Ocular flutter in acute doxylamine intoxication

2020 ◽  
pp. 10.1212/CPJ.0000000000000956
Author(s):  
Diana Z. Li ◽  
Zoё R. Williams ◽  
Nicholas Nacca ◽  
Karlo J. Lizarraga
Keyword(s):  
Eye Movements ◽  
High Frequency ◽  
Horizontal Plane ◽  
First Generation ◽  
Over The Counter ◽  
Eyelid Closure ◽  
Burst Neurons ◽  
Ocular Flutter ◽  
Common Causes ◽  
Low Amplitude

Ocular flutter consists of bursts of high-frequency, low-amplitude, conjugate saccadic oscillations without normal intersaccadic interval and confined to the horizontal plane. Ocular flutter can be present during sleep, eyelid closure, attempted fixation, and volitional eye movements. Cerebellar fastigial nuclei disinhibition and/or inhibition of pontine omnipause cells disturb the excitatory/inhibitory balance of brainstem saccadic burst neurons, ultimately leading to saccadic oscillations including ocular flutter.1 The most common causes of ocular flutter in adults are paraneoplastic and parainfectious. Toxic metabolic etiologies are rare and include medications such as phenytoin and venlafaxine. Cerebellar and brainstem lesions have been reported, but the etiology remains unknown in approximately half of these patients.1,2 We present a case of ocular flutter in the setting of acute doxylamine intoxication. Doxylamine is a first-generation antihistamine widely available over the counter (OTC) as a sedative sleep aid, often combined with antitussives and decongestants.

Apparent Dissociation Between Saccadic Eye Movements and the Firing Patterns of Premotor Neurons and Motoneurons

1999 ◽  
Vol 82 (5) ◽  
pp. 2808-2811 ◽  
Author(s):  
Leo Ling ◽  
Albert F. Fuchs ◽  
James O. Phillips ◽  
Edward G. Freedman
Keyword(s):  
Eye Movements ◽  
Eye Movement ◽  
High Frequency ◽  
Action Potentials ◽  
Saccadic Eye Movements ◽  
Line Of Sight ◽  
Movement Amplitude ◽  
Burst Neurons ◽  
Premotor Neurons ◽  
Motoneuron Activity

Saccadic eye movements result from high-frequency bursts of activity in ocular motoneurons. This phasic activity originates in premotor burst neurons. When the head is restrained, the number of action potentials in the bursts of burst neurons and motoneurons increases linearly with eye movement amplitude. However, when the head is unrestrained, the number of action potentials now increase as a function of the change in the direction of the line of sight during eye movements of relatively similar amplitudes. These data suggest an apparent uncoupling of premotor neuron and motoneuron activity from the resultant eye movement.

Speckle interferometric sensor to measure low-amplitude high frequency Ocular Microtremor (OMT)

2009 ◽  
Author(s):  
James P. Ryle ◽  
Mohammed Al-Kalbani ◽  
Unnikrishnan Gopinathan ◽  
Gerard Boyle ◽  
Davis Coakley ◽  
...  
Keyword(s):  
High Frequency ◽  
Interferometric Sensor ◽  
Low Amplitude ◽  
Ocular Microtremor

scholarly journals Novel Experimental Study of Fabric Drying Using Direct-Contact Ultrasonic Vibration

2018 ◽  
Vol 11 (2) ◽  
Author(s):  
Viral K. Patel ◽  
Frederick Kyle Reed ◽  
Roger Kisner ◽  
Chang Peng ◽  
Saeed Moghaddam ◽  
...  
Keyword(s):  
High Frequency ◽  
Direct Contact ◽  
First Generation ◽  
Scale Up ◽  
Enthalpy Of Vaporization ◽  
Piezoelectric Transducers ◽  
Scaling Analysis ◽  
Moisture Removal ◽  
Low Efficiency

Abstract Fabric drying is an energy-intensive process, which generally involves blowing hot dry air across tumbling wet fabric to facilitate evaporation and moisture removal. Most of the energy supplied is used to overcome the enthalpy of vaporization for water. Although this process tends to be inefficient, it is fairly simple and forms the basis for the majority of existing clothes dryer technology today. To address the relatively low efficiency, a new method of drying called “direct contact ultrasonic fabric drying” is proposed. The process involves using high-frequency vibration introduced by piezoelectric transducers, which are in contact with wet fabric. The vibration is used to extract water droplets from the fabric mechanically. In this study, a total of 24 individual transducers are used in a module to dry a 142 cm2 sized fabric. The performance characterization of this single module has enabled successful scale-up of the system to a midscale prototype dryer, which can be used to ultrasonically dry clothing-sized fabric (∼750 cm2). The first-generation ultrasonic fabric dryer fabricated uses as little as 17% of the energy needed by traditional evaporation-based drying techniques. In addition to experimental data, this paper presents the results of a kinetic and scaling analysis that provides some important insights into ultrasonic drying.

scholarly journals Electrocardiography Subtraction Method of Detecting Low-Amplitude, High-Frequency Components (L-HFCs) Within the QRS Complex of Patients With Ventricular Tachycardia

2002 ◽  
Vol 66 (7) ◽  
pp. 649-649
Author(s):  
Toshihiko Nanke ◽  
Kiyoshi Nakazawa ◽  
Mariko Arai ◽  
Shounosuke Ryu ◽  
Tsuneharu Sakurai ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
High Frequency ◽  
Qrs Complex ◽  
Subtraction Method ◽  
Frequency Components ◽  
Low Amplitude

scholarly journals Paediatric brought-in-dead at a tertiary health facility in South western Nigeria: Patterns and drivers

2021 ◽  
Vol 48 (2) ◽  
pp. 66-73
Author(s):  
Oladele S. Olatunya ◽  
Adefunke O. Babatola ◽  
Adewuyi T. Adeniyi ◽  
Adebukola B. Ajite ◽  
Isaac O. Oluwayemi ◽  
...  
Keyword(s):  
Health Facility ◽  
Causes Of Death ◽  
Severe Anaemia ◽  
Hospital Treatment ◽  
Cross Sectional ◽  
Over The Counter ◽  
Pediatric Health Care ◽  
Duration Of Illness ◽  
Common Causes ◽  
Southwest Nigeria

Background: ‘Brought- in-dead’ (BID) refers to the demise of an individual before presentation to a health facility. This study assessed the pattern of paediatric BID cases seen at a tertiary health facility in southwest Nigeria. Method: A cross-sectional, descriptive study was done at the Children Emergency Ward (CEW) of the hospital between January 2014 and December 2018. The patterns of BID cases and presumed causes of death were determined using a standardized checklist adapted from the WHO verbal autopsy instrument. Results: Ninety-eight BID cases were seen during the study, constituting 2.5% of total patients seen during the period. The median (IQR) age of cases was 24.0 (8.75 – 63.0) months and 72.4% were under-fives. Most had symptoms related to the haematologic (36.7%), respiratory (24.5%) or digestive (20.4%) systems. Severe anaemia 31(31.6%), gastroenteritis 19 (19.4) and aspiration 17 (17.3%) were the most common causes of death. The median (IQR) duration of illness before presentation was 3.0 (1.0 – 7.0) days but most presented from 4 – 7 days of illness. A significant relationship was found between the duration of illness and whether or not pre-hospital treatment was received (p < 0.0001). Unprescribed drugs purchased over the counter were the most commonly used treatment in 79.1% of cases (p < 0.0001). Conclusion: This study has highlighted the prevalence and pattern of paediatric BID in a tertiary health facility in southwest Nigeria and the factors that were associated with it. More efforts need to be geared towards community sensitization and pediatric health care to prevent factors drivingits menace.

Clinical significance of high-frequency, low-amplitude electrocardiographic signals and QT dispersion in patients operated on for tetralogy of fallot

1995 ◽  
Vol 76 (5) ◽  
pp. 408-411 ◽  
Author(s):  
Luciano Daliento ◽  
Francesca Caneve ◽  
Pietro Turrini ◽  
Gianfranco Buja ◽  
Andrea Nava ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Clinical Significance ◽  
High Frequency ◽  
Qt Dispersion ◽  
Low Amplitude

High Frequency-Low Amplitude Oscillometry: Continuous Unobtrusive Monitoring of Respiratory Function on PAP Machines

2021 ◽  
pp. 1-1
Author(s):  
Hamed Hanafi Alamdari ◽  
Luke Hacquebard ◽  
Stephen Driscoll ◽  
Kamal El-Sankary ◽  
David Roach ◽  
...  
Keyword(s):  
High Frequency ◽  
Respiratory Function ◽  
Low Amplitude

Optokinetic Responses of the Crab, Carcinus to a Single Moving Light

1966 ◽  
Vol 44 (2) ◽  
pp. 263-274
Author(s):  
G. A. HORRIDGE
Keyword(s):  
Eye Movements ◽  
Apparent Motion ◽  
Horizontal Plane ◽  
Continuous Light ◽  
Lower Percentage ◽  
Eye Position ◽  
Complete Darkness ◽  
Intermittent Light ◽  
Optokinetic Responses ◽  
Dark Room

1. A crab in an otherwise dark room will stabilize its eye position by reference to a single small light, so long as the illumination at the eye exceeds about 0.0003 lux. 2. The eye movements follow the movements of the light. 3. Responses to a light moving in a horizontal plane resemble those to a striped drum, but at lower percentage following. 4. Apparent motion is an effective stimulus; with intermittent light the response is reduced. If there is a period of complete darkness after the first light the subsequent movement, when the second light comes on, is slower for longer dark periods. 5. The crab learns, after some repetitions, to discriminate between a continuous light and an intermittent one, as shown by its eventually stabilizing them at different points on its retina.

Vibrational Control of a 2-Link Mechanism

2020 ◽  
Author(s):  
Zakia Ahmed ◽  
Sevak Tahmasian ◽  
Craig A. Woolsey
Keyword(s):  
Translational Control ◽  
High Frequency ◽  
Horizontal Plane ◽  
High Amplitude ◽  
Torsional Stiffness ◽  
Physical Parameters ◽  
Vibrational Control ◽  
Link Mechanism ◽  
Torsional Damping ◽  
Fixed Input

Abstract This paper describes vibrational control and stability of a planar, horizontal 2-link mechanism using translational control of the base pivot. The system is a 3-DOF two-link mechanism that is subject to torsional damping, torsional stiffness, and is moving on a horizontal plane. The goal is to drive the averaged dynamics of the system to a desired configuration using a high-frequency, high-amplitude force applied at the base pivot. The desired configuration is achieved by applying an amplitude and angle of the input determined using the averaged dynamics of the system. We find the range of stable configurations that can be achieved by the system by changing the amplitude of the oscillations for a fixed input angle and oscillation frequency. The effects of varying the physical parameters on the achievable stable configurations are studied. Stability analysis of the system is performed using two methods: the averaged dynamics and averaged potential.

scholarly journals What about “Pharming”? Issues Regarding the Misuse of Prescription and Over-the-Counter Drugs

2020 ◽  
Vol 10 (10) ◽  
pp. 736
Author(s):  
Stefania Chiappini ◽  
Fabrizio Schifano
Keyword(s):  
Prescription Drugs ◽  
First Generation ◽  
Drug Misuse ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Over The Counter ◽  
Emerging Trends ◽  
Second Generation Antipsychotics ◽  
Other Substances

Recently, a range of prescription and over-the-counter (OTC) drugs have emerged as being used recreationally, either on their own or in combination with other substances, both licit and illicit, including new psychoactive substances (NPS). Among them, the misuse of prescription drugs involves not only traditionally recorded substances, such as benzodiazepines and opioid pain relievers, but also gabapentinoids (e.g., pregabalin and gabapentin); some antidepressants, e.g., bupropion and venlafaxine; some second-generation antipsychotics, e.g., quetiapine and olanzapine. Moreover, the use of some OTC for recreational purposes appears on the increase, especially in vulnerable categories such as young people/youths, including the use of high dosages of the antidiarrheal loperamide; first-generation antihistamines, e.g., promethazine, cyclizine, and diphenhydramine; cough and cold preparations containing dextromethorphan and/or codeine. In this context, the role of the Internet has rapidly increased, playing a significant role both in the diffusion of emerging trends of drug misuse among users and experimenters, and the marketing, sale, and distribution of drugs through online pharmacies. This phenomenon within the context of a rapidly modifying drug scenario is a globally recognized health problem, determining severe adverse consequences, including fatalities, and represents a challenge for clinicians in general, psychiatrists, public health, and drug-control policies.

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