scholarly journals Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease

Neurology ◽  
2010 ◽  
Vol 74 (6) ◽  
pp. 480-486 ◽  
Author(s):  
F. Zou ◽  
M. M. Carrasquillo ◽  
V. S. Pankratz ◽  
O. Belbin ◽  
K. Morgan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer Disease ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Expression Levels ◽  
Genome Wide ◽  
Gene Expression Levels

P1-229: Genome-Wide Association Study of Brain Gene Expression Levels (eGWAS)

2011 ◽  
Vol 7 ◽  
pp. S184-S184
Author(s):  
Nilufer Ertekin-Taner ◽  
Fanggeng Zou ◽  
High Chai ◽  
Curtis Younkin ◽  
Julia Crook ◽  
...  
Keyword(s):  
Gene Expression ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Expression Levels ◽  
Brain Gene Expression ◽  
Genome Wide ◽  
Gene Expression Levels

Genome-wide Association of Haplotype Markers to Gene Expression Levels

2003 ◽  
Vol 68 (0) ◽  
pp. 89-108
Author(s):  
A. WINDEMUTH ◽  
M. KUMAR ◽  
K. NANDABALAN ◽  
B. KOSHY ◽  
C. XU ◽  
...  
Keyword(s):  
Gene Expression ◽  
Genome Wide Association ◽  
Expression Levels ◽  
Genome Wide ◽  
Gene Expression Levels

scholarly journals Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data

2018 ◽  
Author(s):  
Kristin M. Mignogna ◽  
Silviu A. Bacanu ◽  
Brien P. Riley ◽  
Aaron R. Wolen ◽  
Michael F. Miles
Keyword(s):  
Gene Expression ◽  
Alcohol Dependence ◽  
Mouse Brain ◽  
Gene Networks ◽  
Association Studies ◽  
Complex Trait ◽  
Genome Wide Association ◽  
Model Organisms ◽  
Genome Wide Association Studies ◽  
Genome Wide

AbstractGenome-wide association studies on alcohol dependence, by themselves, have yet to account for the estimated heritability of the disorder and provide incomplete mechanistic understanding of this complex trait. Integrating brain ethanol-responsive gene expression networks from model organisms with human genetic data on alcohol dependence could aid in identifying dependence-associated genes and functional networks in which they are involved. This study used a modification of the Edge-Weighted Dense Module Searching for genome-wide association studies (EW-dmGWAS) approach to co-analyze whole-genome gene expression data from ethanol-exposed mouse brain tissue, human protein-protein interaction databases and alcohol dependence-related genome-wide association studies. Results revealed novel ethanol-regulated and alcohol dependence-associated gene networks in prefrontal cortex, nucleus accumbens, and ventral tegmental area. Three of these networks were overrepresented with genome-wide association signals from an independent dataset. These networks were significantly overrepresented for gene ontology categories involving several mechanisms, including actin filament-based activity, transcript regulation, Wnt and Syndecan-mediated signaling, and ubiquitination. Together, these studies provide novel insight for brain mechanisms contributing to alcohol dependence.

scholarly journals The Effect of Single Nucleotide Polymorphisms from Genome Wide Association Studies in Multiple Sclerosis on Gene Expression

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10142 ◽  
Author(s):  
Adam E. Handel ◽  
Lahiru Handunnetthi ◽  
Antonio J. Berlanga ◽  
Corey T. Watson ◽  
Julia M. Morahan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphisms ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Genome Wide
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