A picture is worth a thousand words: a history of diagnostic imaging for lymphoma

2021 ◽  
pp. 20210285
Author(s):  
N Ari Wijetunga ◽  
Brandon Stuart Imber ◽  
James F Caravelli ◽  
N George Mikhaeel ◽  
Joachim Yahalom
Keyword(s):  
Personalized Medicine ◽  
Imaging Studies ◽  
Time Points ◽  
Anatomical Imaging ◽  
Before And After ◽  
Promising Area ◽  
History Of ◽  
Practical Guidance ◽  
Initial Imaging

The journey from early drawings of Thomas Hodgkin’s patients to deep learning with radiomics in lymphoma has taken nearly 200 years, and in many ways, it parallels the journey of medicine. By tracing the history of imaging in clinical lymphoma practice, we can better understand the motivations for current imaging practices. The earliest imaging modalities of the 2D era, each had varied, site-dependent sensitivity and the accuracy of imaging studies allowing new diagnostic and therapeutic techniques. First, we review the initial imaging technologies that were applied to understand lymphoma spread and achieve practical guidance for the earliest lymphoma treatments. Next, in the 3D era, we describe how anatomical imaging advances replaced and complemented conventional modalities. Afterwards, we discuss how the PET era scans were used to understand response of tumors to treatment and risk stratification. Lastly, we discuss the emergence of radiomics as a promising area of research in personalized medicine. We are now able to identify involved lymph nodes and body sites both before and after treatment to offer patients improved treatment outcomes. As imaging methods continue to improve sensitivity, we will be able to use personalized medicine approaches to give targeted and highly focused therapies at even earlier time-points, and ideally, we can obtain long-term disease control and cures for lymphomas.

scholarly journals Effects of Successive Annual Training on Aerobic Endurance Indices in Young Swimmers

2017 ◽  
Vol 10 (1) ◽  
pp. 214-221 ◽  
Author(s):  
Gavriil G. Arsoniadis ◽  
Petros G. Botonis ◽  
Ioannis S. Nikitakis ◽  
Dimitrios Kalokiris ◽  
Argyris G. Toubekis
Keyword(s):  
Lactate Threshold ◽  
Lactate Concentration ◽  
Front Crawl ◽  
Female Age ◽  
Time Points ◽  
Training Adaptations ◽  
Before And After ◽  
Preparation Period ◽  
The Individual

Background: The magnitude of long-term changes on aerobic endurance indices provides useful information for understanding any training-induced adaptation during maturation. Objective: The aim of the present study was to compare changes in different aerobic endurance indices within two successive training years. Methods: Eight swimmers, (five male, three female; age: 14.1±1.5, height: 163.8±9.9 cm, body mass: 55.8±10 kg) were tested at four time-points, before and after the 12-week specific preparation period, within two successive training years (at year-1: start-1, end-1, at year-2: start-2, end-2). In each time-point were timed in distances of 50, 200 and 400 m front crawl to calculate the critical speed (CS). Subsequently, performed 5x200 m front crawl progressively increasing intensity and the lactate concentration was determined after each repetition. Using the individual speed vs. lactate concentration curve, the speed corresponding to 4 mmol.L-1 concentration (V4) and the speed corresponding to lactate threshold (sLT) were calculated. Results: Aerobic endurance was increased from year-1 to year-2 (effect of time, p<0.05) and no difference was observed between V4, sLT and CS at all time-points of evaluation (p>0.05). In year-1, V4, sLT and CS were unchanged even after the 12-week period (p>0.05). During year-2 of training it was only V4 that was increased from start-2 to end-2 (p<0.05), whereas sLT and CS were unchanged at the same period (p>0.05). Conclusion: The aerobic endurance indices change similarly throughout a two-year training, independent of the maturation. Possibly, V4 is more sensitive to detect training adaptations during the specific preparation period in young swimmers.

scholarly journals Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Erik M Quandt ◽  
Jimmy Gollihar ◽  
Zachary D Blount ◽  
Andrew D Ellington ◽  
George Georgiou ◽  
...  
Keyword(s):  
Citrate Synthase ◽  
Fine Tuning ◽  
Ecological Niches ◽  
Glta Gene ◽  
Evolutionary Changes ◽  
Before And After ◽  
Evolution Experiment ◽  
History Of ◽  
Second Wave

Evolutionary innovations that enable organisms to colonize new ecological niches are rare compared to gradual evolutionary changes in existing traits. We discovered that key mutations in the gltA gene, which encodes citrate synthase (CS), occurred both before and after Escherichia coli gained the ability to grow aerobically on citrate (Cit+ phenotype) during the Lenski long-term evolution experiment. The first gltA mutation, which increases CS activity by disrupting NADH-inhibition of this enzyme, is beneficial for growth on the acetate and contributed to preserving the rudimentary Cit+ trait from extinction when it first evolved. However, after Cit+ was refined by further mutations, this potentiating gltA mutation became deleterious to fitness. A second wave of beneficial gltA mutations then evolved that reduced CS activity to below the ancestral level. Thus, dynamic reorganization of central metabolism made colonizing this new nutrient niche contingent on both co-opting and overcoming a history of prior adaptation.

Priming-Induced Shift in Synaptic Plasticity in the Rat Hippocampus

1999 ◽  
Vol 82 (4) ◽  
pp. 2024-2028 ◽  
Author(s):  
Hongyan Wang ◽  
John J. Wagner
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Crossover Point ◽  
Term Potentiation ◽  
Before And After ◽  
History Of ◽  
The Brain ◽  
Dependent Mechanism

The activity history of a given neuron has been suggested to influence its future responses to synaptic input in one prominent model of experience-dependent synaptic plasticity proposed by Bienenstock, Cooper, and Munro (BCM theory). Because plasticity of synaptic plasticity (i.e., metaplasticity) is similar in concept to aspects of the BCM proposal, we have tested the possibility that a form of metaplasticity induced by a priming stimulation protocol might exhibit BCM-like characteristics. CA1 field excitatory postsynaptic potentials (EPSPs) obtained from rat hippocampal slices were used to monitor synaptic responses before and after conditioning stimuli (3–100 Hz) of the Schaffer collateral inputs. A substantial rightward shift (>5-fold) in the frequency threshold between long-term depression (LTD) and long-term potentiation (LTP) was observed <1 h after priming. This change in the LTD/P crossover point occurred at both primed and unprimed synaptic pathways. These results provide new support for the existence of a rapid, heterosynaptic, experience-dependent mechanism that is capable of modifying the synaptic plasticity phenomena that are commonly proposed to be important for developmental and learning/memory processes in the brain.

Histiocytic lesion mimicking intrinsic brainstem neoplasm

1999 ◽  
Vol 91 (6) ◽  
pp. 1037-1040 ◽  
Author(s):  
Kyle D. Weaver ◽  
Diane Armao ◽  
Joseph M. Wiley ◽  
Matthew G. Ewend
Keyword(s):  
Differential Diagnosis ◽  
Fourth Ventricle ◽  
Pathological Examination ◽  
Subtotal Resection ◽  
Imaging Studies ◽  
Content Type ◽  
Brainstem Lesions ◽  
History Of ◽  
Initial Imaging ◽  
Fine Print

✓ This 10-year-old girl presented with a 1-month history of progressive bulbar palsy and a solitary enhancing mass originating within the floor of the fourth ventricle. Results of initial imaging studies and presentation were suggestive of neoplasia. Subtotal resection was performed and pathological examination revealed the mass to be a histiocytic lesion, with no evidence of a glioma. The patient had no other stigmata of histiocytosis and was treated with steroid medications, resulting in prolonged resolution of the lesion. This case demonstrates that for discrete brainstem lesions the differential diagnosis includes entities other than glioma for which treatment is available. Biopsy sampling should be considered when technically feasible.

scholarly journals Clinical efficacy of single intraoperative 500 mg methylprednisolone management therapy for thoracic myelopathy caused by ossification of the ligamentum flavum

2020 ◽  
Author(s):  
Xiaoyang Huo ◽  
Jiaming Zhou ◽  
Shiwei Liu ◽  
Xing Guo ◽  
Yuan Xue
Keyword(s):  
Posterior Approach ◽  
Ligamentum Flavum ◽  
Nerve Function ◽  
Thoracic Myelopathy ◽  
Time Points ◽  
Before And After ◽  
Long Term Follow Up ◽  
Frankel Grade

Abstract Background The objective of our study was to compare clinical outcome and postoperative complications between patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) treated with and without intraoperative methylprednisolone (MP).Methods This retrospective study enrolled 101 patients who underwent posterior approach surgery for OLF and were followed up at least 1 year. Patients were divided into two groups according to MP use in the operation: MP group (n=47) and non-MP group (n=54). Clinical outcomes and complications were evaluated before and after operation and at the last follow-up.Results Significant differences were found in modified Japanese Orthopedics Association (mJOA) scores and proportion of Frankel grade (A-C) between the two groups immediately after surgery and at 2-week follow-up. No significant differences were found between the two groups in mJOA score before operation and at the final follow-up. Moreover, no significant differences were observed in recovery rate according to mJOA score at any time points, and there were no significant differences in the proportion of Frankel grade between the two groups. There were 13 documented infections: 10 in the MP group and 3 in the non-MP group ( P =0.034).Conclusion Management therapy with intraoperative 500 mg methylprednisolone promoted the recovery of nerve function within 2 weeks in patients with thoracic myelopathy caused by OLF. However, long-term follow-up results showed that intraoperative methylprednisolone was inefficient. Moreover, intraoperative methylprednisolone increased the rate of wound infection.

scholarly journals Clinical efficacy of single intraoperative 500 mg methylprednisolone management therapy for thoracic myelopathy caused by ossification of the ligamentum flavum

2020 ◽  
Author(s):  
Xiaoyang Huo ◽  
Jiaming Zhou ◽  
Shiwei Liu ◽  
Xing Guo ◽  
Yuan Xue
Keyword(s):  
Posterior Approach ◽  
Ligamentum Flavum ◽  
Thoracic Myelopathy ◽  
Time Points ◽  
Significant Difference ◽  
Before And After ◽  
Long Term Follow Up ◽  
Frankel Grade

Abstract Background: The objective of our study was to compare clinical outcome and postoperative complications between patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) treated with and without intraoperative methylprednisolone (MP).Methods: This retrospective study enrolled 101 patients who underwent posterior approach surgery for OLF and were followed up at least 1 year. Patients were divided into two groups according to MP use in the operation: MP group (n=47) and non-MP group (n=54). Clinical outcomes and complications were evaluated before and after operation and at the last follow-up. Results: Significant differences were found in modified Japanese Orthopedics Association (mJOA) scores and proportion of Frankel grade (A-C) between the two groups immediately after surgery and at 2-week follow-up. No significant differences were found between the two groups in mJOA score before operation and at the final follow-up. Moreover, no significant differences were observed in recovery rate according to mJOA score at any time points, and there was no significant difference in the proportion of Frankel grade (A-C) between the two groups at final follow-up. There were 13 documented infections: 10 in the MP group and 3 in the non-MP group (P=0.034).Conclusion: Management therapy with intraoperative 500 mg MP showed better recovery of nerve function within 2 weeks in patients with thoracic myelopathy caused by OLF compared with those did not receive MP. However, long-term follow-up results showed that there was no significant difference in neurological recovery between patients with intraoperative MP or not. Moreover, intraoperative MP increased the rate of wound infection.

scholarly journals New historical data for long-term swordfish ecological studies in the Mediterranean Sea

2021 ◽  
Vol 13 (12) ◽  
pp. 5867-5877
Author(s):  
Brian R. MacKenzie ◽  
Teresa Romeo ◽  
Piero Addis ◽  
Pietro Battaglia ◽  
Pierpaolo Consoli ◽  
...  
Keyword(s):  
Mediterranean Sea ◽  
Fishery Management ◽  
Data Availability ◽  
Knowledge Based ◽  
Time Period ◽  
Before And After ◽  
Trap Fishery ◽  
History Of ◽  
The Mediterranean

Abstract. Management of marine fisheries and ecosystems is constrained by knowledge based on datasets with limited temporal coverage. Many populations and ecosystems were perturbed long before scientific investigations began. This situation is particularly acute for the largest and commercially most valuable species. We hypothesized that historical trap fishery records for bluefin tuna (Thunnus thynnus Linnaeus, 1758) could contain catch data and information for other, bycatch species, such as swordfish (Xiphias gladius Linnaeus, 1758). This species has a long history of exploitation and is presently overexploited, yet indicators of its status (biomass) used in fishery management only start in 1950. Here we examine historical fishery records and logbooks from some of these traps and recovered ca. 110 years of bycatch data (1896–2010). These previously neglected, but now recovered, data include catch dates and amounts in numbers and/or weights (including individual weights) for the time period before and after major expansion of swordfish fisheries in the Mediterranean Sea. New historical datasets such as these could help understand how human activities and natural variability interact to affect the long-term dynamics of this species. The datasets are online and available with open access via three DOIs, as described in the “Data availability” section of the article.

scholarly journals Intracellular detection and communication of a wireless chip in cell

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mimi X. Yang ◽  
Xiaolin Hu ◽  
Demir Akin ◽  
Ada Poon ◽  
H.-S Philip Wong
Keyword(s):  
Personalized Medicine ◽  
Radio Frequency Identification ◽  
Electronic Device ◽  
Power Delivery ◽  
Sensors And Actuators ◽  
Advanced Technique ◽  
Before And After ◽  
A Cell ◽  
Biological Environment

AbstractThe rapid growth and development of technology has had significant implications for healthcare, personalized medicine, and our understanding of biology. In this work, we leverage the miniaturization of electronics to realize the first demonstration of wireless detection and communication of an electronic device inside a cell. This is a significant forward step towards a vision of non-invasive, intracellular wireless platforms for single-cell analyses. We demonstrate that a 25 $$\upmu $$ μ m wireless radio frequency identification (RFID) device can not only be taken up by a mammalian cell but can also be detected and specifically identified externally while located intracellularly. The S-parameters and power delivery efficiency of the electronic communication system is quantified before and after immersion in a biological environment; the results show distinct electrical responses for different RFID tags, allowing for classification of cells by examining the electrical output noninvasively. This versatile platform can be adapted for realization of a broad modality of sensors and actuators. This work precedes and facilitates the development of long-term intracellular real-time measurement systems for personalized medicine and furthering our understanding of intrinsic biological behaviors. It helps provide an advanced technique to better assess the long-term evolution of cellular physiology as a result of drug and disease stimuli in a way that is not feasible using current methods.

scholarly journals New historical data for long-term swordfish ecological studies in the Mediterranean Sea

2021 ◽  
Author(s):  
Brian R. MacKenzie ◽  
Teresa Romeo ◽  
Piero Addis ◽  
Pietro Battaglia ◽  
Pierpaolo Consoli ◽  
...  
Keyword(s):  
Mediterranean Sea ◽  
Fishery Management ◽  
Scientific Investigations ◽  
Knowledge Based ◽  
Time Period ◽  
Before And After ◽  
Trap Fishery ◽  
History Of ◽  
The Mediterranean

Abstract. Management of marine fisheries and ecosystems is constrained by knowledge based on datasets with limited temporal coverage. Many populations and ecosystems have been perturbed long before scientific investigations have begun. This situation is particularly acute for the largest and commercially most valuable species. We hypothesized that historical trap fishery records for bluefin tuna, Thunnus thynnus, could contain catch data and information for other, bycatch species, such as swordfish, Xiphias gladius. This species has a long history of exploitation and is presently overexploited, yet indicators of its status (biomass) used in fishery management only start in 1950. Here we examine historical fishery records and logbooks from some of these traps and recovered ca. 110 years of bycatch data (1896–2010). These previously-neglected, but now recovered, data include catch dates and amounts in numbers and/or weights (including individual weights) for the time period before and after major expansion of swordfish fisheries in the Mediterranean Sea. New historical datasets such as these could help understand how human activities and natural variability interact to affect long-term dynamics of this species.

Do Vaccinated People Reduce Their Precautionary Behaviours? A Test on a British Cohort

2021 ◽  
Author(s):  
Olivier Desrichard ◽  
Lisa Moussaoui ◽  
Nana Ofosu
Keyword(s):  
Vaccination Status ◽  
Drop Out ◽  
Before And After ◽  
History Of ◽  
Massive Change

Abstract Background.There is a risk that people vaccinated against COVID-19 will drop out or reduce their behaviours (i.e. a phenomenon of risk homeostasis). Our aim is to assess the occurrence of this effect in a cohort of UK participants who were interviewed 141 days before and 161 days after the start of the vaccination programme.Methods.Of the 7651 people who could be followed up before and after the start of the programme and whose vaccination status was known, 178 had not received any injection and 583 were more or less advanced in the process (one vs. two doses since less vs. more than 14 days). The frequency of 14 precautionary behaviours was assessed at both times of measurement, as well as potential covariates (gender, age, comorbidities and history of COVID-19).Findings.Controlling for covariates, we found no decrease in precautionary behaviours, including among vaccinated individuals, regardless of how far along they were in the process.Interpretation.The results observed in this sample show that a massive change in behaviour among vaccinated individuals does not threaten the fight against the COVID-19 pandemic. The pressure to adopt precautionary behaviours remains strong and probably prevents the emergence of a risk homeostasis effect. Nevertheless, communication on the importance of precautionary behaviour should be maintained so that it does not regress in the long term.

Sign in / Sign up

Export Citation Format

Share Document