scholarly journals Perception and Use of Compensation Strategies for Gait Impairment by Persons With Parkinson Disease

Neurology ◽  
2021 ◽  
Vol 97 (14) ◽  
pp. e1404-e1412 ◽  
Author(s):  
Anouk Tosserams ◽  
Lisanne Wit ◽  
Ingrid H.W.M. Sturkenboom ◽  
Maarten J. Nijkrake ◽  
Bastiaan R. Bloem ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Patient Characteristics ◽  
Full Spectrum ◽  
Gait Impairment ◽  
Clinical Observations ◽  
Actual Use ◽  
Personalized Approach ◽  
The Individual ◽  
Gait Impairments

Background and ObjectivesGait impairments are common and disabling in Parkinson disease (PD). Applying compensation strategies helps to overcome these gait deficits. Clinical observations suggest that the efficacy of different compensation strategies varies depending on both individual patient characteristics and the context in which the strategies are applied. This has never been investigated systematically, hampering the ability of clinicians to provide a more personalized approach to gait rehabilitation. We had 3 aims: (1) to evaluate patients' awareness and actual use of compensation categories for gait impairments in PD, (2) to investigate the patient-rated efficacy of the various compensation strategies and whether this efficacy depends on the context in which the strategies are applied, and (3) to explore differences in the efficacy between subgroups based on sex, age, disease duration, freezing status, and ability to perform a dual task.MethodsA survey was conducted among 4,324 adults with PD and self-reported disabling gait impairments.ResultsThe main findings are as follows: (1) compensation strategies for gait impairments are commonly used by persons with PD, but their awareness of the full spectrum of available strategies is limited; (2) the patient-rated efficacy of compensation strategies is high but varies depending on the context in which they are applied; and (3) compensation strategies are useful for all types of patients with PD, but the efficacy of the different strategies varies per person.DiscussionThe choice of compensation strategies for gait impairment in PD should be tailored to the individual patient and to the context in which the strategy needs to be applied.Classification of EvidenceThis data provides Class IV evidence that compensation strategies are an effective treatment for gait impairment in patients with PD.

Phonetic iconicity in the evaluative morphology of a sample of Indo-European, Niger-Congo and Austronesian languages

2010 ◽  
Vol 3 (2) ◽  
pp. 156-180 ◽  
Author(s):  
Renáta Gregová ◽  
Lívia Körtvélyessy ◽  
Július Zimmermann
Keyword(s):  
Three Dimensional ◽  
Sound Symbolism ◽  
Three Dimensional Model ◽  
Austronesian Languages ◽  
Place Of Articulation ◽  
European Languages ◽  
Phonetic Symbolism ◽  
The Individual ◽  
Core Vocabulary

Universals Archive (Universal #1926) indicates a universal tendency for sound symbolism in reference to the expression of diminutives and augmentatives. The research ( Štekauer et al. 2009 ) carried out on European languages has not proved the tendency at all. Therefore, our research was extended to cover three language families – Indo-European, Niger-Congo and Austronesian. A three-step analysis examining different aspects of phonetic symbolism was carried out on a core vocabulary of 35 lexical items. A research sample was selected out of 60 languages. The evaluative markers were analyzed according to both phonetic classification of vowels and consonants and Ultan's and Niewenhuis' conclusions on the dominance of palatal and post-alveolar consonants in diminutive markers. Finally, the data obtained in our sample languages was evaluated by means of a three-dimensional model illustrating the place of articulation of the individual segments.

scholarly journals Structural variant detection in cancer genomes: computational challenges and perspectives for precision oncology

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Ianthe A. E. M. van Belzen ◽  
Alexander Schönhuth ◽  
Patrick Kemmeren ◽  
Jayne Y. Hehir-Kwa
Keyword(s):  
Intratumor Heterogeneity ◽  
Precision Oncology ◽  
Single Nucleotide Variants ◽  
Full Spectrum ◽  
Single Nucleotide ◽  
Sequencing Technologies ◽  
Cancer Genomes ◽  
Genomic Aberrations

AbstractCancer is generally characterized by acquired genomic aberrations in a broad spectrum of types and sizes, ranging from single nucleotide variants to structural variants (SVs). At least 30% of cancers have a known pathogenic SV used in diagnosis or treatment stratification. However, research into the role of SVs in cancer has been limited due to difficulties in detection. Biological and computational challenges confound SV detection in cancer samples, including intratumor heterogeneity, polyploidy, and distinguishing tumor-specific SVs from germline and somatic variants present in healthy cells. Classification of tumor-specific SVs is challenging due to inconsistencies in detected breakpoints, derived variant types and biological complexity of some rearrangements. Full-spectrum SV detection with high recall and precision requires integration of multiple algorithms and sequencing technologies to rescue variants that are difficult to resolve through individual methods. Here, we explore current strategies for integrating SV callsets and to enable the use of tumor-specific SVs in precision oncology.

Classification of Parkinson disease using binary Rao optimization algorithms

2021 ◽  
Author(s):  
Suvita Rani Sharma ◽  
Birmohan Singh ◽  
Manpreet Kaur
Keyword(s):  
Parkinson Disease ◽  
Optimization Algorithms

Off-line classification of Polish vowel spectra using artificial neural networks

2004 ◽  
Vol 34 (1) ◽  
pp. 37-52
Author(s):  
Wiktor Jassem ◽  
Waldemar Grygiel
Keyword(s):  
Neural Networks ◽  
Numerical Data ◽  
Word List ◽  
Original Data ◽  
Data Matrix ◽  
Probabilistic Neural Networks ◽  
Independent Variable ◽  
The Individual ◽  
Vowel Phoneme

The mid-frequencies and bandwidths of formants 1–5 were measured at targets, at plus 0.01 s and at minus 0.01 s off the targets of vowels in a 100-word list read by five male and five female speakers, for a total of 3390 10-variable spectrum specifications. Each of the six Polish vowel phonemes was represented approximately the same number of times. The 3390* 10 original-data matrix was processed by probabilistic neural networks to produce a classification of the spectra with respect to (a) vowel phoneme, (b) identity of the speaker, and (c) speaker gender. For (a) and (b), networks with added input information from another independent variable were also used, as well as matrices of the numerical data appropriately normalized. Mean scores for classification with respect to phonemes in a multi-speaker design in the testing sets were around 95%, and mean speaker-dependent scores for the phonemes varied between 86% and 100%, with two speakers scoring 100% correct. The individual voices were identified between 95% and 96% of the time, and classifications of the spectra for speaker gender were practically 100% correct.

Individual and Community: The Changing Role of Megaliths in the Orcadian Neolithic

1985 ◽  
Vol 51 (1) ◽  
pp. 59-74 ◽  
Author(s):  
Niall Sharples
Keyword(s):  
The Other ◽  
Significant Problem ◽  
Neolithic Period ◽  
Size Type ◽  
The Individual ◽  
Changing Role

This paper is an exploration of the chronological development of a series of elaborate and architecturally distinctive chambered tombs on the Islands of Orkney. It begins with a short critique of the present views of the Orcadian Neolithic and highlights a failure to understand chronological developments as the most significant problem. Thus after a brief classification of the monuments there is a detailed discussion of the chronological evidence which consciously avoids typological assumptions. This is followed by an examination of the various uses the tombs were put to and involves an assessment of the location and architectural visibility of the monuments and the remains found in the chamber. When combined with the chronological evidence a series of changes in monument size, type, location and use can be hypothesized for the neolithic period. This culminates in a shift away from burial monuments to physically defined spaces, presumably used for ceremonial purposes. These changes can be interpreted as deliberate manipulation by groups within that society to change the ideological concepts which defined the role of the individual in relation to the other members of the society.

Application of Problem Situations for the Development of Learning Skills in the Study of Natural Sciences

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Margarita Slavova ◽  
Angel Slavchev
Keyword(s):  
Health Education ◽  
Personal Development ◽  
Logical Structure ◽  
Natural Sciences ◽  
Final Decision ◽  
Problem Situation ◽  
Learning Skills ◽  
Problem Situations ◽  
The Individual

The problem situation is one of the ways to form general learning skills in the study of natural sciences. It provides an opportunity to apply the individual approach, choosing a path for making a final decision and full personal development of the student. This article reviews the nature of the problem situation and learning skills, presents a classification of species and offers an example of use in teaching biology and health education - 7th grade to develop the skill of comparison. The article aims to guide teachers in the logical structure for creating a problem situation and the requirements for the content of individual elements. An option for linking it with a specific educational content is also shown.

Approaches To The Concept Of Social Mobility

2021 ◽  
Vol 03 (02) ◽  
pp. 19-26
Author(s):  
Isakov S.D. ◽  
Keyword(s):  
Social Status ◽  
Social Mobility ◽  
Social Role ◽  
The Individual ◽  
Sociological Interpretation

The article discusses the sociological interpretation of the concept of social mobility, its generality with the concept of stratification and features of individuality. The emergence of social mobility with the change of social status and social role of the individual is also emphasized. The article also briefly discusses the classification of social mobility.

Sign in / Sign up

Export Citation Format

Share Document