Alterations in Systolic Time Intervals in Primary Hypothyroidism as a Consequence of Warming

1983 ◽  
Vol 56 (1) ◽  
pp. 185-188 ◽  
Author(s):  
B. NORTHOVER ◽  
B.P. O'MALLEY ◽  
F.D. ROSENTHAL
1994 ◽  
Vol 22 (5) ◽  
pp. 273-277 ◽  
Author(s):  
J Taylor ◽  
B O Williams ◽  
J Frater ◽  
D J Stott ◽  
J Connell

Seven female patients (mean age 86 years) with proven biochemical primary hypothyroidism were enrolled in a single-blind randomized crossover study, of standard daily versus twice-weekly thyroxine therapy, with each phase of one month's duration. The median daily dose of thyroxine was 100 μg (range 75 – 100 μg). Serum levels of thyroid hormones and thyrotrophin were very similar during twice-weekly thyroxine therapy to those during daily therapy and there were no statistically significant differences between trough and peak serum total triiodothyronine, free thyroxine, or thyrotrophin levels or systolic time intervals during twice-weekly thyroxine. Administration of thyroxine twice-weekly to elderly patients with primary hypothyroidism gives effective biochemical thyroid hormone replacement, with no evidence from the systolic time intervals of tissue thyrotoxicosis at expected peak thyroid hormone concentrations. Supervised twice-weekly thyroxine should be considered in patients with primary hypothyroidism who comply poorly with daily dosing.


CHEST Journal ◽  
1982 ◽  
Vol 81 (5) ◽  
pp. 660 ◽  
Author(s):  
George Louridas ◽  
Demetrios Patakas ◽  
Nicholas Galanis ◽  
Marianna Kakoura ◽  
Costas Stavropoulos

1978 ◽  
Vol 55 (s4) ◽  
pp. 65s-68s ◽  
Author(s):  
D. Cousineau ◽  
J. de Champlain ◽  
L. Lapointe

1. Average supine circulating total catecholamine concentrations were found to be higher than the normal range in about 50% of patients with labile hypertension and in about 30% of patients with sustained essential hypertension. 2. These higher resting concentrations were mainly due to an increase in adrenaline in labile hypertension and to an increase in noradrenaline in sustained hypertension. 3. Patients with elevated catecholamine concentrations were also characterized by a higher heart rate, by an increased myocardial contractility and by greater hypotensive response after treatment with β-adrenoreceptor blocking agents. 4. These studies suggest the existence of subgroups of hypertensive patients with increased sympathetic tone.


Heart ◽  
1981 ◽  
Vol 46 (1) ◽  
pp. 74-79 ◽  
Author(s):  
G G Sandor ◽  
M W Patterson ◽  
M Tipple ◽  
D J Vince

Circulation ◽  
1974 ◽  
Vol 50 (2) ◽  
pp. 317-323 ◽  
Author(s):  
JOSEPH S. ALPERT ◽  
FRANK D. RICKMAN ◽  
JOHN P. HOWE ◽  
LEWIS DEXTER ◽  
JAMES E. DALEN

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