Alzheimer's disease: Interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity, and age of onset

Neurology ◽  
1996 ◽  
Vol 46 (6) ◽  
pp. 1575-1579 ◽  
Author(s):  
R. Duara ◽  
W. W. Barker ◽  
R. Lopez-Alberola ◽  
D. A. Loewenstein ◽  
L. B. Grau ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Apolipoprotein E ◽  
Age Of Onset ◽  
Gender Education ◽  
History Of ◽  
Apolipoprotein E Genotype

The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease

2010 ◽  
Vol 25 (5) ◽  
pp. 511-518 ◽  
Author(s):  
Dylan G. Harwood ◽  
Ari Kalechstein ◽  
Warren W. Barker ◽  
Silvia Strauman ◽  
Peter St. George-Hyslop ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Age Of Onset ◽  
Tobacco Consumption ◽  
Apolipoprotein E Genotype

Alzheimer’s Disease and History of Blood Transfusion by Apolipoprotein-E Genotype

1997 ◽  
Vol 16 (2) ◽  
pp. 86-93 ◽  
Author(s):  
E.S. O'Meara ◽  
W.A. Kukull ◽  
G.D. Schellenberg ◽  
J.D. Bowen ◽  
W.C. McCormick ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Transfusion ◽  
Apolipoprotein E ◽  
History Of ◽  
Apolipoprotein E Genotype

scholarly journals Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Joshua S Talboom ◽  
Asta Håberg ◽  
Matthew D De Both ◽  
Marcus A Naymik ◽  
Isabelle Schrauwen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Family History ◽  
Apolipoprotein E ◽  
Sex Education ◽  
Genetic Factors ◽  
Paired Associates ◽  
History Of ◽  
Ε4 Allele

In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer’s disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18–85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified.

P1-282: Apolipoprotein E genotype in biparietal Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S179-S179
Author(s):  
Jonathan M. Schott ◽  
Basil H. Ridha ◽  
Sebastian J. Crutch ◽  
Elizabeth K. Warrington ◽  
Martin N. Rossor ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype

Apolipoprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent

1999 ◽  
Vol 843 (1-2) ◽  
pp. 87-94 ◽  
Author(s):  
Uwe Beffert ◽  
Jeffrey S Cohn ◽  
Caroline Petit-Turcotte ◽  
Michel Tremblay ◽  
Nicole Aumont ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Frontal Cortex ◽  
Β Amyloid ◽  
Apolipoprotein E Genotype
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