The Influence of Muscle Mass on Shear Rate and Brachial Artery Flow Mediated Dilation in the Elderly

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S428
Author(s):  
Devon A. Dobrosielski ◽  
Arturo A. Arce Esquivel ◽  
Kim Landry ◽  
Eric Ravussin ◽  
Michael A. Welsch
Keyword(s):  
Shear Rate ◽  
Muscle Mass ◽  
Brachial Artery ◽  
The Elderly ◽  
Flow Mediated Dilation ◽  
Artery Flow

scholarly journals Brachial Artery Flow-mediated Dilation Following Exercise with Augmented Oscillatory and Retrograde Shear Rate

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Blair D Johnson ◽  
Kieren J Mather ◽  
Sean C Newcomer ◽  
Timothy D Mickleborough ◽  
Janet P Wallace
Keyword(s):  
Shear Rate ◽  
Brachial Artery ◽  
Flow Mediated Dilation ◽  
Artery Flow ◽  
Retrograde Shear

scholarly journals Contribution of nitric oxide to brachial artery vasodilation during progressive handgrip exercise in the elderly

2013 ◽  
Vol 305 (8) ◽  
pp. R893-R899 ◽  
Author(s):  
Joel D. Trinity ◽  
D. Walter Wray ◽  
Melissa A. H. Witman ◽  
Gwenael Layec ◽  
Zachary Barrett-O'Keefe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Shear Rate ◽  
Brachial Artery ◽  
Vascular Function ◽  
The Elderly ◽  
Flow Mediated Dilation ◽  
Handgrip Exercise ◽  
Modest Contribution ◽  
Older Subjects ◽  
The Relationship

The reduction in nitric oxide (NO)-mediated vascular function with age has largely been determined by flow-mediated dilation (FMD). However, in light of recent uncertainty surrounding the NO dependency of FMD and the recognition that brachial artery (BA) vasodilation during handgrip exercise is predominantly NO-mediated in the young, we sought to determine the contribution of NO to BA vasodilation in the elderly using the handgrip paradigm. BA vasodilation during progressive dynamic (1 Hz) handgrip exercise performed at 3, 6, 9, and 12 kg was assessed with and without NO synthase (NOS) inhibition [intra-arterial NG-monomethyl-l-arginine (l-NMMA)] in seven healthy older subjects (69 ± 2 yr). Handgrip exercise in the control condition evoked significant BA vasodilation at 6 (4.7 ± 1.4%), 9 (6.5 ± 2.2%), and 12 kg (9.5 ± 2.7%). NOS inhibition attenuated BA vasodilation, as the first measurable increase in BA diameter did not occur until 9 kg (4.0 ± 1.8%), and the change in BA diameter at 12 kg was reduced by ∼30% (5.1 ± 2.2%), with unaltered shear rate (Control: 407 ± 57, l-NMMA: 427 ± 67 s−1). Although shifted downward, the slope of the relationship between BA diameter and shear rate during handgrip exercise was unchanged (Control: 0.0013 ± 0.0004, l-NMMA: 0.0011 ± 0.007, P = 0.6) as a consequence of NOS inhibition. Thus, progressive handgrip exercise in the elderly evokes a robust BA vasodilation, the magnitude of which was only minimally attenuated following NOS inhibition. This modest contribution of NO to BA vasodilation in the elderly supports the use of the handgrip exercise paradigm to assess NO-dependent vasodilation across the life span.

scholarly journals Fluctuation in shear rate, with unaltered mean shear rate, improves brachial artery flow-mediated dilation in healthy, young men

2019 ◽  
Vol 126 (6) ◽  
pp. 1687-1693 ◽  
Author(s):  
Sophie M. Holder ◽  
Ellen A. Dawson ◽  
Áine Brislane ◽  
Jonny Hisdal ◽  
Daniel J. Green ◽  
...  
Keyword(s):  
Shear Stress ◽  
Shear Rate ◽  
Endothelial Function ◽  
Brachial Artery ◽  
Negative Pressure ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Flow Mediated Dilation ◽  
Conduit Artery ◽  
Artery Flow

Increase in mean shear stress represents an important and potent hemodynamic stimulus to improve conduit artery endothelial function in humans. No previous study has examined whether fluctuations in shear rate patterns, without altering mean shear stress, impacts conduit artery endothelial function. This study examined the hypothesis that 30-min exposure to fluctuations in shear rate patterns, in the presence of unaltered mean shear rate, improves brachial artery flow-mediated dilation. Fifteen healthy men (27.3 ± 5.0 yr) completed the study. Bilateral brachial artery flow-mediated dilation was assessed before and after unilateral exposure to 30 min of intermittent negative pressure (10 s, −40mmHg; 7 s, 0 mmHg) to induce fluctuation in shear rate, while the contralateral arm was exposed to a resting period. Negative pressure significantly increased shear rate, followed by a decrease in shear rate upon pressure release (both P < 0.001). Across the 30-min intervention, mean shear rate was not different compared with baseline ( P = 0.458). A linear mixed model revealed a significant effect of time observed for flow-mediated dilation ( P = 0.029), with exploratory post hoc analysis showing an increase in the intervention arm (∆FMD +2.0%, P = 0.008), but not in the contralateral control arm (∆FMD +0.5%, P = 0.664). However, there was no effect for arm ( P = 0.619) or interaction effect ( P = 0.096). In conclusion, we found that fluctuations in shear patterns, with unaltered mean shear, improves brachial artery flow-mediated dilation. These novel data suggest that fluctuations in shear pattern, even in the absence of altered mean shear, represent a stimulus to acute change in endothelial function in healthy individuals. NEW & NOTEWORTHY Intermittent negative pressure applied to the forearm induced significant fluctuations in antegrade and retrograde shear rate, while mean shear was preserved relative to baseline. Our exploratory study revealed that brachial artery flow-mediated dilation was significantly improved following 30-min exposure to intermittent negative pressure. Fluctuations in blood flow or shear rate, with unaltered mean shear, may have important implications for vascular health; however, further research is required to identify the underlying mechanisms and potential long-term health benefits.

Aerobic exercise acutely prevents the endothelial dysfunction induced by mental stress among subjects with metabolic syndrome: the role of shear rate

2014 ◽  
Vol 306 (7) ◽  
pp. H963-H971 ◽  
Author(s):  
Allan R. K. Sales ◽  
Igor A. Fernandes ◽  
Natália G. Rocha ◽  
Lucas S. Costa ◽  
Helena N. M. Rocha ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Shear Rate ◽  
Endothelial Dysfunction ◽  
Aerobic Exercise ◽  
Brachial Artery ◽  
Mental Stress ◽  
Stress Test ◽  
Flow Mediated Dilation ◽  
Artery Flow

Mental stress induces transient endothelial dysfunction, which is an important finding for subjects at cardiometabolic risk. Thus, we tested whether aerobic exercise prevents this dysfunction among subjects with metabolic syndrome (MetS) and whether an increase in shear rate during exercise plays a role in this phenomenon. Subjects with MetS participated in two protocols. In protocol 1 ( n = 16), endothelial function was assessed using brachial artery flow-mediated dilation (FMD). Subjects then underwent a mental stress test followed by either 40 min of leg cycling or rest across two randomized sessions. FMD was assessed again at 30 and 60 min after exercise or rest, with a second mental stress test in between. Mental stress reduced FMD at 30 and 60 min after the rest session (baseline: 7.7 ± 0.4%, 30 min: 5.4 ± 0.5%, and 60 min: 3.9 ± 0.5%, P < 0.05 vs. baseline), whereas exercise prevented this reduction (baseline: 7.5 ± 0.4%, 30 min: 7.2 ± 0.7%, and 60 min: 8.7 ± 0.8%, P > 0.05 vs. baseline). Protocol 2 ( n = 5) was similar to protocol 1 except that the first period of mental stress was followed by either exercise in which the brachial artery shear rate was attenuated via forearm cuff inflation or exercise without a cuff. Noncuffed exercise prevented the reduction in FMD (baseline: 7.5 ± 0.7%, 30 min: 7.0 ± 0.7%, and 60 min: 8.7 ± 0.8%, P > 0.05 vs. baseline), whereas cuffed exercise failed to prevent this reduction (baseline: 7.5 ± 0.6%, 30 min: 5.4 ± 0.8%, and 60 min: 4.1 ± 0.9%, P < 0.05 vs. baseline). In conclusion, exercise prevented mental stress-induced endothelial dysfunction among subjects with MetS, and an increase in shear rate during exercise mediated this effect.

P8.08 THE RELATIONSHIP BETWEEN BRACHIAL ARTERY FLOW-MEDIATED DILATION AND SHEAR RATE IN INDIVIDUALS WITH INCREASED CARDIOVASCULAR RISK

2011 ◽  
Vol 5 (4) ◽  
pp. 184
Author(s):  
K. Aizawa ◽  
S. Elyas ◽  
F. D’Abate ◽  
D. Majekolagbe ◽  
A.C. Shore ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Shear Rate ◽  
Brachial Artery ◽  
Flow Mediated Dilation ◽  
Artery Flow ◽  
The Relationship

scholarly journals Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yizhou Wen ◽  
Xianmin Wang ◽  
Yonghong Guo ◽  
Mei Jin ◽  
Jimei Xi ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Brachial Artery ◽  
Characteristic Curve ◽  
Coronary Aneurysm ◽  
Acute Stage ◽  
Flow Mediated Dilation ◽  
Strong Negative Correlation ◽  
Coronary Artery Abnormality ◽  
Artery Flow

AbstractCoronary artery abnormalities (CAAs) are a severe complication of Kawasaki disease (KD) that may lead to cardiovascular events. Given the evidence that brachial artery flow-mediated dilation (FMD) decreases in children after the onset of KD, we hypothesized that it could be an early marker of CAA development in the acute stage and investigated its relationship with variation in the coronary artery diameter. A total of 326 sex- and age-matched children were enrolled, including 120 with KD, 109 febrile children and 97 healthy controls. In this study, FMD was significantly decreased in the KD group compared with the febrile and healthy groups. FMD was lower in the CAA group than in the no coronary artery abnormality group. The comparison of FMD showed an obvious difference among the CAA subgroups. The FMD in the coronary aneurysm (CA) group showed a strong negative correlation with the pretreatment maximum coronary artery Z-score (preZmax). While preZmax was 2.5, the receiver operating characteristic curve indicated an optimal cutoff point of 3.44% for FMD. FMD ≤ 3.44% could be considered as a signal of coronary lesions in acute stage of KD.

scholarly journals Geographic Origin as a Determinant of Carotid Artery Intima-Media Thickness and Brachial Artery Flow-Mediated Dilation

2005 ◽  
Vol 25 (2) ◽  
pp. 392-398 ◽  
Author(s):  
Markus Juonala ◽  
Jorma S.A. Viikari ◽  
Mika Kähönen ◽  
Leena Taittonen ◽  
Tapani Rönnemaa ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Brachial Artery ◽  
Geographic Origin ◽  
Intima Media Thickness ◽  
Flow Mediated Dilation ◽  
Media Thickness ◽  
Artery Flow

The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia

2009 ◽  
Vol 107 (4) ◽  
pp. 445-453 ◽  
Author(s):  
Ryan A. Harris ◽  
Steven K. Nishiyama ◽  
D. Walter Wray ◽  
Vince Tedjasaputra ◽  
Damian M. Bailey ◽  
...  
Keyword(s):  
Brachial Artery ◽  
Flow Mediated Dilation ◽  
Artery Flow

Are the dynamic response characteristics of brachial artery flow-mediated dilation sensitive to the magnitude of increase in shear stimulus?

2008 ◽  
Vol 105 (1) ◽  
pp. 282-292 ◽  
Author(s):  
K. E. Pyke ◽  
J. A. Hartnett ◽  
M. E. Tschakovsky
Keyword(s):  
Shear Stress ◽  
Shear Rate ◽  
Dynamic Response ◽  
Phase I ◽  
Brachial Artery ◽  
Flow Mediated Dilation ◽  
Final Phase ◽  
Stimulus Magnitude ◽  
Brachial Artery Diameter ◽  
Response Characteristics

The purpose of this study was to determine the dynamic characteristics of brachial artery dilation in response to step increases in shear stress [flow-mediated dilation (FMD)]. Brachial artery diameter (BAD) and mean blood velocity (MBV) (Doppler ultrasound) were obtained in 15 healthy subjects. Step increases in MBV at two shear stimulus magnitudes were investigated: large (L; maximal MBV attainable), and small (S; MBV at 50% of the large step). Increase in shear rate (estimate of shear stress: MBV/BAD) was 76.8 ± 15.6 s−1 for L and 41.4 ± 8.7 s−1 for S. The peak %FMD was 14.5 ± 3.8% for L and 5.7 ± 2.1% for S ( P < 0.001). Both the L (all subjects) and the S step trials (12 of 15 subjects) elicited a biphasic diameter response with a fast initial phase (phase I) followed by a slower final phase. Relative contribution of phase I to total FMD when two phases occurred was not sensitive to shear rate magnitude ( r2 = 0.003, slope P = 0.775). Parameters quantifying the dynamics of the FMD response [time delay (TD), time constant (τ)] were also not sensitive to shear rate magnitude for both phases (phase I: TD r2 = 0.03, slope P = 0.376, τ r2 = 0.04, slope P = 0.261; final phase: TD r2 = 0.07, slope P = 0.169, τ r2 = 0.07, slope P = 0.996). These data support the existence of two distinct mechanisms, or sets of mechanisms, in the human conduit artery FMD response that are proportionally sensitive to shear stimulus magnitude and whose dynamic response is not sensitive to shear stimulus magnitude.

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