Ca2+ channels as novel therapeutic targets in heart failure

Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.

Download Full-text

Ion channels as novel therapeutic targets in heart failure

Annals of Medicine ◽

10.1080/07853890510007214 ◽

2005 ◽

Vol 37 (1) ◽

pp. 44-54 ◽

Cited By ~ 23

Author(s):

Fadi G. Akar ◽

Gordon F. Tomaselli

Keyword(s):

Heart Failure ◽

Ion Channels ◽

Therapeutic Targets ◽

Novel Therapeutic

Download Full-text

Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies

Therapeutics and Clinical Risk Management ◽

10.2147/tcrm.s106065 ◽

2016 ◽

pp. 887 ◽

Cited By ~ 10

Author(s):

Kwadwo Osei Bonsu ◽

Isaac .K. Owusu ◽

Kwame .O. Buabeng ◽

Daniel .D. Reidpath ◽

Amudha Kadirvelu

Keyword(s):

Heart Failure ◽

Clinical Studies ◽

Therapeutic Targets ◽

Heart Failure Treatment ◽

Failure Treatment ◽

Novel Therapeutic

Download Full-text

Transient Receptor Potential Channels as Novel Therapeutic Targets of Heart Failure

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2010.07.053 ◽

2010 ◽

Vol 16 (9) ◽

pp. S141

Author(s):

Hiroyuki Watanabe ◽

Hiroshi Ito

Keyword(s):

Heart Failure ◽

Transient Receptor Potential ◽

Therapeutic Targets ◽

Receptor Potential ◽

Transient Receptor Potential Channels ◽

Potential Channels ◽

Transient Receptor ◽

Novel Therapeutic

Download Full-text

A Review of Relevant Therapeutic Targets for the Management of Congestive Heart Failure in Dogs: Present and Future Directions

10.20944/preprints201903.0082.v1 ◽

2019 ◽

Author(s):

Jonathan Mochel

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Therapeutic Targets ◽

Therapeutic Strategies ◽

Present Review ◽

Future Directions ◽

Renin Angiotensin Aldosterone System ◽

Renin Angiotensin ◽

New Findings ◽

Novel Therapeutic

Congestive heart failure (CHF) is a major cause of morbidity and mortality with an increasing prevalence in human and canine populations. Similar to humans, overactivation of the renin-angiotensin aldosterone system is involved in the pathophysiology of CHF in dogs. Current therapeutic strategies for the management of canine CHF include the use of RAAS inhibitors, diuretics and inodilators. The present review summarizes data from our own research on the modulation of the renin-angiotensin cascade in dogs in dogs, together with new findings (including novel therapeutic targets) from the veterinary and the human literature.

Download Full-text