Plasminogen activator activity during decidualization of human endometrial stromal cells is regulated by plasminogen activator inhibitor 1.

1995 ◽  
Vol 80 (8) ◽  
pp. 2504-2510
Author(s):  
F Schatz ◽  
S Aigner ◽  
C Papp ◽  
E Toth-Pal ◽  
V Hausknecht ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Stromal Cells ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Endometrial Stromal Cells ◽  
Plasminogen Activator Activity ◽  
Activator Inhibitor

scholarly journals Sex Steroids Regulate the Expression of Plasminogen Activator Inhibitor-1 and its mRNA in Fibroblasts Derived from Uterine Endometrium

1996 ◽  
Vol 33 (6) ◽  
pp. 545-550 ◽  
Author(s):  
Jiro Fujimoto ◽  
Masashi Hori ◽  
Satoshi Ichigo ◽  
Teruhiko Tamaya
Keyword(s):  
Plasminogen Activator ◽  
Stromal Cells ◽  
Sex Steroids ◽  
Plasminogen Activator Inhibitor ◽  
Tissue Type ◽  
Endometrial Stromal Cells ◽  
Uterine Endometrium ◽  
Type Plasminogen Activator ◽  
Activator Inhibitor ◽  
Pai 1

In order to clarify a role of stromal cells in sex steroidal neovascularization, plasminogen activator inhibitor (PAI)-1 [an inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA)] and its messenger ribonucleic acid (mRNA) were analysed in fibroblasts derived from uterine endometrium as a model for endometrial stromal cells under the influence of sex steroids. The determinations were carried out by an enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction-Southern blotting, respectively. In the fibroblasts, either estradiol or progestogens (progesterone, medroxy progesterone acetate or 17α-hydroxyprogesterone) induced expressions of PAI-1 and its mRNA, and their combination further increased their expression by approximately twofold. PAI-1 from endometrial stromal cells under the influence of sex steroids might contribute to endometrial neovascularization through its effect on endothelial cells in endometrial vessels.

scholarly journals Improved Autograft Survival of Mesenchymal Stromal Cells by Plasminogen Activator Inhibitor 1 Inhibition

Stem Cells ◽  
2009 ◽  
Vol 27 (2) ◽  
pp. 467-477 ◽  
Author(s):  
Ian B. Copland ◽  
Simon Lord-Dufour ◽  
Jessica Cuerquis ◽  
Daniel L. Coutu ◽  
Borhane Annabi ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Activator Inhibitor
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