Patches in the livers of chimaeric mice

Development ◽  
1976 ◽  
Vol 36 (1) ◽  
pp. 151-161
Author(s):  
J. D. West
Keyword(s):  
Clonal Analysis ◽  
Cell Populations ◽  
Adult Liver ◽  
One Dimensional ◽  
Glucuronidase Activity

Sections of adult chimaeric livers have been histochemically stained for β-glucuronidase activity and patches of two cell populations visualized. A one-dimensional clonal analysis has been used to estimate the number of coherent clones in the adult liver. The data are consistent with a total of 9–22 million regular, coherent clones, comprising 10–34 nuclei, or a smaller number of irregular, branched coherent clones. Both of these alternatives suggest considerable cell mixing during liver morphogenesis.

scholarly journals Functional and biochemical studies of multinucleated giant cells derived from the culture of human monocytes.

1984 ◽  
Vol 159 (4) ◽  
pp. 1289-1294 ◽  
Author(s):  
L Schlesinger ◽  
R A Musson ◽  
R B Johnston
Keyword(s):  
Host Defense ◽  
Specific Activity ◽  
Cell Types ◽  
Giant Cells ◽  
Cell Populations ◽  
Human Monocytes ◽  
Multinucleated Giant Cells ◽  
Glucuronidase Activity ◽  
Biochemical Studies ◽  
Metabolic Activities

We compared phagocytic and metabolic activities of multinucleated giant cells (MGC) and macrophages derived from human monocytes after 9-14 d in culture. Phagocytosis of sheep erythrocytes (E) coated with IgG, of E coated with IgM and complement, and of Candida albicans was comparable in MGC and macrophages. The same percentage of ingested fungi was killed by MGC (24 +/- 4%) and macrophages (21 +/- 5%). Approximately 70% of MGC and macrophages exhibited superoxide-dependent reduction of nitroblue tetrazolium during stimulation. Ia antigen was present on approximately 75% of both cell types. Analysis of cell populations separated by nuclear fluorescence indicated that beta-glucosaminidase, acid phosphatase, and beta-glucuronidase activity per cell was higher in MGC, but specific activity of these enzymes was greater in macrophages. These results suggest that MGC have the capacity to function like macrophages in host defense against infection.

scholarly journals Clonal analysis of childhood acute lymphoblastic leukemia with "cytogenetically independent" cell populations.

1989 ◽  
Vol 83 (6) ◽  
pp. 1971-1977 ◽  
Author(s):  
C H Pui ◽  
W H Raskind ◽  
G R Kitchingman ◽  
S C Raimondi ◽  
F G Behm ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Clonal Analysis ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cell Populations

scholarly journals Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates

Hepatology ◽  
2010 ◽  
Vol 52 (4) ◽  
pp. 1443-1454 ◽  
Author(s):  
Yunfang Wang ◽  
Hsin-Lei Yao ◽  
Cai-Bin Cui ◽  
Eliane Wauthier ◽  
Claire Barbier ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Cell ◽  
Cell Populations ◽  
Hepatic Stem Cells ◽  
Adult Liver

298 ISOLATION AND CULTIVATION OF PURE HUMAN ADULT LIVER STEM CELL POPULATIONS FROM PATIENT LIVER RESECTATES

2013 ◽  
Vol 58 ◽  
pp. S125-S126
Author(s):  
N. Fekete-Drimusz ◽  
I. Meder ◽  
U. Rüdrich ◽  
K. Preis ◽  
R. Gutierrez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Populations ◽  
Adult Liver ◽  
Human Adult ◽  
Stem Cell Populations

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

Science ◽  
2021 ◽  
Vol 371 (6532) ◽  
pp. eabc4346 ◽  
Author(s):  
Lingjuan He ◽  
Wenjuan Pu ◽  
Xiuxiu Liu ◽  
Zhenqian Zhang ◽  
Maoying Han ◽  
...  
Keyword(s):  
Mouse Liver ◽  
Genetic System ◽  
Clonal Analysis ◽  
Lineage Tracing ◽  
Hepatocyte Proliferation ◽  
Cell Populations ◽  
Injury Repair ◽  
Multiple Organs ◽  
Entire Cell ◽  
Cellular Compartments

Organ homeostasis is orchestrated by time- and spatially restricted cell proliferation. Studies identifying cells with superior proliferative capacities often rely on the lineage tracing of a subset of cell populations, which introduces a potential selective bias. In this work, we developed a genetic system [proliferation tracer (ProTracer)] by incorporating dual recombinases to seamlessly record the proliferation events of entire cell populations over time in multiple organs. In the mouse liver, ProTracer revealed more hepatocyte proliferation in distinct zones during liver homeostasis, injury repair, and regrowth. Clonal analysis showed that most of the hepatocytes labeled by ProTracer had undergone cell division. By genetically recording proliferation events of entire cell populations, ProTracer enables the unbiased detection of specific cellular compartments with enhanced regenerative capacities.

T cell nature of some lymphokine-activated killer (LAK) cells. Frequency analysis of LAK precursors within human T cell populations and clonal analysis of LAK effector cells

1986 ◽  
Vol 16 (12) ◽  
pp. 1623-1625 ◽  
Author(s):  
Lorenzo Moretta ◽  
Daniela Pende ◽  
Raffaella Cozzani ◽  
Annalisa Merli ◽  
Marcello Bagnasco ◽  
...  
Keyword(s):  
T Cell ◽  
Frequency Analysis ◽  
Clonal Analysis ◽  
Lak Cells ◽  
Cell Populations ◽  
Effector Cells ◽  
Human T Cell

A one-dimensional self-gravitating stellar gas

1966 ◽  
Vol 25 ◽  
pp. 46-48 ◽  
Author(s):  
M. Lecar
Keyword(s):  
Gravitational Field ◽  
Phase Space ◽  
Motion Picture ◽  
Space Distribution ◽  
Two Dimensional ◽  
One Dimensional ◽  
Phase Space Distribution ◽  
Dimensional Phase Space ◽  
The Mean

“Dynamical mixing”, i.e. relaxation of a stellar phase space distribution through interaction with the mean gravitational field, is numerically investigated for a one-dimensional self-gravitating stellar gas. Qualitative results are presented in the form of a motion picture of the flow of phase points (representing homogeneous slabs of stars) in two-dimensional phase space.

Electron microscopy of endocardial cell populations

1978 ◽  
Vol 36 (2) ◽  
pp. 486-487
Author(s):  
T. G. Sarphie ◽  
C. R. Comer ◽  
D. J. Allen
Keyword(s):  
Electron Microscopy ◽  
Plasma Membrane ◽  
Cellular Transformation ◽  
Cell Populations ◽  
Cell Surfaces ◽  
Kb Cells ◽  
Dna Viruses ◽  
Cell Cycles ◽  
Ultrastructural Studies ◽  
Endocardial Cell

Previous ultrastructural studies have characterized surface morphology during norma cell cycles in an attempt to associate specific changes with specific metabolic processes occurring within the cell. It is now known that during the synthetic ("S") stage of the cycle, when DNA and other nuclear components are synthesized, a cel undergoes a doubling in volume that is accompanied by an increase in surface area whereby its plasma membrane is elaborated into a variety of processes originally referred to as microvilli. In addition, changes in the normal distribution of glycoproteins and polysaccharides derived from cell surfaces have been reported as depreciating after cellular transformation by RNA or DNA viruses and have been associated with the state of growth, irregardless of the rate of proliferation. More specifically, examination of the surface carbohydrate content of synchronous KB cells were shown to be markedly reduced as the cell population approached division Comparison of hamster kidney fibroblasts inhibited by vinblastin sulfate while in metaphase with those not in metaphase demonstrated an appreciable decrease in surface carbohydrate in the former.

Electron-Mirror Microscopic Aspects of Ferroelectric Domains of BaTiO3 And Ca2Sr (C2H5CO2)6

1970 ◽  
Vol 28 ◽  
pp. 478-479
Author(s):  
Teruo Someya ◽  
Jinzo Kobayashi
Keyword(s):  
Surface Layer ◽  
Electric Fields ◽  
Quantitative Study ◽  
Recent Progress ◽  
Ferroelectric Domain ◽  
Resolving Power ◽  
Surface Pattern ◽  
Crystal Surfaces ◽  
One Dimensional ◽  
Ferroelectric Domains

Recent progress in the electron-mirror microscopy (EMM), e.g., an improvement of its resolving power together with an increase of the magnification makes it useful for investigating the ferroelectric domain physics. English has recently observed the domain texture in the surface layer of BaTiO3. The present authors ) have developed a theory by which one can evaluate small one-dimensional electric fields and/or topographic step heights in the crystal surfaces from their EMM pictures. This theory was applied to a quantitative study of the surface pattern of BaTiO3).

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