Effects of a High Protein Diet on Weight Loss and Body Composition in Sedentary Women with Normal Insulin Sensitivity and Insulin Resistance

OBJECTIVE The fat mass and obesity-associated gene (FTO) variant has shown the strongest association with obesity. Recent studies suggest that dietary intake may modify the genetic effects of FTO. We tested the effect of FTO variant on long-term weight loss and change in body composition in a 2-year randomized intervention trial. RESEARCH DESIGN AND METHODS FTO SNP rs1558902 was genotyped in 742 overweight or obese adults who were randomly assigned to one of four diets differing in the percentages of energy derived from fat, protein and carbohydrate (20, 15, and 65%; 20, 25, and 55%; 40, 15, and 45%; and 40, 25, and 35%) in the Pounds Lost Trial for 2 years. Body composition and fat distribution were measured in 424 and 195 participants by Dual-energy X-ray absorptiometry (DXA) and computed tomography (CT), respectively. RESULTS We found significant modification effects for diet intervention varying in protein (low vs high), but not in fat, on 2-year changes in total fat, fat free mass (FFM), fat mass% (FM%), trunk fat%, total adipose tissue mass (TAT), visceral adipose tissue mass (VAT) and superficial adipose tissue mass (SAT) (P for interactions=0.045, 0.036, 0.033, 0.048, 0.001, 0.008 and 0.002, respectively). Carriers of the risk allele (A allele) had a greater loss of weight and regional fat in response to high protein diet, while an opposite genetic effect was observed on changes in TAT and SAT in response to low protein diet at 2 years. Significant gene by diet interventions (low vs high protein) were also observed at 6 months of intervention, when the maximum of weight-loss was achieved, for changes in FFM, TAT, VAT and SAT (P for interactions=0.007, 0.019, 0.036 and 0.041, respectively). Patterns of change in body composition and fat distribution by diet intervention were similar at 6 month and 2 year. CONCLUSIONS Our data suggest that a high-protein diet may be beneficial for weight loss in individuals with the risk allele of the FTO variant rs1558902.

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Paternal high protein diet modulates body composition, insulin sensitivity, epigenetics, and gut microbiota intergenerationally in rats

The FASEB Journal ◽

10.1096/fj.202100198rr ◽

2021 ◽

Vol 35 (9) ◽

Author(s):

Faye Chleilat ◽

Alana Schick ◽

Julie M. Deleemans ◽

Kyle Ma ◽

Erna Alukic ◽

...

Keyword(s):

Body Composition ◽

Insulin Sensitivity ◽

Gut Microbiota ◽

High Protein Diet ◽

High Protein ◽

Protein Diet

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Effects of a High Protein Diet on Weight Loss and Leptin Levels in Sedentary Women with Normal and Elevated Leptin

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000389332.46527.9c ◽

2010 ◽

Vol 42 ◽

pp. 48

Author(s):

Andrew Jagim ◽

Jonathan M. Oliver ◽

Julie Y. Kresta ◽

Claire N. Canon ◽

Mike Byrd ◽

...

Keyword(s):

Weight Loss ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Sedentary Women

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Changes in body composition with a hypocaloric high-protein diet combined with sedentary, moderate and high-intense physical activity in overweight or obese males: a 6-month randomized controlled trial

10.21203/rs.3.rs-25907/v1 ◽

2020 ◽

Author(s):

Alberto Hernández-Reyes ◽

A. Vidal ◽

F. Cámara-Martos ◽

R. Molina-Luque ◽

R. Moreno-Rojas

Keyword(s):

Physical Activity ◽

Weight Loss ◽

Body Composition ◽

High Intensity ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Activity Group ◽

Physical Activity Group ◽

Intense Physical Activity

Abstract Objectives Although the effectiveness of high-intensity training has been widely recognized as positive in athletes, its application in a clinical context is not well established. There is enough evidence to confirm that high-intensity routines are safe and that at-risk populations, such as for overweight and obese subjects, can help from these weight loss treatments. The purpose of this study was to lead a trial to test whether manipulation of physical activity in extension to high protein diet intake would induce changes in total weight and body composition. Methods Sixty-eight healthy male volunteers were randomly assigned to one of the experimental groups: a control group with a low-level prescription of physical activity (1–4 METs), moderate physical activity group that performed 10.000 steps walking per day (5–8 METs) and intense physical activity group that trained exercises by at least 70% of VO2max three times a week (> 8 METs). All subjects followed a high-protein diet designed with a reduction of 500 kcal/day. Nutritional counseling was provided throughout the study period to help ensure dietary adherence. This intervention was delivered over twenty-four sessions as weekly one-on-one, face-to-face 30-min consultations. Results A significant reduction in body fat percentage was observed in the intense physical activity group (-20.9 ± 8.8 (CI95%: -25.6 – -16.2), p < 0.001). The change in muscle mass did not produce any significant differences between groups (p > 0.05). Concerning weight, a notable weight loss was found in those subjects who performed moderate or intense physical exercise, vs. those who did light exercise, (p < 0.001) and (p < 0.003), respectively. Conclusion our data strongly suggest that resistance training should be included, whenever possible, in any dietary treatment for improving the body composition of men with overweight or obesity.

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The Effects of a High-Protein Diet on Bone Mineral Density in Exercise-Trained Women: A 1-Year Investigation

Journal of Functional Morphology and Kinesiology ◽

10.3390/jfmk3040062 ◽

2018 ◽

Vol 3 (4) ◽

pp. 62

Author(s):

Jose Antonio ◽

Anya Ellerbroek ◽

Cassandra Carson

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Bone Mineral ◽

Mineral Content ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Whole Body ◽

Mineral Density ◽

One Year

The effects of long-term high-protein consumption (i.e., >2.2 g/kg/day) are unclear as it relates to bone mineral content. Thus, the primary endpoint of this investigation was to determine if consuming a high-protein diet for one year affected various parameters of body composition in exercise-trained women. This investigation is a follow-up to a prior 6-month study. Subjects were instructed to consume a high-protein diet (>2.2 g/kg/day) for one year. Body composition was assessed via dual-energy X-ray absorptiometry (DXA). Subjects were instructed to keep a food diary (i.e., log their food ~three days per week for a year) via the mobile app MyFitnessPal®. Furthermore, a subset of subjects had their blood analyzed (i.e., basic metabolic panel). Subjects consumed a high-protein diet for one year (mean ± SD: 2.3 ± 1.1 grams per kilogram body weight daily [g/kg/day]). There were no significant changes for any measure of body composition over the course of the year (i.e., body weight, fat mass, lean body mass, percent fat, whole body bone mineral content, whole body T-score, whole body bone mineral density, lumbar bone mineral content, lumbar bone mineral density and lumbar T-score). In addition, we found no adverse effects on kidney function. Based on this 1-year within-subjects investigation, it is evident that a diet high in protein has no adverse effects on bone mineral density or kidney function.

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The PROMOTE study (High-protein and resistance-training combination in overweight and obesity) for short-term weight loss and long-term weight maintenance for Chinese people: a protocol for a pilot randomized controlled trial

Trials ◽

10.1186/s13063-019-3954-7 ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Shaoyong Xu ◽

Juan Zhang ◽

Yuxiang Dong ◽

Ruikun Chen ◽

Wenlei Xu ◽

...

Keyword(s):

Weight Loss ◽

Resistance Training ◽

Controlled Trial ◽

Weight Maintenance ◽

High Protein Diet ◽

Diet Group ◽

High Protein ◽

Protein Diet ◽

Short Term ◽

Low Fat Diet

Abstract Background It is very important for clinicians and dieticians to explore reasonable weight management strategies for obese people that address both short-term weight loss and subsequent weight maintenance. We hypothesized that resistance training combined with a high-protein diet would result in similar short-term weight loss but better long-term weight maintenance than either a conventional low-fat diet control or a high-protein diet alone. Methods/design This is an 8-week randomized parallel controlled trial followed by a 24-week observational follow-up study. A 48-week supplementary follow-up study will be carried out if necessary. The study will be conducted between June 2019 and October 2020. The 90 overweight or obese participants will be randomly assigned to the conventional low-fat diet group, the high-protein diet group and the high-protein diet and resistance training combination group. Primary outcomes are body weight change at week 8 and week 24 compared with the baseline level. Discussion High-quality research on the effect of a high-protein diet combined resistance training on weight loss and weight maintenance is limited in the Chinese population. Our study will provide a basis for obesity management in China and will promote the development of exercise- and diet-related studies. Trial registration Chinese Clinical Trial Registry, ChiCTR1900023841. Registered on 14 June 2019.

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The effect of choice feeding during the rearing period on reproductive function in the gilt

Proceedings of the British Society of Animal Science ◽

10.1017/s1752756200001034 ◽

2000 ◽

Vol 2000 ◽

pp. 102-102 ◽

Cited By ~ 1

Author(s):

S. R. L. Lucas ◽

J. A. Rooke ◽

V. C. Bland ◽

A.G. Sinclair ◽

S. A. Edwards

Keyword(s):

Body Composition ◽

Reproductive Function ◽

High Protein Diet ◽

Diet Selection ◽

Growing Pigs ◽

High Protein ◽

Protein Source ◽

Protein Diet ◽

Choice Feeding ◽

Growth And Reproduction

Previous studies (e.g. Cia et al. 1998) have shown that modification of body composition of the prepubertal gilt has effects on responsiveness of gilts to exogenous gonadotrophin. Growing pigs are able to select a diet from different foods differing in protein:energy ratio (Dalby 1998); however there is little evidence of what effect the conflicting nutritional demands of growth and reproduction have on diet selection. The objectives of the experiment were to quantify the effects of choice feeding on responsiveness of gilts to exogenous gonadotrophin (Cia et al. 1998) and to investigate the effect of protein source on diet selection as Jones et al.(2000) have observed selection by breeding gilts against a high protein diet containing fishmeal.

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