scholarly journals Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records

2021 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Simone Yuriko Kameo ◽  
Maria Júlia Oliveira Ramos ◽  
Ricardo Barbosa Lima ◽  
Bruno Ferreira Amorim ◽  
Jéssica Dos Santos Costa ◽  
...  
Keyword(s):  
Weight Loss ◽  
Invasive Ductal Carcinoma ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Exposed Group ◽  
Age Group ◽  
Invasive Ductal Breast Carcinoma ◽  
Cross Sectional ◽  
Breast Invasive Ductal Carcinoma ◽  
Clinical Records

Objective: To evaluate the occurrence of hematological and functional toxicities during chemotherapy with doxorubicin and cyclophosphamide in women with breast invasive ductal carcinoma. Methods: This was a descriptive, cross-sectional and quantitative study, involving the data collection in clinical records of 119 women undergoing chemotherapy for breast invasive ductal carcinoma in an oncology outpatient clinic, carried out between February 2014 and February 2015. Results: The investigated toxicities and their respectively occurrences in patients exposed to doxorubicin and cyclophosphamide were hemoglobinemia (26,5%), leukopenia (21,6%), neutropenia (10,8%), thrombocytopenia (none) and reduced hematocrit (28,4%), in addition to fatigue (93,1%), fever (20,6%), gain (35,3%) and weight loss (22,5%). In these variables, there were no significant differences between the exposed and not exposed patients. The association with taxanes showed a significant reduction in hematocrit values (p=0.019) and the toxicities distributed by age group were not significant within the exposed group. Conclusions: Exposure to doxorubicin and cyclophosphamide was not associated with an increase in the occurrence of hematotoxicities and functional impacts in women with breast ductal invasive carcinoma, except when associated with taxane agents.

scholarly journals Isolated right adrenal metastasis from an invasive ductal breast carcinoma.

2019 ◽  
pp. 10-13
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Invasive Ductal Carcinoma ◽  
Adrenal Glands ◽  
Ductal Carcinoma ◽  
Adrenal Metastasis ◽  
Breast Carcinomas ◽  
Invasive Ductal Breast Carcinoma ◽  
Invasive Breast Carcinomas ◽  
Histopathological Type

Invasive ductal carcinoma (IDC) is the most common histopathological type of breast cancer, accounting for up to 85% of all invasive breast carcinomas [1]. It spreads usually to the bone first. Solitary metastasis is commonly located in the lung, liver or brain [2]. Adrenal glands locations are extremely rare [3]. We report a case of isolated metachronous right adrenal metastasis, diagnosed four years after breast IDC management. The aim is to highlight clinical, diagnostic and therapeutic characteristics of this entity.

scholarly journals Pyridoxine 5′-phosphate oxidase is correlated with human breast invasive ductal carcinoma development

Aging ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 2151-2176 ◽  
Author(s):  
Weimin Ren ◽  
Wencai Guan ◽  
Jinguo Zhang ◽  
Fanchen Wang ◽  
Guoxiong Xu
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Human Breast ◽  
Breast Invasive Ductal Carcinoma

Role of Ag NORs in Improve Diagnosis of Breast Cancer with Different grades and Subtypes’ among Sudanese women

2021 ◽  
Vol 1 (4) ◽  
pp. 443-448
Author(s):  
Doaa Ibrahim Ahmed
Keyword(s):  
Breast Cancer ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Age Group ◽  
Lobular Carcinoma In Situ ◽  
Tissue Sections ◽  
In Situ Carcinoma

This study aimed to evaluate the role of Ag NORs in improves diagnosis of Breast cancer with different subtypes’ among Sudanese Patients. This study include tissue sections of breast cancer diagnosed women, they were 30, ductal and lobular invasive carcinoma were 10 for each, while ductal and lobular in-situ carcinoma were 5 each. Found correlation between subtypes of breast cancer and Ag NOR , Invasive ductal carcinoma had more NOR while the lobular carcinoma in situ was less one , Stage III most frequency than the other stage. Silver staining were performed and Ag-NOR were detected in ductal and lobular invasive carcinoma more than ductal and lobular in-situ carcinoma, grade III has more frequency of Ag-NOR than other stages, and no correlation found between Ag-NOR and age group

scholarly journals Primary Osteosarcoma of the Breast in a Patient Treated Previously for Invasive Ductal Carcinoma: An Unusual Presentation of a Very Rare Primary Breast Malignancy

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
David Malcolm Milne ◽  
Navin Sookar ◽  
Srikanth Umakanthan ◽  
Fidel Rampersad ◽  
Lyronne Olivier ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Osteogenic Sarcoma ◽  
Clinical Entity ◽  
Unusual Presentation ◽  
Rare Clinical Entity ◽  
Ipsilateral Breast ◽  
Breast Malignancy ◽  
Invasive Carcinomas

Primary osteogenic sarcoma of the breast is a rare clinical entity with few cases described in the literature. Unfortunately, the prognosis for these patients is poor when compared to invasive carcinomas of the breast. We report a case of a 58-year-old female who developed a primary osteogenic sarcoma of the breast five years after being treated for invasive carcinoma of the ipsilateral breast without the use of radiotherapy.

scholarly journals Schirrous invasive ductal carcinoma of the breast overexpress p53 oncoprotein

2001 ◽  
Vol 119 (1) ◽  
pp. 04-06 ◽  
Author(s):  
Flávia Silva Ferrini ◽  
Marcos Antonio Rossi ◽  
Mário Mourão Neto ◽  
Fernando Augusto Soares
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Biological Markers ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Progesterone Receptors ◽  
Adult Women ◽  
Estrogen And Progesterone Receptors ◽  
Desmoplastic Reaction ◽  
Ductal Invasive Carcinoma ◽  
The Relationship

CONTEXT: Breast cancer is the most important neoplasm in adult women, and its worldwide incidence is growing. The tumoral stroma is very important for modulating the growth and invasion of the tumor itself. The relationship between these two components is not completely understood. Schirrous carcinoma is a variant of ductal invasive carcinoma in which the stroma is very desmoplastic, and the importance of this finding still a motive for debate in the literature. OBJECTIVE: To compare the desmoplastic reactions against biological markers, such as estrogen and progesterone receptors, oncoprotein c-erbB-2 and oncoprotein p53, with the objective of studying the relationship between the tumoral stroma and epithelial cancer cells. TYPE OF STUDY: Retrospective study. SETTING: Cancer Hospital A C Camargo and Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. SAMPLE: 107 adult women operated because of ductal invasive carcinoma. The cases were separated into 4 groups according to the desmoplastic reaction -- less than 15%, between 15-50%, 51-85%, and more than 85% fibrosis. The grade of fibrosis was determined by picrus-sirius staining and quantified by using a microscope with a stereo-imaging grid. Immunohistochemical methods were used to determine the expression of the hormonal receptors and c-erbB-2/p53 oncoprotein. MAIN MEASUREMENTS: Extent of desmoplastic reaction versus expression of estrogen and progesterone receptors, oncoprotein c-erbB-2, and oncoprotein p53. RESULTS: The results showed that schirrous carcinoma expresses oncoprotein p53 more frequently than other carcinomas with less extensive desmoplastic reaction. There were no differences between the grade of fibrosis and the other biological markers. CONCLUSION: The intense stromatous reaction in invasive ductal carcinoma may modulate the expression of p53. Further investigations should be made with the aim of understanding how this expression determines the proliferative activity in schirrous carcinoma, and whether this overexpression is secondary to mutation of the p53 gene or due to modulation of other molecules of the stroma.

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