scholarly journals Androgens modulate the inflammatory response during acute wound healing

2006 ◽  
Vol 119 (4) ◽  
pp. 722-732 ◽  
Author(s):  
S. C. Gilliver
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Acute Wound

scholarly journals Naoxintong accelerates diabetic wound healing by attenuating inflammatory response

2021 ◽  
Vol 59 (1) ◽  
pp. 252-261
Author(s):  
Leyu Fang ◽  
Lu Chen ◽  
Min Song ◽  
Juan He ◽  
Lusha Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals 223 Murine cutaneous microbiota composition is largely mouse strain determined with microbiota changes during acute wound healing showing mouse strain specific responses

2021 ◽  
Vol 141 (5) ◽  
pp. S40
Author(s):  
J. Galbraith ◽  
J. Legrand ◽  
N. Muller ◽  
K. Togher ◽  
N. Matigian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mouse Strain ◽  
Microbiota Composition ◽  
Acute Wound

Monitoring of Acute Wound Healing

2008 ◽  
Author(s):  
Elisabeth S. Papazoglou ◽  
Michael S. Weingarten ◽  
Leonid Zubkov ◽  
Michael Neidrauer ◽  
Linda Zhu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Acute Wound

Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

2021 ◽  
pp. 153473462110290
Author(s):  
Nazira Fatima ◽  
Muhammad Saleem
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Sodium Nitroprusside ◽  
Bone Marrow Cells ◽  
Healing Process ◽  
Wound Healing Process ◽  
Inflammatory Infiltration ◽  
Acute Wound ◽  
High Concentrations ◽  
Marrow Cells

The development of wound healing impairment mainly represents challenging clinical problems. The less and high concentrations of nitric oxide can influence angiogenesis, remodeling, and proliferation of skin cells. Delayed acute wounds generally have failed to progress via the normal stages of healing. Such wounds usually enter a state of pathological inflammation due to a postponed, incomplete, and uncoordinated healing process. This study aimed to investigate the effect of normal bone marrow cells (BMCs) and preconditioning of BMCs with minimum concentrations of sodium nitroprusside (NaNP) solution for acute wound healing. For acute wound healing, full-thickness dorsal wounds were created on rabbits. The acute wound of rabbits was treated with BMCs and preactivated BMCs with NaNP. Histological results showed that BMCs preactivated with NaNP could improve collagen deposition, enhanced reepithelization, and decreased inflammatory infiltration. Overall, BMCs treated with NaNP can help to improve acute wound healing in rabbits. The result strongly confirmed the beneficial effect in augmenting the wound healing process. The combination of BMCs with NaNP was safe and convenient for acute wound healing.

scholarly journals Effects of Hyperbaric Oxygen on Inflammatory Response to Wound and Trauma: Possible Mechanism of Action

2006 ◽  
Vol 6 ◽  
pp. 425-441 ◽  
Author(s):  
Noori S. Al-Waili ◽  
Glenn J. Butler
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Inflammatory Response ◽  
Hyperbaric Oxygen ◽  
Mechanism Of Action ◽  
Chronic Wounds ◽  
Carbon Monoxide Poisoning ◽  
Clinical Applications ◽  
No Production ◽  
Mediators Of Inflammation

There is growing interest in expanding the clinical applications for HBO2(hyperbaric oxygen therapy) into new medical and surgical fields. The pathophysiology of response towards wounds, infection, trauma, or surgery involves various chemical mediators that include cytokines, prostaglandins (PGs), and nitric oxide (NO). The beneficial role played by HBO2in wound healing, carbon monoxide poisoning, decompression sickness, and other indications is well documented. However, the exact mechanism of action is still poorly understood. This review addresses the effects of HBO2on PGs, NO, and cytokines involved in wound pathophysiology and inflammation in particular. The results of this review indicate that HBO2has important effects on the biology of cytokines and other mediators of inflammation. HBO2causes cytokine down-regulation and growth factor up-regulation. HBO2transiently suppresses stimulus-induced proinflammatory cytokine production and affects the liberation of TNFα (tumor necrosis factor alpha) and endothelins. VEGF (vascular endothelial growth factor) levels are significantly increased with HBO2, whereas the value of PGE2 and COX-2 mRNA are markedly reduced. The effect of HBO2on NO production is not well established and more studies are required. In conclusion, cytokines, PGs, and NO may play a major role in the mechanism of action of HBO2 and further research could pave the way for new clinical applications for HBO2to be established. It could be proposed that chronic wounds persist due to an uncontrolled pathological inflammatory response in the wound bed and that HBO2enhances wound healing by damping pathological inflammation (anti-inflammatory effects); this hypothetical proposal remains to be substantiated with experimental results.

scholarly journals Investigating the Wound Healing Potential of the Polyherbal Gels Prepared with Ficus Extract

2018 ◽  
Vol 8 (2) ◽  
pp. 13-16
Author(s):  
Mahender K ◽  
Ravi D ◽  
Chaitanya Kumar K ◽  
Mothilal K
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Human Body ◽  
Healing Process ◽  
The Body ◽  
Wound Healing Process ◽  
Aqueous Extracts ◽  
Standard Drug ◽  
Carbopol Gel ◽  
Ficus Benghalensis

Wounds are nothing but any damage to the tissue or skin that can be healed. The wound healing process is usually built in the human body to self heal many wounds. When there is an injury in the body, there is an inflammatory response that is generated in the body, and the cells begin to raise the collagen levels in the skin which enables to increase the healing process. Ficus species of plants are famous for their potency to treat diseases in various Indian systems of medicine and the tree is commonly called as a banyan. Especially the plant in the species benghalensis is used to treat rheumatism, wounds and other skin related problems like an ulcer. The herbal gels were prepared using the incorporation of the aqueous extracts of the plant Ficus benghalensis into carbopol gel. They were investigated for the wound healing potential compared to the betadine drug standard. The gels at a concentration 200mg/g of the gel showed better activity compared to the gel at 100mg/g and the standard drug, betadine.

scholarly journals A 3D In Vitro Model for Burn Wounds: Monitoring of Regeneration on the Epidermal Level

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1153
Author(s):  
Verena Schneider ◽  
Daniel Kruse ◽  
Ives Bernardelli de Mattos ◽  
Saskia Zöphel ◽  
Kendra-Kathrin Tiltmann ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Healing Process ◽  
Three Dimensional ◽  
Source Model ◽  
Burn Wound ◽  
Thermal Burn ◽  
Burn Wounds

Burns affect millions every year and a model to mimic the pathophysiology of such injuries in detail is required to better understand regeneration. The current gold standard for studying burn wounds are animal models, which are under criticism due to ethical considerations and a limited predictiveness. Here, we present a three-dimensional burn model, based on an open-source model, to monitor wound healing on the epidermal level. Skin equivalents were burned, using a preheated metal cylinder. The healing process was monitored regarding histomorphology, metabolic changes, inflammatory response and reepithelialization for 14 days. During this time, the wound size decreased from 25% to 5% of the model area and the inflammatory response (IL-1β, IL-6 and IL-8) showed a comparable course to wounding and healing in vivo. Additionally, the topical application of 5% dexpanthenol enhanced tissue morphology and the number of proliferative keratinocytes in the newly formed epidermis, but did not influence the overall reepithelialization rate. In summary, the model showed a comparable healing process to in vivo, and thus, offers the opportunity to better understand the physiology of thermal burn wound healing on the keratinocyte level.

scholarly journals The Effect of 17β-Estradiol Administration on Cutaneous Wound Healing in 24-Week Ovariectomized Female Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Kanae Mukai ◽  
Yukari Nakajima ◽  
Tamae Urai ◽  
Emi Komatsu ◽  
Kana Takata ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Estrogen Replacement ◽  
Wound Area ◽  
Cutaneous Wound ◽  
Female Mice ◽  
Exogenous Estrogen ◽  
17Β Estradiol

Estrogen replacement promotes cutaneous wound healing in 8–10-week young ovariectomized female mice. However, research using aged ovariectomized female mice has not been reported, to the best of our knowledge. Therefore, we investigated the effect of 17β-estradiol on cutaneous wound healing using 24-week middle-aged ovariectomized female mice. Twenty-week-old female mice were divided into three groups: medication with 17β-estradiol after ovariectomy (OVX + 17β-estradiol), ovariectomy (OVX), and sham (SHAM). After 4 weeks, the mice received two full-thickness wounds. Then, the OVX + 17β-estradiol group was administered 17β-estradiol at 0.01 g/day until healing. The ratio of wound area in the OVX + 17β-estradiol group was significantly decreased compared with that in the OVX group. The numbers of neutrophils and macrophages in the OVX + 17β-estradiol group were significantly smaller than those in the OVX group. In addition, the ratio of myofibroblasts in the OVX + 17β-estradiol group was significantly higher than that in the OVX group. These data suggested that exogenous continuous 17β-estradiol administration promotes cutaneous wound healing in 24-week OVX female mice by reducing wound area, shortening inflammatory response, and promoting wound contraction. However, it is unclear whether the effect of exogenous estrogen on wound healing outweighs the delay of wound healing due to advanced age.

Management of Acute Wounds

2019 ◽  
Author(s):  
Lee D. Faucher ◽  
Angela L. Gibson
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Wound Closure ◽  
Wound Care ◽  
Connective Tissue Diseases ◽  
Skin Grafting ◽  
Adjunctive Treatment ◽  
Local Trauma ◽  
Life Threatening ◽  
Acute Wound

Acute wounds are the result of local trauma and may be associated with severe life-threatening injuries. All patients with acute wounds should be assessed for comorbidities such as malnutrition, diabetes, peripheral vascular disease, neuropathy, obesity, immune deficiency, autoimmune disorders, connective tissue diseases, coagulopathy, hepatic dysfunction, malignancy, smoking practices, medication use that could interfere with healing, and allergies. The authors address the key considerations in management of the acute wound, including anesthesia, location of wound repair (e.g. operating room or emergency department), hemostasis, irrigation, débridement, closure materials, timing and methods of closure, adjunctive treatment (e.g. tetanus and rabies prophylaxis, antibiotics, and nutritional supplementation), appropriate closure methods for specific wound types, dressings, postoperative wound care, and potential disturbances of wound healing.  This review contains 11 figures, 31 tables, and 92 references. Keywords: wound, wound infection, burns, suture, staple, wound closure, wound healing, dehiscence, skin grafting

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