ◽

2021 ◽

Vol 55 (4) ◽

pp. 224-233

Author(s):

Victoria A. Serhiyenko ◽

Ludmila M. Serhiyenko ◽

Volodymyr B. Sehin ◽

Alexandr A. Serhiyenko

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Arterial Stiffness ◽

Lipoic Acid ◽

Augmentation Index ◽

Cardiac Autonomic Neuropathy ◽

Alpha Lipoic Acid ◽

Hypoglycemic Therapy

Abstract Objective. Significantly underdiagnosed, diabetes-associated cardiac autonomic neuropathy (CAN) causes a wide range of cardiac disorders that may cause life-threatening outcomes. This study investigated the effects of alpha-lipoic acid (ALA) on arterial stiffness and insulin resistance (IR) parameters in type 2 diabetes mellitus (T2D) patients and definite CAN. Methods. A total of 36 patients with T2D and a definite stage of CAN were recruited. This investigation was carried out on two separate arms: traditional hypoglycemic therapy (n=18, control) and ALA (n=18) 600 mg in film-coated tablets/q.d. in addition to traditional hypoglycemic therapy. The duration of the study was three months. Results. In subjects with T2D and definite stage of СAN, treatment with ALA resulted in a significant decrease of glucose, immunoreactive insulin concentration, and Homeostasis Model Assessment (HOMA)-IR (HOMA-IR) parameters; pulse wave velocity (PWV), aorta augmentation index (AIxao) during the active period of the day and decrease of PWV, AIxao, and brachial augmentation index during the passive period of the day compared with the results, obtained in the control group. Therefore, the administration of ALA to patients with T2D for three months promotes the improvement of glucose metabolism and arterial stiffness parameters. Conclusions. In patients with T2D and definite stage of СAN treatment with ALA improved HOMA-IR and arterial stiffness parameters. These findings can be of clinical significance for the complex treatment of diabetes-associated CAN.

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The Effects of Cabergoline on Vascular Indices in Overweight and Obese Type 2 Diabetes Patients

Asian Journal of Medicine and Biomedicine ◽

10.37231/ajmb.2021.5.1.369 ◽

2021 ◽

Vol 5 (1) ◽

pp. 10-18

Author(s):

Miza Hiryanti Zakaria ◽

Wan Mohamad Wan Bebakar ◽

Aida Hanum Ghulam Rasool ◽

Zulkefli Sanip ◽

Wan Mohd Izani Wan Mohamed

Keyword(s):

Type 2 Diabetes ◽

Arterial Stiffness ◽

Lipid Profile ◽

Augmentation Index ◽

Fasting Blood Glucose ◽

Cardiovascular Complications ◽

Control Groups ◽

Profile Changes ◽

And Control

Introduction: Type 2 diabetes (T2D) and obesity often coexist and are associated with increased cardiovascular complications. Objective: This study aims to determine the effects of cabergoline, a dopamine agonist on fasting blood glucose (FBG), glycated hemoglobin (HbA1c), lipid profile, blood pressure (BP) and arterial stiffness in overweight and obese T2D patients. Methods: Fifty-eight T2D patients were randomized to cabergoline 0.5 mg biweekly or control groups for 12 weeks. BP and arterial stiffness were recorded at baseline before starting study medication and repeated after 12 weeks. Pulse wave velocity (PWV) and central augmentation index (AIx) were used to assess arterial stiffness. Other parameters measured were anthropometric measurements, FBG, HbA1c and lipid profile. Changes in these parameters after 12 weeks compared to baseline were calculated for each group, and compared between the two groups. Results: Twenty-eight and twenty-six patients from cabergoline and control groups completed the treatment respectively. After 12 weeks, weight and diastolic BP were increased for both groups while body mass index (BMI) and waist circumference (WC) were increased in cabergoline group. PWV and AIx were not significantly different either within or between group comparisons. There were no significant differences in mean changes in all parameters between the two groups. Conclusion: Weight and diastolic BP were elevated in both groups while BMI and WC were increased in cabergoline group. Compared to control, cabergoline treatment at 0.5 mg biweekly in overweight and obese T2D patients for 12 weeks did not improve BP and arterial stiffness.

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