scholarly journals Immunoglobulins and immunoglobulin subclasses in the elderly

Author(s):  
R. J. Lock ◽  
D. J. Unsworth

Background: Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15--18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses. We present reference range data for an elderly UK patient population, for IgG, IgA, IgM and IgG subclasses. Methods: Serum immunoglobulins were reviewed on samples from 1146 patients > 60 years of age and 925 patients aged 18--60 years. Serum IgG subclasses were reviewed on samples from 498 patients >60 years and 484 patients aged 18--60 years. All Igs and subclasses were measured by nephelometry. Reference ranges were derived by probability plotting. Results: Serum median IgG and IgM concentrations are reduced in the elderly (IgG female P < 0·001, IgG male P < 0·03; IgM female P < 0·001, IgM male P < 0·001). Serum IgA concentrations are maintained. Indeed, men showed a slight increase in serum IgA with age ( P = 0·03). Few differences dependent on gender were seen. Median IgM was lower in men in the younger age groups (18--60 years P < 0·001; 61--70 years P = 0·017). IgG2 is reduced in elderly men ( P = 0·002) and IgG, reduced in elderly women ( P = 0·009). Conclusions: We advocate that centres offering these investigations provide local, method-dependent reference ranges, and suggest an approach as to how this might be achieved.

2013 ◽  
Vol 16 (4) ◽  
pp. 930-942 ◽  
Author(s):  
Ione Jayce Ceola Schneider ◽  
Marui Weber Corseuil ◽  
Antonio Fernando Boing ◽  
Eleonora d'Orsi

The purpose of this paper is to describe the knowledge about mammography and to identify associated factors in female adults and elderly. Data were obtained from two population surveys, one with female adults and another with elderly women from Florianópolis (SC) in 2009 - 2010. A descriptive analysis of the variables was carried out, the appropriate mean of responses about mammography was estimated and crude and adjusted Poisson regression was conducted to identify associated factors. Among adults, 23.1% answered all of the questions appropriately and the appropriate average responses was 7.2 (95%CI 7.1 - 7.3) in a total of 9. In the adjusted model, older age, higher education and income were associated with knowledge about mammography. For the elderly, 15.3% answered all questions appropriately and the average of appropriate responses was 6.4 (95%CI 5.2 - 6.5) and the factors associated with knowledge about mammography in the adjusted model were younger age groups, increased education and income, and identification of mammography as the main diagnostic method for breast cancer. Information about mammography can neither be transmitted in a clear way nor be easily understood; there are also demographic and socioeconomic differences concerning the knowledge about the exam.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Aiko Maeda ◽  
Kenzo Araki ◽  
Chiaki Yamada ◽  
Shoko Nakayama ◽  
Kazuhiro Shirozu ◽  
...  

Abstract Background Hyperactive dysfunction syndrome (HDS) refers to a constellation of symptoms developing from cranial nerve overactivity caused by neurovascular compression at the root entry or exit zone near the brainstem. Although the combined features of HDS are seen in the elderly, there are no reports of such cases in adolescents, to date. Case presentation A 17-year-old male was diagnosed with right glossopharyngeal neuralgia and treated with microvascular decompression. He experienced new-onset right facial pain later and was diagnosed with right trigeminal neuralgia, which required prompt radiofrequency thermocoagulation of the right mandibular nerve. Follow-up in the third post-treatment year revealed the absence of symptom recurrence. Discussion We report the treatment of a rare case of adolescent-onset combined HDS presenting as trigeminal and glossopharyngeal neuralgia. This report highlights the possibility of combined hyperactive dysfunction syndrome in younger age groups. It is crucial to establish a diagnosis early on for prompt management.


2020 ◽  
Vol 222 (10) ◽  
pp. 1731-1739 ◽  
Author(s):  
Eleanor Burnett ◽  
Umesh D Parashar ◽  
Jacqueline E Tate

Abstract Background Since 2006, more than 100 countries have introduced rotavirus vaccine into their immunization programs. We reviewed published data on relative reductions of rotavirus hospitalizations, acute gastroenteritis (AGE) hospitalizations, and AGE deaths among children &lt;5 years old. Methods Articles published from January 1, 2006 to December 31, 2019 with at least 12 months of data before and after rotavirus vaccine introduction were included. Relative reductions were abstracted into a standardized form. Descriptive statistics are presented as medians and interquartile ranges (IQRs). Results We reviewed 1827 total records and included 105 articles from 49 countries. Among children &lt;5 years old, there was a median reduction of 59% (IQR, 46–74) in rotavirus hospitalizations, 36% (IQR, 23–47) in AGE hospitalizations, and 36% (IQR, 28–46) AGE mortality. Reductions were larger in countries with low child mortality, among younger age groups, and in countries with higher coverage. The median percentage of specimens that tested positive for rotavirus among children &lt;5 years old hospitalized for diarrhea was 40% (IQR, 28–45) before rotavirus vaccine introduction and 20% (IQR, 20–20) 4 years after introduction. Conclusions Overall, we found sustained impact on rotavirus and AGE hospitalizations and deaths. These results should encourage countries still considering rotavirus vaccine implementation.


Author(s):  
Jinkyung Choi

Dietary supplements (DSs) are typically used by the elderly in a population, but younger age groups are increasingly purchasing these products. In consideration of this issue, the present study investigated the DS-related behaviors and general lifestyles of university students in South Korea. The health conditions, consciousness, involvement, and knowledge, as well as the future behavioral intentions, of DS users and non-users were determined and compared. A survey was administered to the respondents, and measurements were adapted and rephrased to suit the Korean context. Results showed that although the behaviors of DS users and non-users were characterized by similar patterns, significant differences in health involvement and future purchase were found between these groups. Health involvement influenced DSs buying intentions in the future, but no significant differences in the other variables were found. The findings suggested that university students take DSs regardless of their expectations about their efficacy and that their knowledge does not affect their intention to purchase such products.


2014 ◽  
Vol 20 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Eyal Robenshtok ◽  
Carlos Benbassat ◽  
Dania Hirsch ◽  
Gloria Tzvetov ◽  
Zvi Cohen ◽  
...  

2014 ◽  
Vol 5 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Krzysztof Piech ◽  
Jakub Piech ◽  
Juris Grants

Abstract The topic of Nordic walking shows the main points of scientific interest concerning form of physical exercise. Existing research mainly focuses on presenting it as beneficial for the elderly. The authors of the topic are presenting the advantages of pole walking for distinctive age groups. There are a number of publications concerning elderly women specifically. Nordic walking is also an object of interest in biomechanical studies. There is an apparent shortage of publications on the utility of this kind of physical activity for children and the young. This seems to be a frequent shortcoming of the research methodology, as it is difficult to deduce whether the study is based on the correct Nordic walking technique or rather on walking with poles as a bracing device. At the same time there is no data concerning Nordic walking as a competitive sport which has been developing dynamically.


1989 ◽  
Vol 155 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Susan M. Benbow

Electroconvulsive therapy is an important treatment in the depressive states of late life, and there is general agreement about the indications for its use in old age psychiatry. Indeed, old age may be associated with a better response to ECT than that in younger age groups. The additional risk involved through physical problems in the elderly is not great when compared with that of continuing depression and of the side-effects of alternative treatments. Temporary memory disorders and confusion may occur, but are minimised if unilateral electrode placement is used. Some patients treated with unilateral ECT do not respond, but will respond to bilateral treatment. Anxiety over unwanted treatment effects, which can lead to ineffective treatment of depressive illness, must be outweighed by knowledge of the dangers of leaving depression untreated in old age.


2015 ◽  
Vol 43 (2) ◽  
Author(s):  
Hanne Vandenberghe ◽  
Leen d’Haenens ◽  
Baldwin Van Gorp

Demographic diversity in the Flemish press Demographic diversity in the Flemish press This study analyses the diversity of the Flemish news by looking at demographic diversity, i.e. the extent to which gender, age and ethnicity in society are proportionally represented in the news. In a constructed week (April-May 2012) (N = 4,800) 12,743 persons were mentioned, each of them were assigned to age groups, man or woman, ethnic minority or ethnic majority. The results indicate that youngsters, the elderly, women and ethnic minorities are underrepresented as news sources in the Flemish news. Especially in the case of elite sources, the news was strongly dominated by adult ‘white’ men. Women were systematically associated more often with ‘feminine’ topics such as welfare and culture, whereas news topics such as sports, politics or economics were strongly dominated by male actors. Ethnic minorities were predominantly (84,2%) connected to sport, crime and justice, and human rights including immigration.


2020 ◽  
Vol 15 (1) ◽  
pp. 21-23
Author(s):  
Nasir Uddin Ahmed ◽  
Suranjit Kumar Saha ◽  
Kamal Uddin Ahmed ◽  
Gias Uddin Ahmed ◽  
Syed Golam Kibria

Coronary artery atherosclerosis (CAA) leads to ischemic heart disease and that is the most common cause of cardiac deaths worldwide. The incidence is more among the elderly people, but now gradually increasing among the young. The study was done to evaluate the prevalence of CAA in different age group by post-mortem study. An observational study was conducted in the department of Pathology of Faridpur Medical College (FMC). In this study total 53 postmortem histopathological examination of heart were done and analyzed, of them 37 were male and 16 were female. Among all, CAA was found in 8 cases and all were male. Regarding age, 4(50%) cases were in the age group from 41 to 50 years, 3 cases were in age of above 60 years and one case was in the age group from 51 to 60 years. Left CAA was observed in 6(75%) cases, both right and left CAA was found in remaining 2(25%) cases but none was found to involve only right coronary artery. Lowest age of involvement of CAA was 42 years that involved left coronary artery. This study shows that the prevalence of CAA is increasing among the younger age group. Faridpur Med. Coll. J. Jan 2020;15(1): 21-23


2003 ◽  
Vol os10 (2) ◽  
pp. 45-48 ◽  
Author(s):  
A Graham Gilmour ◽  
Claire L Morgan

It is predicted that geriatric patients will dramatically increase in number within our working lives. Although they are considered to demand treatment less frequently than the younger age groups, there are specific issues that need to be considered when providing dental treatment for these patients. The term gerodontics has been coined to describe this subject. The need to consider family relationships and the role of carers may play a greater part in their dental management than that of the general population. As well as oral disease, the incidence of general disease is higher in this population, as is the amount of medication prescribed to treat it; these factors often complicate dental management. Special problems that will have a high dental impact on the geriatric patient may be lack of adaptive potential, poor plaque control, root caries, periodontal breakdown and levels of toothwear.


Sign in / Sign up

Export Citation Format

Share Document