Age-related Changes in Skeletal Muscle Mitochondrial Function: Influence of Lifelong Voluntary Physical Activity

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S243
Author(s):  
Pedro A. Figueiredo ◽  
Rita M. Ferreira ◽  
Maria P. Mota ◽  
Hans J. Appell ◽  
José A. Duarte
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Age Related ◽  
Voluntary Physical Activity ◽  
Age Related Changes

scholarly journals In vivo mitochondrial function in aging skeletal muscle: capacity, flux, and patterns of use

2016 ◽  
Vol 121 (4) ◽  
pp. 996-1003 ◽  
Author(s):  
Jane A. Kent ◽  
Liam F. Fitzgerald
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle ◽  
Oxidative Capacity ◽  
Mitochondrial Content ◽  
Atp Production ◽  
Age Related ◽  
Age Related Changes

Because of the fundamental dependence of mammalian life on adequate mitochondrial function, the question of how and why mitochondria change in old age is the target of intense study. Given the importance of skeletal muscle for the support of mobility and health, this question extends to the need to understand mitochondrial changes in the muscle of older adults, as well. We and others have focused on clarifying the age-related changes in human skeletal muscle mitochondrial function in vivo. These changes include both the maximal capacity for oxidative production of energy (ATP), as well as the relative use of mitochondrial ATP production for powering muscular activity. It has been known for nearly 50 yr that muscle mitochondrial content is highly plastic; exercise training can induce an ∼2-fold increase in mitochondrial content, while disuse has the opposite effect. Here, we suggest that a portion of the age-related changes in mitochondrial function that have been reported are likely the result of behavioral effects, as physical activity influences have not always been accounted for. Further, there is emerging evidence that various muscles may be affected differently by age-related changes in physical activity and movement patterns. In this review, we will focus on age-related changes in oxidative capacity and flux measured in vivo in human skeletal muscle.

Characterization of the Age-related Changes in Skeletal Muscle Mitochondrial Function

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S407-S408
Author(s):  
Pedro A. Figueiredo ◽  
Rita M. Ferreira ◽  
Maria P. Mota ◽  
Hans J. Appell ◽  
José A. Duarte
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Age Related ◽  
Age Related Changes

Understanding Age-Related Changes in Skeletal Muscle Metabolism: Differences Between Females and Males

2016 ◽  
Vol 36 (1) ◽  
pp. 129-156 ◽  
Author(s):  
Brandon J.F. Gheller ◽  
Emily S. Riddle ◽  
Melinda R. Lem ◽  
Anna E. Thalacker-Mercer
Keyword(s):  
Skeletal Muscle ◽  
Muscle Metabolism ◽  
Skeletal Muscle Metabolism ◽  
Age Related ◽  
Age Related Changes

Age-related changes in glutathione availability and skeletal muscle carbonyl content in healthy rats

2004 ◽  
Vol 39 (2) ◽  
pp. 203-210 ◽  
Author(s):  
Laurent Mosoni ◽  
Denis Breuillé ◽  
Caroline Buffière ◽  
Christiane Obled ◽  
Philippe Patureau Mirand
Keyword(s):  
Skeletal Muscle ◽  
Carbonyl Content ◽  
Age Related ◽  
Age Related Changes

scholarly journals Physical activity in elderly

2015 ◽  
Vol 25 (4) ◽  
pp. 249 ◽  
Author(s):  
Jan Cvecka ◽  
Veronika Tirpakova ◽  
Milan Sedliak ◽  
Helmut Kern ◽  
Winfried Mayr ◽  
...  
Keyword(s):  
Physical Activity ◽  
Electrical Stimulation ◽  
Muscle Mass ◽  
Irreversible Process ◽  
Significant Decline ◽  
Positive Effects ◽  
Age Related ◽  
And Performance ◽  
And Function ◽  
Age Related Changes

Aging is a multifactorial irreversible process associated with significant decline in muscle mass and neuromuscular functions. One of the most efficient methods to counteract age-related changes in muscle mass and function is physical exercise. An alternative effective intervention to improve muscle structure and performance is electrical stimulation. In the present work we present the positive effects of physical activity in elderly and a study where the effects of a 8-week period of functional electrical stimulation and strength training with proprioceptive stimulation in elderly are compared.

Exercise and Mitochondrial Function: Importance and InferenceA Mini Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Vaishali K. ◽  
Nitesh Kumar ◽  
Vanishree Rao ◽  
Rakesh Krishna Kovela ◽  
Mukesh Kumar Sinha
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Skeletal Muscles ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Present Review ◽  
Age Related ◽  
Exercise Induced ◽  
Mitochondrial Adaptations

: Skeletal muscles must generate and distribute energy properly in order to function perfectly. Mitochondria in skeletal muscle cells form vast networks to meet this need, and their functions may improve as a result of exercise. In the present review, we discussed exercise-induced mitochondrial adaptations, age-related mitochondrial decline, and a biomarker as a mitochondrial function indicator and exercise interference.

scholarly journals Age-related changes in skeletal muscle: changes to life-style as a therapy

2018 ◽  
Vol 19 (6) ◽  
pp. 519-536 ◽  
Author(s):  
Rachel McCormick ◽  
Aphrodite Vasilaki
Keyword(s):  
Skeletal Muscle ◽  
Life Style ◽  
Age Related ◽  
Muscle Changes ◽  
Age Related Changes

scholarly journals Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesized collagen in regulating collagen production

1991 ◽  
Vol 276 (2) ◽  
pp. 307-313 ◽  
Author(s):  
P K Mays ◽  
R J McAnulty ◽  
J S Campa ◽  
G J Laurent
Keyword(s):  
Skeletal Muscle ◽  
Collagen Synthesis ◽  
Rat Tissues ◽  
Age Related ◽  
Developmental Growth ◽  
Cross Links ◽  
Fractional Synthesis ◽  
Synthesis And Degradation ◽  
Age Related Changes

During developmental growth, collagens are believed to be continuously deposited into an extracellular matrix which is increasingly stabilized by the formation of covalent cross-links throughout life. However, the age-related changes in rates of synthetic and degradative processes are less well understood. In the present study we measured rates of collagen synthesis in vivo using a flooding dose of unlabelled proline given with [14C]proline and determining production of hydroxy[14C]proline. Degradation of newly synthesized collagen was estimated from the amount of free hydroxy [14C]proline in tissues 30 min after injection. Collagen fractional synthesis rates ranged from about 5%/day in skeletal muscle to 20%/day in hearts of rats aged 1 month. At 15 months of age, collagen fractional synthesis rates had decreased markedly in lung and skin, but in skeletal muscle and heart, rates were unchanged. At 24 months of age, synthesis rates had decreased by at least 10-fold in all tissues, compared with rates at 1 month. The proportion of newly synthesized collagen degraded ranged from 6.4 +/- 0.4% in skin to 61.6 +/- 5.0% in heart at 1 month of age. During aging the proportion degraded increased in all tissues to maximal values at 15 months, ranging from 56 +/- 7% in skin to 96 +/- 1% in heart. These data suggest that there are marked age-related changes in rates of collagen metabolism. They also indicate that synthesis is active even in old animals, where the bulk of collagens produced are destined to be degraded.

scholarly journals The Impact of Long‐Term Physical Activity on Age‐Related Changes in Protein and Gene Expression

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Ian R Lanza ◽  
Daniel K Short ◽  
Kevin R Short ◽  
Yan W Asmann ◽  
Sreekumar Raghavakaimal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Age Related ◽  
The Impact ◽  
Age Related Changes
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