Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine

2003 ◽  
Vol 55 (7) ◽  
pp. 963-972 ◽  
Author(s):  
Sofia Berggren ◽  
Pernilla Lennernäs ◽  
Mats Ekelund ◽  
Björn Weström ◽  
Janet Hoogstraate ◽  
...  
1993 ◽  
Vol 34 (2) ◽  
pp. 331-339
Author(s):  
D.D. Sviridov ◽  
I.G. Safonova ◽  
J.L. Nano ◽  
M.Y. Pavlov ◽  
P Rampal ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Diogo Martins ◽  
Michael A. DiCandia ◽  
Aristides L. Mendes ◽  
Daniela Wetzel ◽  
Shonna M. McBride ◽  
...  

AbstractBacteria that reside in the gastrointestinal tract of healthy humans are essential for our health, sustenance and well-being. About 50–60% of those bacteria have the ability to produce resilient spores that are important for the life cycle in the gut and for host-to-host transmission. A genomic signature for sporulation in the human intestine was recently described, which spans both commensals and pathogens such as Clostridioides difficile and contains several genes of unknown function. We report on the characterization of a signature gene, CD25890, which, as we show is involved in the control of sporulation initiation in C. difficile under certain nutritional conditions. Spo0A is the main regulatory protein controlling entry into sporulation and we show that an in-frame deletion of CD25890 results in increased expression of spo0A per cell and increased sporulation. The effect of CD25890 on spo0A is likely indirect and mediated through repression of the sinRR´ operon. Deletion of the CD25890 gene, however, does not alter the expression of the genes coding for the cytotoxins or the genes involved in biofilm formation. Our results suggest that CD25890 acts to modulate sporulation in response to the nutrients present in the environment.


2002 ◽  
Vol 36 (8) ◽  
pp. 1349-1361 ◽  
Author(s):  
Gotzon Gangoiti ◽  
Lucio Alonso ◽  
Marino Navazo ◽  
Amaia Albizuri ◽  
Gorka Perez-Landa ◽  
...  

2021 ◽  
Vol 13 (11) ◽  
pp. 5947
Author(s):  
Pedro Plasencia-Lozano

Some relevant transport infrastructures are expected to be built in Extremadura, a Spanish region. Future investments could transform the regional transportation system and therefore could act as an important lever for economic and social change. The text describes the current situation and also the planned infrastructures, and an ex ante study is developed. The research has set the deficiencies of Extremadura in terms of transportation network, but current planning proves that the rail and airport infrastructures in Extremadura are set to involve a significant change of model. Moreover, the importance of taking into consideration the transport planning documents of neighboring countries in the transport analysis of bordering regions and the negative consequence of designing national and regional transport plans without considering the neighboring plans have been described.


2021 ◽  
Vol 293 ◽  
pp. 112827
Author(s):  
Ishaq Dimeji Sulaymon ◽  
Yuanxun Zhang ◽  
Jianlin Hu ◽  
Philip K. Hopke ◽  
Yang Zhang ◽  
...  

2010 ◽  
Author(s):  
Junming Wang ◽  
Ted W Sammis ◽  
David R Miller ◽  
David Granucci ◽  
April L Hiscox ◽  
...  
Keyword(s):  

1970 ◽  
Vol 52 (1) ◽  
pp. 14 ◽  
Author(s):  
G. A. James ◽  
A. D. Cliff ◽  
P. Haggett ◽  
J. K. Ord

2013 ◽  
Vol 6 (2) ◽  
Author(s):  
Olabisi Delebayo Akinkugbe

AbstractWith regional economic integration (REI) as a major strategy for development, the African continent hosts a plethora of regional economic communities of varying ambition longevity and success. While in the 1970s, political-economic ideas built mainly on the “developmental state” informed the design of most of these agreements, the change in economic thought in the 1980s which ushered in the “neoliberal turn” has since influenced the design of most REI schemes in Africa, including the New Partnership for African Development. However, among other factors, inadequate transport infrastructure linking regions poses a major impediment to regional trade and development in Africa. The more so as most African governments are not able to meet up with the financial burden, pace and managerial capability for the efficient provision and management of regional transport infrastructure. The article explores the dilemma associated with the adoption of Public–Private Partnerships (“PPP”) as a mechanism for the provision of regional transport infrastructure in Africa. While sourcing infrastructure provision through the PPP mechanism has significant advantages, it is however also embedded with a complex financial, contractual and legal process. First, it explores the theoretical assumptions which inform PPP based on ideologies within law and development debates. It argues that theoretically, PPPs are reflective of the neoliberal policy set. Against the trajectory of governance in Africa, it critically foregrounds insights that are derivable from an application of Path Dependency theory to the institutional change which comes with the planned adoption of PPP at the regional level. These insights are essential considerations for policy experts to bear in mind both while designing the regional institutional framework for PPP and during the implementation stage. Secondly, although most of the past initiatives for the provision of regional infrastructure have fallen short of their flamboyant development policy goals, the article argues that the recently initiated Programme for Infrastructure Development in Africa (“PIDA”) provides a new hope for the future of infrastructure development in the continent. The article contends that PIDA offers a legitimate platform which with the requisite support of the regional economic initiatives can generate the enabling environment for the implementation of successful regional PPP infrastructure projects.


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