scholarly journals Effect of Channel Geometry on Ionic Current Signal of a Bridge Circuit Based Microfluidic Channel

2018 ◽  
Vol 47 (3) ◽  
pp. 350-353 ◽  
Author(s):  
Hirotoshi Yasaki ◽  
Takao Yasui ◽  
Takeshi Yanagida ◽  
Noritada Kaji ◽  
Masaki Kanai ◽  
...  
Keyword(s):  
Bridge Circuit ◽  
Ionic Current ◽  
Microfluidic Channel ◽  
Current Signal ◽  
Channel Geometry

Effects of microfluidic channel geometry on leukocyte rolling assays

2012 ◽  
Vol 15 (1) ◽  
pp. 183-193 ◽  
Author(s):  
Phillip A. Coghill ◽  
Erin K. Kesselhuth ◽  
Eddie A. Shimp ◽  
Damir B. Khismatullin ◽  
David W. Schmidtke
Keyword(s):  
Microfluidic Channel ◽  
Leukocyte Rolling ◽  
Channel Geometry

Electrical Detection of Protein Biomarkers Using Nanoneedle Biosensors

2012 ◽  
Vol 1414 ◽  
Author(s):  
Rahim Esfandyarpour ◽  
Hesaam Esfandyarpour ◽  
Mehdi Javanmard ◽  
James S. Harris ◽  
Ronald W. Davis
Keyword(s):  
Physical Adsorption ◽  
Ionic Current ◽  
Microfluidic Channel ◽  
Protein Detection ◽  
High Sensitivity ◽  
Receptor Protein ◽  
Label Free ◽  
Electrical Detection ◽  
Protein Biomarkers ◽  
Impedance Modulation

Abstract:Here we present the development of an array of electrical nano-biosensors in a microfluidic channel, called Nanoneedle biosensors. Then we present the proof of concept study for protein detection. A Nanoneedle biosensor is a real-time, label-free, direct electrical detection platform, which is capable of high sensitivity detection, measuring the change in ionic current and impedance modulation, due to the presence or reaction of biomolecules such as proteins or nucleic acids. We show that the sensors which have been fabricated and characterized for the protein detection. We have functionalized Nanoneedle biosensors with receptors specific to a target protein using physical adsorption for immobilization. We have used biotinylated bovine serum albumin as the receptor and sterptavidin as the target analyte. The detection of streptavidin binding to the receptor protein is also presented.

Investigation of air-fuel ratio control using ionic current signal

2007 ◽  
Vol 221 (9) ◽  
pp. 1139-1146 ◽  
Author(s):  
X Wu ◽  
K Li ◽  
D Jiang
Keyword(s):  
Control Algorithm ◽  
Closed Loop ◽  
Ionic Current ◽  
Current Signal ◽  
Control Logic ◽  
Fuel Ratio ◽  
Signal Characteristics ◽  
Combustion Region ◽  
The Rich ◽  
Two Peaks

The objective of this paper is to investigate the control of air-fuel ratio (AFR) using an ionic current signal. Experimental measurements have been carried out to study the characteristics of the ionic current signal near ignition poles in a constant-volume combustion bomb. The ionic signal is characterized by a front flame and post flame during combustion. The intensity of the ionic signal strongly depends on the AFR at the time of combustion. The maximum values in both the front flame and the post flame will occur at close to the stoichiometric value. Furthermore, minimum values of the durations from ignition to two peaks will also occur where the AFR is close to the stoichiometric value. From this observation of the ion signal characteristics, a feedback control of AFR in a closed loop is proposed and the algorithm is outlined for detecting whether the mixture is in the lean or the rich combustion condition. Then control logic is given based on the information on lean or rich combustion. A unique condition of combustion around stoichiometry is also discussed. It has been shown that the developed control algorithm covers the entire combustion region: lean, rich, and stoichiometric.

Generative design of microfluidic channel geometry using evolutionary approach

2021 ◽  
Author(s):  
Nikolay O. Nikitin ◽  
Alexander Hvatov ◽  
Iana S. Polonskaia ◽  
Anna V. Kalyuzhnaya ◽  
Georgii V. Grigorev ◽  
...  
Keyword(s):  
Microfluidic Channel ◽  
Evolutionary Approach ◽  
Generative Design ◽  
Channel Geometry

scholarly journals Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout

Gels ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 84 ◽  
Author(s):  
Hsuan-Yu Leu ◽  
Navid Farhoudi ◽  
Christopher Reiche ◽  
Julia Körner ◽  
Swomitra Mohanty ◽  
...  
Keyword(s):  
Response Times ◽  
Low Cost ◽  
Ionic Current ◽  
Microfluidic Channel ◽  
Smart Polymer ◽  
Smart Hydrogel ◽  
Point Of Use ◽  
Water Point ◽  
Hydrogel Swelling ◽  
Target Analyte

There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often suffer from long response times. Hence, we describe here a fabrication process that can be used to manufacture low-cost point-of-use hydrogel-based microfluidics sensors with short response times. In this process, mask-templated UV photopolymerization is used to produce arrays of smart hydrogel pillars inside sub-millimeter channels located upon microfluidics devices. When these pillars contact aqueous solutions containing a target analyte, they swell or shrink, thereby changing the resistance of the microfluidic channel to ionic current flow when a small bias voltage is applied to the system. Hence resistance measurements can be used to transduce hydrogel swelling changes into electrical signals. The only instrumentation required is a simple portable potentiostat that can be operated using a smartphone or a laptop, thus making the system suitable for point of use. Rapid hydrogel response rate is achieved by fabricating arrays of smart hydrogels that have large surface area-to-volume ratios.

Research on the Changing Regularity of Ionic Current and Cylinder Pressure when the Gasoline Engine Knocks

2011 ◽  
Vol 130-134 ◽  
pp. 361-364
Author(s):  
Yue Guo Sun ◽  
Zhao Cheng Yuan ◽  
Li Ying Li ◽  
Shi Yu Li ◽  
Meng Liu
Keyword(s):  
Gasoline Engine ◽  
Ionic Current ◽  
Signal Acquisition ◽  
Cylinder Pressure ◽  
Current Signal ◽  
Ignition System ◽  
Actual Application ◽  
High Tension ◽  
Engine Knock ◽  
And Control

Theoretically speaking, we can achieve the detection and control of the parameters of engine knock and ms-PULSE etc effectively and accurately by analysis the ionic current signals. But in actual application, it is difficult to detect the ionic current signals because of the interference of high pressure from high-tension ignition system. At present, the application of ionic current signal in the detection and control of engine knock is still in the initial early stages. We optimized the signal acquisition system, interference the suppression, achieve the effective detection of ionic current signal in the tests we mentioned in the topic, and then, we analysis and compared the character of ionic current and cylinder pressure signals we collected under different working conditions, exploration and testing is carried out for the further recognition and control of engine knock using the ionic current signals.

scholarly journals Substantial Expansion of Detectable Size Range in Ionic Current Sensing through Pores by Using a Microfluidic Bridge Circuit

2017 ◽  
Vol 139 (40) ◽  
pp. 14137-14142 ◽  
Author(s):  
Hirotoshi Yasaki ◽  
Takao Yasui ◽  
Takeshi Yanagida ◽  
Noritada Kaji ◽  
Masaki Kanai ◽  
...  
Keyword(s):  
Size Range ◽  
Bridge Circuit ◽  
Ionic Current ◽  
Current Sensing

scholarly journals Magnetic Polymer Based Micropumps for Microfluidic Sample Delivery System

2021 ◽  
Vol 85 (1) ◽  
pp. 12-21
Author(s):  
Jumril Yunas ◽  
Muzalifah Mohd Said ◽  
Roer Eka Pawinanto ◽  
Badariah Bais ◽  
Budi Mulyanti ◽  
...  
Keyword(s):  
Magnetic Particles ◽  
Microfluidic Channel ◽  
Electrical Current ◽  
Bonding Process ◽  
Current Signal ◽  
Pump System ◽  
Electromagnetic Coils ◽  
Flow Rate Range ◽  
Large Flow ◽  
Mems Process

In this paper we present the development of electromagnetic (EM) microfluidic pumps incorporating the magnetic polymer composite for the transport of microfluidic bio-sample. The pump system includes the electromagnetic field generator, a flexible actuator membrane made of polymer material with embedded magnetic particles and valve-less microfluidic channel and chamber. The micropump is fabricated using a MEMS process with additional bonding process. Various types of the magnetic membrane as well as electromagnetic coils were fabricated and characterized to find optimum pump performance. As the results, it is found that the fabricated pump systems were able to deliver fluidic sample within a large flow-rate range from 6 ml/min down to several nl/min which can be adjusted by setting the input electrical current parameters, such as intensity, frequency and type of the current signal.

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