The interaction of a type A retroviral particle and class II human leukocyte antigen susceptibility genes in the pathogenesis of Graves' disease

1996 ◽  
Vol 81 (6) ◽  
pp. 2271-2279 ◽  
Author(s):  
J. B. Jaspan
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Type A ◽  
Class Ii ◽  
Susceptibility Genes ◽  
Graves Disease ◽  
Leukocyte Antigen

scholarly journals Binding of Human Thyrotropin Receptor Peptides to a Graves’ Disease-Predisposing Human Leukocyte Antigen Class II Molecule

2000 ◽  
Vol 85 (3) ◽  
pp. 1176-1179 ◽  
Author(s):  
Yoshikuni Sawai ◽  
Leslie J. DeGroot
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Graves Disease ◽  
T Cell Repertoire ◽  
Thyrotropin Receptor ◽  
Cell Repertoire ◽  
Peptide Epitopes ◽  
Leukocyte Antigen

Abstract Abstract There are many reports that Graves’ disease (GD) is associated with certain human leukocyte antigen (HLA) molecules, in particular DR3. Here we examined the characteristics of binding of human TSH receptor (TSHR) peptides to this disease-associated HLA class II molecule. DR3 molecules bind TSHR immuonodominant peptide epitopes with intermediate affinity. On the contrary, DR3 binds nonimmunogenic peptides either with poor affinity or not at all, with one exceptional peptide that has extremely high affinity. These results suggest that susceptibility to GD associated with inheritance of a specific HLA class II gene is due to the influence of the HLA molecule-TSHR peptide complex on the T cell repertoire.

scholarly journals Regression Mapping of Association between the Human Leukocyte Antigen Region and Graves Disease

2005 ◽  
Vol 76 (1) ◽  
pp. 157-163 ◽  
Author(s):  
Matthew J. Simmonds ◽  
Joanna M.M. Howson ◽  
Joanne M. Heward ◽  
Heather J. Cordell ◽  
Helen Foxall ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Graves Disease ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen Region ◽  
Regression Mapping

Mechanisms and Effects of Loss of Human Leukocyte Antigen Class II Expression in Immune-Privileged Site-Associated B-Cell Lymphoma

2006 ◽  
Vol 12 (9) ◽  
pp. 2698-2705 ◽  
Author(s):  
Marije Booman ◽  
Jenny Douwes ◽  
Annuska M. Glas ◽  
Sietske A. Riemersma ◽  
Ekaterina S. Jordanova ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
B Cell ◽  
Human Leukocyte Antigen Class ◽  
Cell Lymphoma ◽  
Human Leukocyte ◽  
B Cell Lymphoma ◽  
Class Ii ◽  
Leukocyte Antigen ◽  
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