Effect of Pyrogen on Blood Levels of Pituitary Trophic Hormones. Observations of the Usefulness of the Growth Hormone Response in the Detection of Pituitary Disease

1967 ◽  
Vol 27 (2) ◽  
pp. 219-226 ◽  
Author(s):  
PETER O. KOHLER ◽  
BERT W. O'MALLEY ◽  
PHILLIP L. RAYFORD ◽  
MORTIMER B. LIPSETT ◽  
WILLIAM D. ODELL
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Response ◽  
Blood Levels ◽  
Hormone Response ◽  
Pituitary Disease ◽  
Trophic Hormones

An audit of the laboratory interpretation of growth hormone response to insulin-induced hypoglycaemia in the assessment of short stature in children

2003 ◽  
Vol 40 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Andrew Ellis ◽  
John Seth ◽  
Ruth Al-Sadie ◽  
Julian H Barth
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Gh Deficiency ◽  
Stress Test ◽  
Growth Hormone Response ◽  
Hormone Response ◽  
Serum Growth Hormone ◽  
Pituitary Disease ◽  
Interpretation Of Results

Introduction: Measurement of serum growth hormone (GH) concentration in response to insulin-induced hypoglycaemia remains an important investigation in the assessment of pituitary disease. Methods In this audit, laboratories were presented with aliquots of sera with GH concentrations likely to be found in an insulin stress test (IST). They were invited to analyse the specimens for GH and comment on their results. Results and discussion: A number of laboratories appeared to be using out-of-consensus cut-off concentrations that sometimes were unrelated to the bias of their GH assay. The specimens were chosen to mimic those seen in an IST that was clearly not indicative of GH deficiency, so there was reasonable consensus in the interpretation of results. However, five laboratories (9·6%) did indicate that their results were equivocal.

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