scholarly journals Immediate reactions with glatiramer acetate

2019 ◽  
Vol 10 (2) ◽  
pp. 170-177
Author(s):  
Guadalupe Marco-Martín ◽  
Pilar Tornero ◽  
Alicia Prieto ◽  
Alejandro La Rotta ◽  
Teresa Herrero ◽  
...  
Keyword(s):  
Glatiramer Acetate ◽  
Adverse Reactions ◽  
Clinical Evidence ◽  
Specific Ige ◽  
Accurate Diagnosis ◽  
Allergy Diagnosis ◽  
Close Collaboration ◽  
Intradermal Tests ◽  
Rule Out

Purpose of reviewDiverse adverse events have been associated with administration of glatiramer acetate (GA), mainly local reactions at the injection site. Other, less frequent generalized reactions include isolated postinjection reactions and anaphylaxis, which may lead to discontinuation of GA.Recent findingsClose collaboration between the allergy and neurology departments is needed to study adverse reactions to GA. The allergy study should include a detailed history and skin prick and intradermal tests with GA and, if possible, determination of specific IgE levels. Furthermore, the implication of other drugs should be ruled out.SummaryAn accurate diagnosis of reactions to GA is essential if we are to confirm or rule out allergy to GA. When an allergy diagnosis is confirmed or firmly suspected based on clinical evidence, desensitization protocols are increasingly seen as safe methods for reintroduction of GA.

scholarly journals The Rare Case of a Probably True IgE-Mediated Allergy to Local Anaesthetics

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Christina Fellinger ◽  
Felix Wantke ◽  
Wolfgang Hemmer ◽  
Gabriele Sesztak-Greinecker ◽  
Stefan Wöhrl
Keyword(s):  
Adverse Reactions ◽  
Skin Prick Testing ◽  
Local Anaesthetics ◽  
Specific Ige ◽  
Exceptional Case ◽  
Serum Tryptase ◽  
Normal Range ◽  
Intradermal Testing ◽  
Ige Mediated ◽  
Rule Out

The majority of immediate type adverse reactions to local anaesthetics seem to be non-IgE-mediated. We report a case of a 31-year-old woman, who developed conjunctivitis and conjunctival erythema immediately after intrauterine application of a local anaesthetic. Skin prick testing and intradermal testing were done with lidocaine, mepivacaine, and procaine. Intradermal testing showed positive reactions to mepivacaine (1 : 10), undiluted lidocaine, and procaine (1 : 10 and undiluted). Specific IgE could be detected against mepivacaine, but not against latex. Serum tryptase was in the normal range. In order to rule out the exceptional case of a true IgE-mediated reaction, allergy testing with local anaesthetics is still required in the workup of patients.

scholarly journals The Importance of Diet in Predicting the Remission of Urticaria—Determination of Allergen-Specific IgE

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 679
Author(s):  
Monica Iuliana Ungureanu ◽  
Liliana Sachelarie ◽  
Radu Ciorap ◽  
Bogdan Aurelian Stana ◽  
Irina Croitoru ◽  
...  
Keyword(s):  
Predictive Value ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Egg White ◽  
Food Allergens ◽  
Pediatric Hospital ◽  
Disease Remission ◽  
Specific Serum ◽  
Different Types

Background and Objectives: Different types of food introduced gradually in the diet will expose children to different food allergens, increasing the chance of developing allergic diseases. The aim of our study was to determine if allergen-specific IgE values can influence, depending on the diet, the prediction of remission of urticaria in children. Materials and Methods: This prospective study was conducted in 132 patients diagnosed over two years with urticaria, admitted to “Sf. Maria” Clinical Pediatric Hospital Iaşi. Total IgE assay was performed by ELISA, and determination of specific serum IgE by the CLA System Quanti Scan method (Innogenetics, Heiden, Germany). Data were gathered and statistical analysis was performed using statistical software SPSS, using descriptive and inferential statistics. Results: The determination of specific IgE to food allergens was performed on a total of 132 cases. The values of specific IgE were positive for one or more food allergens in 84 patients (63.64%). The most common allergens involved were: cow’s milk in 33.3% cases, egg white in 22.6% cases, and hazelnuts in 11.9% cases. The specific IgE values for the different types of food included in our study had a predictive value for disease remission. Conclusions: The determination of specific IgE confirms the presence of a particular food allergen and may have predictive value for the future development of an allergic manifestation.

scholarly journals CLINICAL SIGNIFICANCE OF DETERMINATION OF IGE ANTIBODIES TO STAPHYLOCOCCUS AUREUS AND MALASSEZIA SPECIES IN SERUM OF CHILDREN WITH ATOPIC DERMATITIS

2018 ◽  
Vol 63 (4) ◽  
pp. 84-88
Author(s):  
T. S. Okuneva ◽  
M. V. Kushnareva ◽  
A. N. Pampura ◽  
E. E. Varlamov ◽  
N. G. Konyukova
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Clinical Significance ◽  
Specific Ige ◽  
Frequency Of Occurrence ◽  
Ige Antibodies ◽  
Malassezia Species ◽  
Specific Ige Antibodies ◽  
Malassezia Spp

We studied the frequency of occurrence and concentration of allergen-specific IgE antibodies (asIgE) to enterotoxins A, B, C and TSST-1 of Staphylococcus aureus and Malassezia spp. in the serum of children with atopic dermatitis in the acute period of the disease. The determination of asIgE levels was performed in 84 children aged from 5 months to 17 years using the immunochemiluminescent method on the UniCAP 100 analyzer (Phadia, Sweden). The level of asIgE was evaluated on a scale of 6 classes.The sensitization to S. aureus enterotoxins was detected in 29 children with аsIgE concentration from 0.35 to 25.8 kU/L (I–IV classes). In 16 children were observed 8 polysensitization options to S. aureus allergens. Combinations of asIgE to A + B and A + B + C enterotoxins were most common – in every fourth and fifth child,respectively. Sensitization to Malassezia spp. was observed in 41 children with concentration from 0.38 to 98.9 KU/L (I–V classes). Polysensitization to both S. aureus and Malassezia spp. allergens was observed in one of two children. A higher degree of sensitisation to Malassezia spp allergens has been established compared to S. aureus.Conclusion. To improve the specific diagnostics of atopic dermatitis, it is advisable to examine the serum for a complete panel of recombinant S. aureus enterotoxins in combination with the determination of asIgE to Malassezia spp. 

scholarly journals Isolation of Mucorales from biological environment and identification of Rhizopus among the isolates using PCRRFLP

2019 ◽  
Vol 21 (2) ◽  
pp. 98-103
Author(s):  
Mahboobeh Madani ◽  
Mohammadali Zia
Keyword(s):  
Reliable Method ◽  
Enzymatic Digestion ◽  
Accurate Diagnosis ◽  
Molecular Methods ◽  
Clinical Samples ◽  
Molecular Approaches ◽  
Pcr Products ◽  
Microscopic Studies ◽  
Biological Environment

Background and aims: Mucorales are fungi belonging to the category of Zygomycetes, found much in nature. Culture-based methods for clinical samples are often negative, difficult and time-consuming and mainly identify isolates to the genus level, and sometimes only as Mucorales. Therefore, applying fast and accurate diagnosis methods such as molecular approaches seems necessary. This study aims at isolating Mucorales for determination of Rhizopus genus between the isolates using molecular methods. Methods: In this descriptive observational study, a total of 500 samples were collected from air and different surfaces and inoculated on Sabouraud Dextrose Agar supplemented with chloramphenicol. Then, the fungi belonging to Mucorales were identified and their pure culture was provided. DNA extraction was done using extraction kit and the chloroform method. After amplification, the samples belonging to Mucorales were identified by observing 830 bp bands. For enzymatic digestion, enzyme BmgB1 was applied for identification of Rhizopus species by formation of 593 and 235 bp segments. Results: One hundred pure colonies belonging to Mucorales were identified using molecular methods and after enzymatic digestion, 21 isolates were determined as Rhizopus species. The sequencing of PCR products and macroscopic and microscopic studies confirmed the existence of R. stolonifera, R. oryzae and R. caespitosus in the samples. Conclusion: Generally, developing a reliable method for determining Zygomycete species can be a useful tool for better understanding of the epidemiology of mucoromycosis.

Determination of early pregnancy

1935 ◽  
Vol 31 (2) ◽  
pp. 279-279
Author(s):  
I. Danilov
Keyword(s):  
Ectopic Pregnancy ◽  
Early Pregnancy ◽  
Accurate Diagnosis ◽  
To Receive

The author, recognizing the Zondek-Aschheim'a reaction extremely valuable for determining early pregnancy, considers its length of time to receive a response (100 hours) to be a great disadvantage, and therefore it is not very suitable in cases where it is required to quickly achieve an accurate diagnosis (ectopic pregnancy).

scholarly journals Nonlinear features of equatorial baroclinic Rossby waves detected in Topex altimeter observations

1996 ◽  
Vol 3 (2) ◽  
pp. 115-126 ◽  
Author(s):  
R. E. Glazman ◽  
A. Fabrikant ◽  
A. M. Greysukh
Keyword(s):  
Rossby Waves ◽  
Propagation Speed ◽  
Altimeter Data ◽  
Satellite Altimeter ◽  
Wave Regime ◽  
Nonlinear Features ◽  
Wavenumber Spectrum ◽  
Satellite Altimeter Data ◽  
Rule Out

Abstract. Using a recently proposed technique for statistical analysis of non-gridded satellite altimeter data, regime of long equatorially-trapped baroclinic Rossby waves is studied. One-dimensional spatial and spatiotemporal autocorrelation functions of sea surface height (SSH) variations yield a broad spectrum of baroclinic Rossby waves and permit determination of their propagation speed. The 1-d wavenumber spectrum of zonal variations is given by a power-law k-2 on scales from about 103 km to 104 km. We demonstrate that the observed wave regime exhibits features of soliton turbulence developing in the long baroclinic Rossby waves. However, being limited to second statistical moments, the present analysis does not allow us to rule out a possibility of weak wave turbulence.

Adverse Reactions (AR) during milk Oral Immunotherapy (mOIT) and its Relationship with specific IgE (sIgE) in 105 Milk-allergic Patients

2011 ◽  
Vol 127 (2) ◽  
pp. AB29-AB29 ◽  
Author(s):  
S. Sanchez-Garcia ◽  
C. Escudero ◽  
P. Rodriguez del Rio ◽  
C. Garcia-Fernandez ◽  
C. Ortega-Casanueva ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Specific Ige ◽  
Oral Immunotherapy

scholarly journals Ankle Synovial Chondromatosis: case report of 2 cases with 139 and 12 lose bodies treated arthroscopically

2017 ◽  
Vol 07 (03) ◽  
pp. 049-053 ◽  
Author(s):  
M. Shantharam Shetty ◽  
M. Ajith Kumar ◽  
Yogesh K. ◽  
Karan Doshi
Keyword(s):  
Case Report ◽  
Clinical Evidence ◽  
Synovial Chondromatosis ◽  
Arthroscopic Treatment ◽  
Easy Access ◽  
Loose Bodies ◽  
Early Return ◽  
Cartilaginous Lesion ◽  
Secondary Causes ◽  
Rule Out

AbstractSynovial chondromatosis is an uncommon, benign neoplastic nodular cartilaginous lesion of the synovium that can lead to lose bodies and arthritic degeneration if left untreated. We report the case of 2 patients with primary Synovial chondromatosis of the ankle with 139 and 12 loose bodies, respectively, who were treated arthroscopically. Both patients had successful outcomes without recurrence or malignancy, after excision of the lesions. We have reported the highest number of loose bodies (i.e. 139) in the ankle extracted arthroscopically. To conclude, Synovial chondromatosis, although benign, needs detailed investigations to rule out secondary causes and timely intervention to prevent further consequences. Arthroscopic treatment provides easy access and allows early return to activities. Level of clinical evidence: 4- Case Report.

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