scholarly journals Retracted: Antitumor Effects of 8-Deoxylactucin in RB355 Human Retinoblastoma Cells Are Mediated via Apoptosis Induction, Reactive Oxygen Species Production, and Cell Cycle Arrest

2021 ◽  
Vol 27 ◽  
Author(s):  
Tan Guiying ◽  
Li Yue ◽  
Xiong Chao ◽  
Yu Jinhai ◽  
Xu Qihua
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Reactive Oxygen Species Production ◽  
Oxygen Species ◽  
Apoptosis Induction ◽  
Antitumor Effects ◽  
Cycle Arrest ◽  
Retinoblastoma Cells ◽  
Human Retinoblastoma ◽  
Species Production

scholarly journals IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ana Carolina Martínez-Torres ◽  
Alejandra Reyes-Ruiz ◽  
Milena Benítez-Londoño ◽  
Moises Armides Franco-Molina ◽  
Cristina Rodríguez-Padilla
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
Reactive Oxygen Species Production ◽  
Oxygen Species ◽  
Cycle Arrest ◽  
Regulated Cell Death ◽  
Species Production

scholarly journals Antiproliferative and Anti-Invasive Effect of Piceatannol, a Polyphenol Present in Grapes and Wine, against Hepatoma AH109A Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yuichiro Kita ◽  
Yutaka Miura ◽  
Kazumi Yagasaki
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Red Wine ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Apoptosis Induction ◽  
Cycle Arrest ◽  
Invasive Capacity ◽  
Proliferation And Invasion

Piceatannol is a stilbenoid, a metabolite of resveratrol found in red wine. Piceatannol and sera from rats orally given piceatannol were found to dose-dependently suppress both the proliferation and invasion of AH109A hepatoma cells in culture. Its antiproliferative effect was based on cell cycle arrest at lower concentration (25~50 μM) and on apoptosis induction at higher concentration (100 μM). Piceatannol suppressed reactive oxygen species-potentiated invasive capacity by scavenging the intracellular reactive oxygen species. These results suggest that piceatannol, unlike resveratrol, has a potential to suppress the hepatoma proliferation by inducing cell cycle arrest and apoptosis induction. They also suggest that the antioxidative property of piceatannol, like resveratrol, may be involved in its anti-invasive action. Subsequently, piceatannol was found to suppress the growth of solid tumor and metastasis in hepatoma-bearing rats. Thus, piceatannol may be a useful anticancer natural product.

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