Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model

2007 ◽  
Vol 80 (special_issue_1) ◽  
pp. S49-S55 ◽  
Author(s):  
M Mouiseddine ◽  
S François ◽  
A Semont ◽  
A Sache ◽  
B Allenet ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Severe Combined Immunodeficiency ◽  
Human Mesenchymal Stem Cells ◽  
Combined Immunodeficiency

scholarly journals Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia

2013 ◽  
Vol 8 (3) ◽  
pp. 283-293 ◽  
Author(s):  
Eun Ju Lee ◽  
Hwan-Woo Park ◽  
Hyo-Jin Jeon ◽  
Hyo-Soo Kim ◽  
Mi-Sook Chang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Human Mesenchymal Stem Cells ◽  
Therapeutic Angiogenesis ◽  
Hindlimb Ischemia

scholarly journals Human Mesenchymal Stem Cells Resolve Airway Inflammation, Hyperreactivity, and Histopathology in a Mouse Model of Occupational Asthma

2014 ◽  
Vol 23 (19) ◽  
pp. 2352-2363 ◽  
Author(s):  
Itziar Martínez-González ◽  
Maria-Jesús Cruz ◽  
Rafael Moreno ◽  
Ferran Morell ◽  
Xavier Muñoz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Airway Inflammation ◽  
Occupational Asthma ◽  
Human Mesenchymal Stem Cells

scholarly journals CD271+ Human Mesenchymal Stem Cells Show Antiarrhythmic Effects in a Novel Murine Infarction Model

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1474 ◽  
Author(s):  
Haval Sadraddin ◽  
Ralf Gaebel ◽  
Anna Skorska ◽  
Cornelia Aquilina Lux ◽  
Sarah Sasse ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Ischemia Reperfusion ◽  
Human Mesenchymal Stem Cells ◽  
Antiarrhythmic Effect ◽  
Time Required ◽  
Antiarrhythmic Effects

Background: Ventricular arrhythmias (VA) are a common cause of sudden death after myocardial infarction (MI). Therefore, developing new therapeutic methods for the prevention and treatment of VA is of prime importance. Methods: Human bone marrow derived CD271+ mesenchymal stem cells (MSC) were tested for their antiarrhythmic effect. This was done through the development of a novel mouse model using an immunocompromised Rag2−/− γc−/− mouse strain subjected to myocardial “infarction-reinfarction”. The mice underwent a first ischemia-reperfusion through the left anterior descending (LAD) artery closure for 45 min with a subsequent second permanent LAD ligation after seven days from the first infarct. Results: This mouse model induced various types of VA detected with continuous electrocardiogram (ECG) monitoring via implanted telemetry device. The immediate intramyocardial delivery of CD271+ MSC after the first MI significantly reduced VA induced after the second MI. Conclusions: In addition to the clinical relevance, more closely reflecting patients who suffer from severe ischemic heart disease and related arrhythmias, our new mouse model bearing reinfarction warrants the time required for stem cell engraftment and for the first time enables us to analyze and verify significant antiarrhythmic effects of human CD271+ stem cells in vivo.

Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model

2014 ◽  
Vol 326 (2) ◽  
pp. 230-239 ◽  
Author(s):  
Sandra Winkler ◽  
Erawan Borkham-Kamphorst ◽  
Peggy Stock ◽  
Sandra Brückner ◽  
Matthias Dollinger ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Human Mesenchymal Stem Cells ◽  
Immunodeficient Mouse ◽  
Alcoholic Steatohepatitis
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