Accelerated Recovery OF Skeletal Muscle Damage After Eccentric Exercise By BCAA Supplementation

ABSTRACT Polymethoxyflavones (PMFs) contained in the peel of citrus fruits have anti-inflammatory, anticancer, and antidepressant effects. However, their effects on skeletal muscle are unknown. We investigated whether PMFs could prevent skeletal muscle damage induced by eccentric exercise in rats. Downhill running for 90 min increased the levels of the inflammatory cytokines, monocyte chemotactic protein-1 (MCP-1), and interleukin-1β (IL-1β) in skeletal muscles, especially in vastus lateralis, and the plasma creatine kinase levels. These increases were attenuated by a single oral administration of orange peel extract (OPE) 30 min before downhill running. A mixture of nobiletin, sinensetin, 3,5,6,7,8,3′,4′-heptamethoxyflavone, and tangeretin, which are the major PMFs of OPE, also showed similar effects on muscle damage. These results suggest that OPE has a protective effect against eccentric exercise-induced skeletal muscle damage, and that the effects may be attributed to the 4 major PMFs.

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Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation

Expert Review of Respiratory Medicine ◽

10.1080/17476348.2021.1893169 ◽

2021 ◽

pp. 1-14

Author(s):

Rebeca Nunes Silva ◽

Cássia Da Luz Goulart ◽

Murilo Rezende Oliveira ◽

Guilherme Yassuyuki Tacao ◽

Guilherme Dionir Back ◽

...

Keyword(s):

Skeletal Muscle ◽

Muscle Damage ◽

Skeletal Muscle Damage ◽

Urgent Case

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Modifications in the Concentrations of Circulating Myoglobin after Treatment with Low Doses of Adriamycin

Tumori Journal ◽

10.1177/030089168507100509 ◽

1985 ◽

Vol 71 (5) ◽

pp. 463-468 ◽

Cited By ~ 1

Author(s):

Giovanni Carulli ◽

Aldo Clerico ◽

Alessandra Marini ◽

Maria Grazia Del Chicca ◽

Renato Vanacore ◽

...

Keyword(s):

Skeletal Muscle ◽

Creatine Kinase ◽

Cancer Patients ◽

Muscle Damage ◽

Low Doses ◽

Skeletal Muscle Damage ◽

Creatine Kinase Mb

The modifications in the concentration of circulating myoglobin have been studied by means of a radioimmunoassay in 15 cancer patients undergoing polychemotherapy including adriamycin. In 8 patients significant increases in myoglobin levels were found after injection of low doses of the drug (25-50 mg/m2). Moreover, a disturbance of the normal biorhythm of the protein was evident in 12 patients. Creatine kinase-MB was evaluated by means of a radioimmunoassay, but there was no relation between an increase in the isoenzyme and an increase in myoglobin. No ECG modifications were detected. These data indicate that the measurement of myoglobin may offer an indication of myocardial or skeletal muscle damage caused by adriamycin.

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Isoform specific ALT measurement during liver and skeletal muscle damage

Toxicology Letters ◽

10.1016/j.toxlet.2012.03.194 ◽

2012 ◽

Vol 211 ◽

pp. S48

Author(s):

Björn Glinghammar ◽

Ingalill Rafter ◽

Ina Schuppe-Koistinen ◽

Ian Cotgreave

Keyword(s):

Skeletal Muscle ◽

Muscle Damage ◽

Skeletal Muscle Damage

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Toll-Like Receptors in Ischaemia and Its Potential Role in the Pathophysiology of Muscle Damage in Critical Limb Ischaemia

Cardiology Research and Practice ◽

10.1155/2012/121237 ◽

2012 ◽

Vol 2012 ◽

pp. 1-13 ◽

Cited By ~ 19

Author(s):

Hemanshu Patel ◽

Sidney G. Shaw ◽

Xu Shi-Wen ◽

David Abraham ◽

Daryll M. Baker ◽

...

Keyword(s):

Skeletal Muscle ◽

Muscle Damage ◽

Potential Role ◽

Arterial Disease ◽

Severe Form ◽

Tissue Loss ◽

Critical Limb Ischaemia ◽

Limb Ischaemia ◽

Toll Like Receptors ◽

Skeletal Muscle Damage

Toll-like receptors (TLRs) are key receptors of the innate immune system which are expressed on immune and nonimmune cells. They are activated by both pathogen-associated molecular patterns and endogenous ligands. Activation of TLRs culminates in the release of proinflammatory cytokines, chemokines, and apoptosis. Ischaemia and ischaemia/reperfusion (I/R) injury are associated with significant inflammation and tissue damage. There is emerging evidence to suggest that TLRs are involved in mediating ischaemia-induced damage in several organs. Critical limb ischaemia (CLI) is the most severe form of peripheral arterial disease (PAD) and is associated with skeletal muscle damage and tissue loss; however its pathophysiology is poorly understood. This paper will underline the evidence implicating TLRs in the pathophysiology of cerebral, renal, hepatic, myocardial, and skeletal muscle ischaemia and I/R injury and discuss preliminary data that alludes to the potential role of TLRs in the pathophysiology of skeletal muscle damage in CLI.

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