The erythroid cells of anaemic Xenopus laevis. I. Studies on cellular morphology and protein and nucleic acid synthesis during differentiation

1975 ◽  
Vol 19 (3) ◽  
pp. 509-520
Author(s):  
N. Thomas ◽  
N. Maclean
Keyword(s):  
Nucleic Acid ◽  
Xenopus Laevis ◽  
Acid Synthesis ◽  
Cellular Morphology ◽  
Nucleic Acid Synthesis ◽  
Erythroid Cells ◽  
Complete Destruction ◽  
Large Numbers

Phenylhydrazine has been used to induce anaemia in Xenopus laevis. The dosage used causes the complete destruction of all mature erythrocytes within twelve days. The anaemia results in the initiation of a wave of erythropoiesis and large numbers of immature erythroid cells are released into the circulation. The morphological and biosynthetic changes which these cells undergo as they differentiate in circulation are described. The origin of the circulating erythroid cells is also discussed.

The relative rates of synthesis of DNA, sRNA and rRNA in the endodermal region and other parts of Xenopus laevis embryos

Development ◽  
1968 ◽  
Vol 19 (3) ◽  
pp. 363-385
Author(s):  
H. R. Woodland ◽  
J. B. Gurdon
Keyword(s):  
Nucleic Acid ◽  
Xenopus Laevis ◽  
Nucleic Acids ◽  
Cell Types ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis ◽  
Direct Measure ◽  
Cell Type ◽  
Different Cell Types ◽  
Xenopus Laevis Embryos

The onset and rates of synthesis of the major classes of nucleic acids have been extensively studied during the development of whole frog embryos (reviews by Brown, 1965; Gurdon, 1967a). Such information is of interest because nucleic acids are the immediate products of genes, and their rates of synthesis therefore provide a direct measure of changes in gene activity. To date nucleic acid synthesis in parts of frog embryos has been analysed mainly by methods which do not distinguish different classes of RNA (e.g. Bachvarova & Davidson, 1966; Flickinger, Miyagi, Moser & Rollins, 1967). Since embryos consist of many different cell types, it is important to know to what extent the pattern of nucleic acid synthesis observed in the whole embryo is true for its individual regions, and in particular for one differentiating cell type.

scholarly journals Role of Folic Acid and Energy Intake in Nucleic Acid Synthesis

1959 ◽  
Vol 234 (3) ◽  
pp. 625-627
Author(s):  
Ranjan Mehta ◽  
David A. Vaughan ◽  
Shreepad R. Wagle ◽  
Kendall D. Barbee ◽  
S.P. Mistry ◽  
...  
Keyword(s):  
Folic Acid ◽  
Nucleic Acid ◽  
Energy Intake ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis
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