scholarly journals Reference Ranges and Determinants of Thyroid Function During Early Pregnancy: The SELMA Study

2018 ◽  
Vol 103 (9) ◽  
pp. 3548-3556 ◽  
Author(s):  
Arash Derakhshan ◽  
Huan Shu ◽  
Maarten A C Broeren ◽  
Ralph A de Poortere ◽  
Sverre Wikström ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Population Based ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Free T4 ◽  
Serum Cotinine ◽  
Child Asthma ◽  
Mother And Child ◽  
Total Triiodothyronine ◽  
Main Determinants

Abstract Context Establishing reference ranges as well as identifying and quantifying the determinants of thyroid function during pregnancy is important for proper clinical interpretation and optimizing research efforts. However, such data are sparse, specifically for triiodothyronine measurements, and most studies do not take into account thyroid antibodies or human chorionic gonadotropin. Objective To determine reference ranges and to identify/quantify determinants of TSH, free T4 (FT4), free triiodothyronine (FT3), total T4 (TT4), and total triiodothyronine (TT3). Design, Setting, and Participants This study included 2314 participants of the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study, a population-based prospective pregnancy cohort of mother-child pairs. Reference ranges were calculated by 2.5th to 97.5th percentiles after excluding thyroperoxidase antibody (TPOAb)–positive and/or thyroglobulin antibody (TgAb)–positive women. Intervention None. Main Outcome Measures TSH, FT4, FT3, TT4, and TT3 in prenatal serum. Results After exclusion of TPOAb-positive women, reference ranges were as follows: TSH, 0.11 to 3.48 mU/L; FT4, 11.6 to 19.4 pmol/L; FT3, 3.72 to 5.92 pg/mL; TT4, 82.4 to 166.2 pmol/L; and TT3, 1.28 to 2.92 nmol/L. Additional exclusion of TgAb-positive women did not change the reference ranges substantially. Exposure to tobacco smoke, as assessed by questionnaires and serum cotinine, was associated with lower TSH and higher FT3 and TT3. Body mass index (BMI) and gestational age were the main determinants of TSH (only for BMI), FT4, FT3, TT4, and TT3. Conclusions We show that the exclusion of TgAb-positive women on top of excluding TPOAb-positive women hardly affects clinical reference ranges. We identified various relevant clinical determinants of TSH, FT4, FT3, TT4, and TT3 that could reflect endocrine-disrupting effects and/or effects on thyroid hormone transport or deiodination.

Intra- and interindividual biological variation of five analytes used in assessing thyroid function: implications for necessary standards of performance and the interpretation of results.

1986 ◽  
Vol 32 (6) ◽  
pp. 962-966 ◽  
Author(s):  
M C Browning ◽  
R P Ford ◽  
S J Callaghan ◽  
C G Fraser
Keyword(s):  
Reference Range ◽  
Population Based ◽  
Biological Variation ◽  
Reference Ranges ◽  
Hormone Concentration ◽  
Free Triiodothyronine ◽  
Mean Values ◽  
Optimal Patient Care ◽  
Total Triiodothyronine ◽  
The Mean

Abstract Intra- and interindividual components of biological variation have been determined for total thyroxin (TT4), free thyroxin (FT4), total triiodothyronine (TT3), free triiodothyronine (FT3), and thyrotropin (TSH). Calculated analytical goals (CV, %) for the precision required for optimal patient care are: TT4 less than or equal to 2.5, FT4 less than or equal to 4.7, TT3 less than or equal to 5.2, FT3 less than or equal to 3.9, and TSH less than or equal to 8.1. The marked degree of individuality demonstrated for all hormones indicates that, if conventional population-based reference ranges are used uncritically, major changes in hormone concentration may not be correctly identified for some patients because observed values continue to lie within the reference range. At analyte concentrations approximating the mean values found in this study, and for analytical performance meeting the appropriate analytical goal, the differences required for consecutive results to be significantly different (p less than or equal to 0.5) have been calculated as: TT4, 14.7 nmol/L; FT4, 5.7 pmol/L; TT3, 0.6 nmol/L; FT3, 1.3 pmol/L, and TSH, 0.7 milli-int. unit/L.

scholarly journals Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yonghong Sheng ◽  
Dongping Huang ◽  
Shun Liu ◽  
Xuefeng Guo ◽  
Jiehua Chen ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
American Thyroid Association ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Cross Sectional

Ethnic differences in the level of thyroid hormones exist among individuals. The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy. To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill. This study was performed to establish trimester-specific reference ranges of thyroid hormones in Zhuang ethnic pregnant women and explore the role of body mass index (BMI) on thyroid function. A total of 3324 Zhuang ethnic health pregnant women were recruited in this Zhuang population-based retrospective cross-sectional study. The values of thyroid stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were determined by automatic chemiluminescence immunoassay analyzer. Multivariate linear regression and binary logistic regression were constructed to evaluate the influence of BMI on the thyroid function. The established reference intervals for the serum thyroid hormones in three trimesters were as follows: TSH, 0.02–3.28, 0.03–3.22, and 0.08-3.71 mIU/L; FT4, 10.57–19.76, 10.05–19.23, and 8.96–17.75 pmol/L; FT3, 3.51–5.64, 3.42–5.42, and 2.93–5.03 pmol/L. These values were markedly lower than those provided by the manufacturers for nonpregnant adults which can potentially result in 6.10% to 19.73% misclassification in Zhuang pregnant women. Moreover, BMI was positively correlated with isolated hypothyroxinemia (OR=1.081, 95% CI=1.007–1.161), while the correlation between the BMI and subclinical hypothyroidism was not statistically significant (OR=0.991, 95% CI=0.917–1.072). This is the first study focusing on the reference ranges of thyroid hormones in Guangxi Zhuang ethnic pregnant women, which will improve the care of them in the diagnosis and treatment. We also found that high BMI was positively associated with the risk of isolated hypothyroxinemia.

scholarly journals The Relationship between Thyroid Function and Depressive Symptoms—the FIN-D2D Population-Based Study

2015 ◽  
Vol 8 ◽  
pp. CMED.S24111 ◽  
Author(s):  
Juha Saltevo ◽  
Hannu Kautiainen ◽  
Pekka Mäntyselkä ◽  
Antti Jula ◽  
Sirkka Keinänen-Kiukaanniemi ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Depressive Symptoms ◽  
Thyroid Function ◽  
Participation Rate ◽  
Population Based ◽  
Thyroid Stimulating Hormone ◽  
Free Triiodothyronine ◽  
Population Based Study ◽  
The Mean ◽  
The Relationship

The association between thyroid function and depression is controversial. Both conditions express many similar symptoms, but the studies done give conflicting results. This study draws on a random, population-based sample of 4500 subjects aged 45–75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depressive symptoms were 1.92/1.97 mU/L, 13.1/13.1 pmol/L, and 3.91/3.87 pmol/L (NS), respectively. In men, the levels were 1.87/1.94 mU/L, 13.5/13.7 pmol/L, and 4.18/4.12 pmol/L (NS), respectively. In multiple regression analysis, TSH had no relationship to BDI-21 total score. We found no association between depressive symptoms and thyroid values.

Prenatal exposure to acetaminophen and children's language development at 30 months

2018 ◽  
Vol 51 ◽  
pp. 98-103 ◽  
Author(s):  
C.-G. Bornehag ◽  
A. Reichenberg ◽  
M. Unenge Hallerback ◽  
S. Wikstrom ◽  
H.M. Koch ◽  
...  
Keyword(s):  
Language Development ◽  
Population Based ◽  
Language Delay ◽  
Urinary Concentration ◽  
Main Study ◽  
Confounding By Indication ◽  
Parental Questionnaire ◽  
Child Asthma ◽  
Mother And Child ◽  
Asthma And Allergy

AbstractObjective:To examine prenatal APAP exposure in relation to language development in offspring at 30 months of age.Method:A population-based pregnancy cohort study including 754 women who enrolled in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study in pregnancy week 8–13. Two exposure measures were used: (1) maternally reported number of APAP tablets taken between conception and enrollment; (2) APAP urinary concentration at enrollment. Language development at 30 months was assessed by nurse's evaluation and parental questionnaire, including the number of words the child used (<25, 25–50 and >50). Main study outcome; parental report of use of fewer than 50 words, termed language delay (LD).Results:59.2% of women enrolled in weeks 8–13 reported taking APAP between conception and enrollment. APAP was measurable in all urine samples and urinary APAP was correlated with the number of APAP taken during pregnancy (P<0.01). Language delay was more prevalent in boys (12.6%) than girls (4.1%) (8.5% in total). Both the number of APAP tablets and urinary APAP concentration were associated with greater LD in girls but not in boys. The adjusted odds ratio (OR) for LD among girls whose mothers reported >6vs.0 APAP tablets was 5.92 (95% confidence interval (CI) 1.10–31.94). The OR for LD in girls whose mothers’ urinary APAP was in the highest compared to the lowest quartile was 10.34 (95% CI 1.37–77.86). While it cannot be ruled out, our available data do not support confounding by indication.Conclusions:Given the prevalence of prenatal APAP use and the importance of language development, these findings, if replicated, would suggest that pregnant women should limit their use of this analgesic during pregnancy.

scholarly journals The Risk of Preeclampsia According to High Thyroid Function in Pregnancy Differs by hCG Concentration

2016 ◽  
Vol 101 (12) ◽  
pp. 5037-5043 ◽  
Author(s):  
Tim I. M. Korevaar ◽  
Eric A. P. Steegers ◽  
Layal Chaker ◽  
Marco Medici ◽  
Vincent W. V. Jaddoe ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Outcome Measure ◽  
High Body Mass Index ◽  
Population Based ◽  
Additional Measurement ◽  
Free T4 ◽  
Normal Thyroid Function ◽  
General Community ◽  
Risk Of Preeclampsia

Context: During pregnancy, there is an increased demand for thyroid hormone. The pregnancy hormone human chorionic gonadotropin (hCG) is an important physiological stimulator of thyroid function. Already high-normal maternal free T4 concentrations are associated with a higher risk of preeclampsia. Objective: The objective of the investigation was to study our hypothesis that hCG concentrations can distinguish a physiological form of high thyroid function from a more pathological form of high thyroid function and that the risk of preeclampsia would differ accordingly. Design: TSH, free T4, hCG, or thyroperoxidase antibody concentrations were determined in pregnant women participating in a population-based prospective cohort study. Setting: The study was conducted in the general community. Participants: A nonselected sample of 5146 pregnant women participated in the study. Interventions: There were no interventions. Main Outcome Measure(s): Preeclampsia was measured. Results: Women with high hCG-associated high thyroid function did not have a higher risk of preeclampsia than women with normal thyroid function. In contrast, women with low hCG and high thyroid function had a 3.4- to 11.1-fold higher risk of preeclampsia. These risk estimates were amplified in women with a high body mass index. Women with a low hCG and suppressed TSH (&lt;0.10 mU/L) had a 3.2- to 8.9-fold higher risk of preeclampsia. hCG was not associated with preeclampsia, and results remained similar after exclusion of thyroperoxidase antibody-positive women. Conclusion: This study suggests that, in contrast to women with a high hCG associated high thyroid function, women with low hCG and high thyroid function during pregnancy are at a higher risk of developing preeclampsia. The additional measurement of hCG may therefore help to distinguish a more pathological form of high thyroid function and women at a high risk of preeclampsia.

Changes in Thyroid Function Across Adolescence: A Longitudinal Study

2020 ◽  
Vol 105 (4) ◽  
pp. e1162-e1170 ◽  
Author(s):  
Purdey J Campbell ◽  
Suzanne J Brown ◽  
Phillip Kendrew ◽  
Michelle Lewer ◽  
Ee Mun Lim ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Twin Study ◽  
Specific Reference ◽  
Sexually Dimorphic ◽  
Reference Ranges ◽  
Thyroid Function Tests ◽  
Longitudinal Analyses ◽  
Free Triiodothyronine ◽  
Longitudinal Twin Study ◽  
Abbott Architect

Abstract Objective There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in thyrotropin (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and determine age-specific reference ranges. Methods Thyroid function was assessed in 3415 participants in the Brisbane Longitudinal Twin Study at ages 12, 14, and 16, using the Abbott ARCHITECT immunoassay. Longitudinal analyses were adjusted for body mass index and puberty. Results In girls, mean fT4 (± SE) increased between age 12 and 14 (by 0.30 ± 0.08 pmol/L; P &lt; 0.001), while remaining unchanged in boys; from age 14 to 16, fT4 increased in both girls (by 0.42 ± 0.07 pmol/L; P &lt; 0.001) and boys (0.64 ± 0.07 pmol/L, P &lt; 0.001). There was a slight increase in fT3 from age 12 to 14 years in girls (by 0.07 ± 0.03 pmol/L; P = 0.042), with a more marked increase in boys (0.29 ± 0.03 pmol/L; P &lt; 0.001), followed by a decrease from age 14 to 16 in both sexes (girls, by 0.53 ± 0.02 pmol/L; P &lt; 0.001; boys, by 0.62 ± 0.03 pmol/L; P &lt; 0.001). From age 12 to 14, TSH showed no significant change in girls or boys, then levels increased from age 14 to 16 in both sexes (in girls, by 4.9%, 95% CI: 2.4%-10.3%, P = 0.020; in boys, by 7.2%, 95% CI: 3.0%-11.6%, P = 0.001). Reference ranges differed substantially from adults, particularly for fT4 and fT3. Conclusions Thyroid function tests in adolescents display complex, sexually dimorphic patterns. Implementation of adolescence-specific reference ranges may be appropriate.

Population-specific reference values for thyroid hormones on the Abbott ARCHITECT i2000 analyzer

2004 ◽  
Vol 42 (5) ◽  
Author(s):  
Manuel González-Sagrado ◽  
Francisco Javier Martín-Gil
Keyword(s):  
Thyroid Hormones ◽  
Reference Values ◽  
Patient Population ◽  
Laboratory Data ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Total Triiodothyronine ◽  
Abbott Architect

AbstractReliable reference ranges are important in the interpretation of laboratory data, and it is incumbent on each laboratory to verify that the ranges they use are appropriate for the patient population they serve. The objective of this study was to determine population-specific reference ranges for thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3) and total triiodothyronine (TT3) on the Abbott ARCHITECT

scholarly journals Total and free iodothyronines profile in the donkey (Equus asinus) over a 12-month period

2012 ◽  
Vol 81 (3) ◽  
pp. 239-244 ◽  
Author(s):  
Esterina Fazio ◽  
Pietro Medica ◽  
Cristina Cravana ◽  
Adriana Ferlazzo
Keyword(s):  
Thyroid Function ◽  
Jugular Vein ◽  
Physiological State ◽  
Reproductive Activity ◽  
Free Triiodothyronine ◽  
Blood Samples ◽  
Hormonal Profile ◽  
Equus Asinus ◽  
Total Triiodothyronine ◽  
Total Thyroxine

Several studies show the correlation between thyroid function and reproductive activity in horses, but no data are available in donkeys. The aim of this study was to determine physiological thyroid changes occurring in 10 pregnant and 14 barren donkeys over a period of 12 months. Blood samples were collected monthly from the jugular vein of pregnant and barren donkeys from June 2008 to June 2009. No significant differences (P < 0.05) in iodothyronine concentrations were observed between pregnant and barren donkeys in the same month. Seasonal total thyroxine (T4) and free triiodothyronine (fT3) patterns remained unmodified, regardless of physiological state, with the lowest T4 levels at September and the highest at February, and the lowest fT3 levels at June and the highest at July, in both pregnant and barren donkeys. Ranges of total triiodothyronine (T3) concentrations in pregnant donkeys over a 12 months period ranged from 1.57 to 2.90 nmol/l, T4 from 31.01 to 63.67 nmol/l, fT3 from 3.15 to 15.52 pmol/l and free thyroxine (fT4) from 22.47 to 33.69 pmol/l. Mean T3 concentrations in barren donkeys over a 12 months period ranged from 1.64 to 3.37 nmol/l, T4 from 42.95 nmol/l and 61.90 nmol/l, fT3 from 3.15 to 11.19 pmol/l and fT4 from 25.46 to 35.06 pmol/l. This is the first study that provided a seasonal thyroid hormonal profile in healthy barren and pregnant donkeys.

Long term changes in serum T4, T3, and TSH in benign thyroid disease

2004 ◽  
Vol 43 (05) ◽  
pp. 158-160 ◽  
Author(s):  
F. Hartmann ◽  
R. Rödel ◽  
M. Reinhardt ◽  
H.-J. Biersack
Keyword(s):  
Thyroid Function ◽  
Small Variation ◽  
Reference Ranges ◽  
Thyroid Function Tests ◽  
Free T4 ◽  
Wide Range ◽  
Serum T4 ◽  
The Individual ◽  
Benign Thyroid

Summary:Aim: The diagnosis of abnormalities of thyroid function is generally based on the measurement of thyroid hormones and TSH in blood. The recommended reference ranges for serum T4 and T3 as well as TSH are quite wide as the result of large differences in thyroid function tests in healthy persons. It has been proven that the individual variation within an individual is small, compared with the variation between individuals. We investigated long term variations of these parameters in patients with and without benign thyroid diseases. Methods: We performed long term follow-up serum determinations of T3, T4, and TSH in a total of 150 patients for a time period of 3 to 13 years. The majority of patients had been put on L-thyroxine. Values of total T3, total T4, free T4 were measured with an almost unmodified test (RIA) over the years. Results: The lowest relative coefficient of variation (<10%) was observed in the group of patients who had been treated with L-thyroxine only. Even for TSH, relatively low cofficients of variation were observed in this group. In the group of patients who had not received any medication, T3 and T4 showed also a variation of 10%. FT4 and TSH revealed a wider range of variation. Even after radioiodine therapy, T3 and T4 showed only a quite small variation, while TSH demonstrated a wide range with a variation of >30%. Conclusion: Our data demonstrate that there are only narrow variations of serum T4 and T3 within individuals with and without thyroid disorders.

scholarly journals Clinical Evaluation of Various Thyroid Hormones on Thyroid Function

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Hong Li ◽  
Xiaolan Yuan ◽  
Lu Liu ◽  
Jiaojiao Zhou ◽  
Chunyan Li ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Function ◽  
Pearson Correlation ◽  
Healthy Population ◽  
Healthy Individuals ◽  
Clinical Value ◽  
Free Triiodothyronine ◽  
Important Indicator ◽  
Total Triiodothyronine ◽  
Total Thyroxine

To clarify the clinical value of serums total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) and provide a more eligible and economic strategy to assess thyroid function. A total of 2,673 participants (500 patients with hyperthyroidism, 500 patients with hypothyroidism, and 1,673 healthy people) were involved in our study. Serums TT3, TT4, FT3, and FT4 and thyrotropin (TSH) were measured with VIDAS fluorescent enzyme immunoassay. The Pearson correlation between TT3, TT4, FT3, and FT4 and TSH was determined to identify the most important indicator for thyroid function besides TSH. The correlation of TT4, and FT4 with TSH was statistically significant in healthy individuals (P< 0.01), and theR-values were −0.065 and −0.152, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hyperthyroidism, and theR-values were −0.241, −0.225, −0.195, and −0.176, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hypothyroidism, and theR-values were −0.322, −0.262, −0.179, and −0.136, respectively. In our opinion, TSH and FT4 are the most valuable indicators in assessing thyroid function in a healthy population, and TSH and TT4 are the most meaningful in hyperthyroidism and hypothyroidism.

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