scholarly journals The Effect of Cerebrovascular Stenosis on ­Peri-Hematoma Cerebral Perfusion and Clinical Outcomes in Patients with Supratentorial Spontaneous Intracerebral Hemorrhage

2018 ◽  
Vol 24 ◽  
pp. 8647-8654
Author(s):  
Zengpanpan Ye ◽  
Xiaolin Ai ◽  
Jun Zheng ◽  
Lu Ma ◽  
Sen Lin ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Clinical Outcomes ◽  
Cerebral Perfusion ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Cerebrovascular Stenosis

scholarly journals Association Between Alkaline Phosphatase and Clinical Outcomes in Patients With Spontaneous Intracerebral Hemorrhage

2021 ◽  
Vol 12 ◽  
Author(s):  
Sijia Li ◽  
Wenjuan Wang ◽  
Qian Zhang ◽  
Yu Wang ◽  
Anxin Wang ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Logistic Regression ◽  
Intracerebral Hemorrhage ◽  
Clinical Outcomes ◽  
Functional Outcomes ◽  
Adverse Outcomes ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Mortality And Morbidity ◽  
The Third ◽  
Increased Risk

Background: Spontaneous intracerebral hemorrhage (ICH) is associated with high rates of mortality and morbidity. Alkaline phosphatase (ALP) is related to increased risk of cardiovascular events and is also closely associated with adverse outcomes after ischemic or hemorrhagic stroke. However, there are limited data about the effect of ALP on clinical outcomes after ICH. Therefore, we aimed to investigate the relationship between serum ALP level and prognosis in ICH patients.Methods: From January 2014 to September 2016, 939 patients with spontaneous ICH were enrolled in our study from 13 hospitals in Beijing. Patients were categorized into four groups based on the ALP quartiles (Q1, Q2, Q3, Q4). The main outcomes were 30-day, 90-day, and 1-year poor functional outcomes (modified Rankin Scale score of 3–6). Multivariable logistic regression and interaction analyses were performed to evaluate the relationships between ALP and clinical outcomes after ICH.Results: In the logistic regression analysis, compared with the third quartile of ALP, the adjusted odds ratios of the Q1, Q2, and Q4 for 30-day poor functional outcome were 1.31 (0.80–2.15), 1.16 (0.71–1.89), and 2.16 (1.32–3.55). In terms of 90-day and 1-year poor functional outcomes, the risks were significantly higher in the highest quartile of ALP compared with the third quartile after adjusting the confounding factors [90-day: highest quartile OR = 1.86 (1.12–3.10); 1-year: highest quartile OR = 2.26 (1.34–3.80)]. Moreover, there was no significant interaction between ALP and variables like age or sex.Conclusions: High ALP level (>94.8 U/L) was independently associated with 30-day, 90-day, and 1-year poor functional outcomes in ICH patients. Serum ALP might serve as a predictor for poor functional outcomes after ICH onset.

Abstract WP463: Baseline Leukoaraiosis Does Not Modify Clinical Outcomes in Patients With Spontaneous Intracerebral Hemorrhage

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Charoskhon Turabova ◽  
Adeola Olowu ◽  
Chunyan Cai ◽  
Amanda L Jagolino ◽  
Nicole R Gonzales
Keyword(s):  
Intracerebral Hemorrhage ◽  
Clinical Outcomes ◽  
Spontaneous Intracerebral Hemorrhage

scholarly journals The use of neutrophil to lymphocyte ratio as a predictor for clinical outcomes in spontaneous intracerebral hemorrhage

Oncotarget ◽  
2017 ◽  
Vol 8 (52) ◽  
pp. 90380-90389 ◽  
Author(s):  
Zengpanpan Ye ◽  
Xiaolin Ai ◽  
Fang Fang ◽  
Xin Hu ◽  
Andrew Faramand ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Clinical Outcomes ◽  
Neutrophil To Lymphocyte Ratio ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Lymphocyte Ratio

scholarly journals Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women

2021 ◽  
Vol 12 ◽  
Author(s):  
Hao Feng ◽  
Xin Wang ◽  
Wenjuan Wang ◽  
Xingquan Zhao
Keyword(s):  
Logistic Regression ◽  
Intracerebral Hemorrhage ◽  
Clinical Outcomes ◽  
Poor Prognosis ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Lipid Levels ◽  
Multivariate Logistic Regression ◽  
Low Levels ◽  
High Density Cholesterol ◽  
The Relationship

Background: The relationship between serum lipids levels and prognosis after spontaneous intracerebral hemorrhage (ICH) is still unclear. We aim to examine the association between lipid levels and 3-month ICH prognosis in women.Method: We went through a registry of spontaneous ICH cases and selected female patients to study according to our criteria. We collected demographic, clinical, and laboratory information and evaluated serum triglyceride (TG) levels, total cholesterol (TC) levels, low-density cholesterol (LDLC) levels, high-density cholesterol (HDLC) levels, non-high-density cholesterol (non-HDLC) levels, and 3-month modified Rankin Scale (mRS). Multivariate logistic regression was performed, and receiver operating characteristic (ROC) curves were plotted to explore the relationship between serum lipid levels and 3-month ICH clinical outcomes.Results: Two hundred six female patients were included in this study, and 96 (46.6%) of them had poor functional outcomes. In the univariate analysis, low TG (p = 0.006), TC (p = 0.025), LDLC (p = 0.001), non-HDLC (p < 0.001) levels, and high HDL (p = 0.036) levels were associated with poor 3-month clinical outcomes in women. In the multivariate logistic regression, low levels of TG (OR = 0.711, 95% CI = 0.542–0.933, p = 0.014), TC (OR = 0.523, 95% CI = 0.304–0.903, p = 0.020), LDLC (OR = 0.538, 95% CI = 0.307–0.942, p = 0.030), non-HDLC (OR = 0.327, 95% CI = 0.177–0.603, p < 0.001), and a high level of HDLC (OR = 2.075, 95% CI = 1.064–4.047, p = 0.032) with area under the curve (AUC) of 0.610, 0.590, 0.630, 0.645, and 0.415, respectively, remained as independent indicators of poor prognosis at 3 months after adjusting for confounding factors.Conclusion: Low levels of TG, TC, LDLC, non-HDLC, and high levels of HDLC were independently associated with poor prognosis of spontaneous ICH in women.

scholarly journals Stereotactic Catheter Drainage Versus Conventional Craniotomy for Severe Spontaneous Intracerebral Hemorrhage in the Basal Ganglia

2019 ◽  
Vol 28 (8) ◽  
pp. 1025-1032 ◽  
Author(s):  
Jia Shi ◽  
Zhonghai Cai ◽  
Wei Han ◽  
Bo Dong ◽  
Yumin Mao ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Clinical Outcomes ◽  
Operating Time ◽  
Predisposing Factors ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Hematoma Volume ◽  
Good Clinical Outcome ◽  
Catheter Drainage ◽  
Gcs Score

Intracerebral hemorrhage (ICH) is one of the most devastating forms of cerebrovascular pathology. However, its treatment remains a matter of debate among neurosurgeons and neurologists. The study was to explore the efficacy of minimally invasive surgery (stereotactic catheter drainage, SCD) for patients with severe intracerebral hemorrhage (Glasgow Coma Scale, GCS) score ≤ 8 and hematoma volume ≥ 30 cm3) and to determine predisposing factors for good clinical outcome. A total of 75 patients with severe ICH were included in this retrospective study. Patients were assigned to the SCD group (n=38) or the conventional craniotomy group (n=37). Patients were followed up for 12 months postoperatively, and their clinical parameters were compared. During the operation, the SCD group exhibited a lower bleeding volume ( p<0.001) and shorter operating time ( p<0.001) than the conventional craniotomy group. For postoperative efficacy, the rates of pneumonia and tracheotomy were lower ( p=0.002 and p=0.027, respectively), and the duration of hospital and neurosurgery intensive care unit (NSICU) in days were significantly shorter in the SCD group ( p=0.046 and p=0.047, respectively). Furthermore, patients in the SCD group showed improved modified Rankin Scale (mRS) scores at discharge ( p<0.018) and at 12-month follow up ( p<0.001). Predisposing factors for good clinical outcomes were hematoma volume (<50 cm3, 95% confidence interval (CI): 1.043–1.956, p<0.046), initial GCS score (>6, 95% CI: 3.248–187.466, p<0.001), hypertension (none, 95% CI: 1.440–2.922, p<0.001), and treatment modality (SCD, 95% CI: 1.422–3.226, p<0.001). Taken together, SCD surgery is safe and effective in patients with severe ICH and has fewer complications and better clinical outcomes than conventional craniotomy.

Clinical Outcomes and Prognostic Factors for Spontaneous Intracerebral Hemorrhage in Pediatric ICU: A 12-Year Experience

2017 ◽  
Vol 34 (11-12) ◽  
pp. 1003-1009
Author(s):  
Marco Piastra ◽  
Daniele De Luca ◽  
Orazio Genovese ◽  
Federica Tosi ◽  
Francesca Caliandro ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Prognostic Factors ◽  
Intracerebral Hemorrhage ◽  
Clinical Outcomes ◽  
Pediatric Population ◽  
Vegetative State ◽  
Adult Population ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Midline Shift ◽  
Mortality And Morbidity

Background: In the pediatric population, spontaneous intracerebral hemorrhage (sICH) is as common as ischemic stroke and accounts for significant mortality and morbidity. Differently from the ischemic stroke, there are few guidelines for directing management of sICH. This article aims to analyze both clinical outcomes and prognostic factors in order to produce tools for the design of prospective randomized studies addressed to implement treatment of pediatric sICH. Methods: Twelve-year retrospective review of a single-center consecutivesICH pediatric cases admitted to the pediatric intensive care unit (PICU). Selected end points were survival, PICU stay, and dichotomized Glasgow Outcome Score (GOS), with recovery and moderate disability (GOS 4-5) classified as favorable outcome and vegetative state or severe disability (GOS 2-3) classified as unfavorable. Results: Data of 107 children younger than 14 years admitted to our PICU due to sICH were analyzed. Overall PICU mortality was 24.2%. On multivariate analysis, the single factor markedly influencing survival was the presence of midline shift ( P = .002). In PICU survivors, there were 42 GOS 2-3 and 39 GOS 4-5. A low Glasgow Coma Scale (GCS) on PICU admission was predictive of severe neurological impairment in survivors ( P = .003). Intraventricular hemorrhage and infratentorial origin did not influence outcome in this series. Conclusion: The severity of presentation of sICH expressed by the midline shift and the GCS at PICU admission are significant prognostic factors for survival and neurological outcome. Some prognostic factors of the adult population have not been confirmed.

scholarly journals Antihypertensive treatments for spontaneous intracerebral hemorrhage in patients with cerebrovascular stenosis

Medicine ◽  
2017 ◽  
Vol 96 (26) ◽  
pp. e7289 ◽  
Author(s):  
Zengpanpan Ye ◽  
Xiaolin Ai ◽  
Jun Zheng ◽  
Xin Hu ◽  
Sen Lin ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Antihypertensive Treatments ◽  
Cerebrovascular Stenosis

Spontaneous Intracerebral Hemorrhage in the Elderly Population

2018 ◽  
Author(s):  
S. Sommaruga ◽  
R. Beekman ◽  
S. Chu ◽  
Z. King ◽  
C. Matouk ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Elderly Population ◽  
The Elderly ◽  
Spontaneous Intracerebral Hemorrhage
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