Limited Prognostic Value of KRAS in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

2021 ◽  
Author(s):  
Yoshinori Takeda ◽  
Yoshihiro Mise ◽  
Yu Takahashi ◽  
Hiromichi Ito ◽  
Yosuke Inoue ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Prognostic Value ◽  
Colorectal Liver Metastases

Prognostic Value of Varying Definitions of Positive Resection Margin in Patients with Colorectal Liver Metastases

2017 ◽  
Vol 225 (4) ◽  
pp. e128-e129
Author(s):  
Georgios Antonios Margonis ◽  
Neda Amini ◽  
Jane Wang ◽  
Nikolaos Andreatos ◽  
Neda Rezaee ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Resection Margin ◽  
Positive Resection Margin

scholarly journals The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study

2021 ◽  
Author(s):  
Long Bai ◽  
Ze-Yu Lin ◽  
Yun-Xin Lu ◽  
Qin Chen ◽  
Han Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lactate Dehydrogenase ◽  
Liver Metastases ◽  
Peer Review ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Curative Intent ◽  
Preoperative Serum ◽  
Colorectal Cancer Patients

Abstract Background. The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of curative-intent surgery for colorectal liver metastases (CRLM).Patients and Methods. 580 consecutive metastatic colorectal cancer patients who underwent curative-intent CRLM resection from Blinded for peer review (434 patients) and Blinded for peer review (146 patients) treated in 2000-2019 were enrolled. Overall survival (OS) was the primary endpoint. Cox regression model was performed to identify the prognostic values of preoperative serum LDH levels and other clinicopathology variables. A modification of the established Fong CRS scoring system comprising LDH was developed within this Chinese population.Results. At the median follow-up time of 60.5 months, and median OS was 59.5 months in the pooled cohort. In the multivariate analysis, preoperative LDH > upper limit of normal (250 U/L) was the strongest independent prognostic factor for OS (HR 1.73, 95% confidence interval [CI], 1.22-2.44; P < .001). Patients with elevated LDH levels showed impaired OS than patients with normal LDH levels (27.6 months vs. 68.8 months). Five-year survival rates were 53.7% and 22.5% in the LDH-normal group and LDH-high group, respectively. Similar results were also confirmed in each cohort. In the subgroup analysis, LDH could distinguish the survival regardless of most established prognostic factors (number and size of CRLM, surgical margin, extrahepatic metastases, CEA and CA19-9 levels, etc.). Integrating LDH into the Fong score contributed to an improvement in the predictive value. Conclusion. Our study implicates serum LDH as a reliable and independent laboratory biomarker to predict the clinical outcome of curative-intent surgery for CRLM. Composite of LDH and Fong score is a potential stratification tool for CRLM resection. Prospective, international studies are needed to validate these results across diverse populations.

scholarly journals Prognostic value of sarcopenia in patients with colorectal liver metastases undergoing hepatic resection

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yueh-Wei Liu ◽  
Chien-Chang Lu ◽  
Ching-Di Chang ◽  
Ko-Chao Lee ◽  
Hong Hwa Chen ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Hepatic Resection ◽  
Prognostic Value ◽  
Colorectal Liver Metastases

scholarly journals Comparison of the prognostic value of systemic inflammatory indices in patients with resectable colorectal liver metastases

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e722-e723
Author(s):  
C.P. Neal ◽  
V. Cairns ◽  
M. Jones ◽  
G. Garcea ◽  
A.R. Dennison
Keyword(s):  
Liver Metastases ◽  
Prognostic Value ◽  
Colorectal Liver Metastases

Histological growth pattern as a potential marker of oligometastatic disease in patients operated for colorectal liver metastases.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15093-e15093
Author(s):  
Ali Bohlok ◽  
Robin Dezes ◽  
Valerio Lucidi ◽  
Fikri Bouazza ◽  
Desislava Germanova ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Growth Pattern ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Surrogate Marker ◽  
Oncological Outcome ◽  
International Consensus ◽  
Dominant Phenotype ◽  
Potential Marker ◽  
Surgical Data

e15093 Background: The identification of oligometastatic profile in patients with resectable colorectal liver metastases (CRLM) would represent a major progress to improve selection for surgery. Currently, in the absence of biomarkers, the most reliable method to identify oligometastatic (OLM) and non-oligometastatic (NOLM) tumors relies on the oncological outcome after metastases-targeted surgery. The histological growth pattern (HGP) of CRLM, defined as desmoplastic (dHGP) or replacement (rHGP), has recently been shown to have prognostic value. We analyzed HGP in a series of patients operated for CRLM, characterized as OLM in case of prolonged postoperative recurrence-free survival (RFS) or NOLM in case of rapid postoperative relapse. Methods: In 357 patients operated for CRLM, we identified OLM patients as those with RFS≥5 years (N = 64), and NOLM patients as those with RFS < 1 year (N = 77). Clinicopathologic and surgical parameters were analyzed. In each CRLM, HGP was assessed in archival H&E stained tissue sections, according to international consensus guidelines. Proportions of rHGP and dHGP were determined in each metastasis. In case of multiple metastases, the mean HGP was calculated in each patient. Patients were categorized as pure (> 95% rHGP or dHGP) or dominant phenotypes (> 50% rHGP or dHGP, of the entire tumor-liver interface). Results: Preoperative characteristics of primary tumor and CRLM, and surgical data were identical in OLM and NOLM groups. In a first set of analyses, HGP was determined in 39 OLM and 52 NOLM patients. Pure dHGP was observed in 54.3% of OLM and 17.3% of NOLM patients (p = 0.001). Pure rHGP was similarly distributed among OLM and NOLM groups. Sixty-nine% of the OLM patients displayed a dHGP-dominant phenotype, whereas 57.7% of the NOLM patients presented with a rHGP-dominant phenotype (p = 0.02). Conclusions: These results confirm the potential prognostic value of HGP in patients operated for CRLM. dHGP, associated with angiogenesis and inflammation, could represent a (surrogate) marker for oligometastatic progression, whereas rHGP appears strongly associated with rapid postoperative relapse.

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