scholarly journals Regulation of cardiac hypertrophy by the formation of G protein-coupled receptor—TRPC channel protein complex

2009 ◽  
Vol 134 (3) ◽  
pp. 131-136 ◽  
Author(s):  
Motohiro Nishida ◽  
Yoji Sato ◽  
Michio Nakaya ◽  
Hitoshi Kurose
Keyword(s):  
Cardiac Hypertrophy ◽  
G Protein ◽  
Protein Complex ◽  
G Protein Coupled Receptor ◽  
Trpc Channel ◽  
Channel Protein ◽  
G Protein Coupled

scholarly journals Cell adhesion controlled by adhesion G protein–coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo–Dock

2017 ◽  
Vol 292 (29) ◽  
pp. 12178-12191 ◽  
Author(s):  
Magda Nohemí Hernández-Vásquez ◽  
Sendi Rafael Adame-García ◽  
Noumeira Hamoud ◽  
Rony Chidiac ◽  
Guadalupe Reyes-Cruz ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
G Protein ◽  
Protein Complex ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G protein-coupled receptor kinase 2 promotes cardiac hypertrophy

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0182110 ◽  
Author(s):  
Philipp Schlegel ◽  
Julia Reinkober ◽  
Eric Meinhardt ◽  
Henrike Tscheschner ◽  
Erhe Gao ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Calcium Signaling, Calcineurin and NFAT3 Molecular Pathway in Reprogramming of Fetal Gene (BNP) Expression in Cardiac Hypertrophy and Inhibitors of Cardiac Hypertrophy-Review

2021 ◽  
Vol 23 (12) ◽  
pp. 270-284
Author(s):  
Kousalya. P ◽  
◽  
Doss VA ◽  
Keyword(s):  
Cardiac Hypertrophy ◽  
Calcium Signaling ◽  
Phosphatase Activity ◽  
G Protein ◽  
Calcium Level ◽  
Calcineurin Inhibitors ◽  
G Protein Coupled Receptor ◽  
Target Region ◽  
Molecular Pathway ◽  
G Protein Coupled

G-Protein Coupled Receptor (GPCR) plays a major role in cardiac hypertrophy. Isoproterenol is an agonist which binds to GPCR. This results in the activation of GS subunit. Activated Gs subunit stimulates cAMP mediated pathway. This activates the calcium signaling and elevates the calcium level. Increased calcium activates the phosphatase activity of calcineurin. Activated calcineurin dephosphorylates NFAT in cytoplasm. Dephosphorylated NFAT translocates to nucleus and binds to target region in DNA and activates re-expression of fetal genes in synergy with GATA-4 trascription factor. Reprogramming of fetal genes by NFAT- 3 and GATA-4 results in cardiac hypertrophy. Calcineurin inhibitors and rephosphorylation of NFAT can prevent cardiac hypertrophy.

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