Diabetes does not have a negative effect on Quality of Life in the long-term after Limb salvage with Infrageniculate Bypasses accompanied with minor amputations

Patients with psoriasis may experience impaired psychosocial mental status regardless of their objectively defined disease severity. The objective clinical measures of disease that are commonly used to evaluate a patient's psoriasis fail to take into account the effect of psoriasis on patients' quality of life (QOL). As a result, a significant number of patients are dissatisfied with conventional treatments and are searching for new options. A high unmet need for effective and safe long-term therapies that can also improve patients' QOL exists in psoriasis. Alefacept, a selective biologic agent specifically designed for the treatment of psoriasis, provides improvement in both the physical (as measured by the Psoriasis Area and Severity Index) and mental (as measured by the Dermatology Life Quality Index) aspects of the disease. Additionally, alefacept is extremely well tolerated, with no negative effect on QOL, and the improvement in QOL is maintained off-treatment, which is consistent with its remittive effects on the disease. Alefacept helps fulfill the needs of psoriasis patients by providing efficacy, safety, off-treatment remissions, and improvement in QOL.

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Limb Salvage and Amputation in Survivors of Pediatric Lower-Extremity Bone Tumors: What Are the Long-Term Implications?

Journal of Clinical Oncology ◽

10.1200/jco.2002.09.006 ◽

2002 ◽

Vol 20 (22) ◽

pp. 4493-4501 ◽

Cited By ~ 103

Author(s):

Rajaram Nagarajan ◽

Joseph P. Neglia ◽

Denis R. Clohisy ◽

Leslie L. Robison

Keyword(s):

Quality Of Life ◽

Lower Extremity ◽

Limb Salvage ◽

Lower Limb ◽

Bone Tumors ◽

Pediatric Patients ◽

Population Based ◽

Surgical Approaches

ABSTRACT: The past four decades have seen tremendous progress in the treatment of pediatric and adolescent cancers. As a consequence, there are increasing numbers of adult childhood cancer survivors. This has prompted investigation into the long-term consequences of cancer treatments. One group that merits special study is the survivors of lower-extremity bone tumors. Their function and quality of life may depend in part on both the surgery and the age at which it was performed. Comparisons between studies are difficult because small numbers of patients and the use of varying research designs and methods have limited research in this area. The purpose of this article is to review the major surgical approaches to lower-limb bone tumors and their impact on pediatric patients. The results show that survival is equivalent between amputation and limb salvage. Complications occur more frequently in limb salvage. The long-term outcomes of those undergoing amputation and limb salvage have not been found to be substantially different in regard to quality of life. In conclusion, prospective long-term follow-up of pediatric patients with lower-limb tumors is needed to (1) determine in a uniform manner the long-term complications, quality of life, and functionality of this population and describe differences within this patient population based on age at diagnosis and surgical procedure, (2) identify areas of concern that are amenable to intervention, and (3) provide clinicians and future patients a better understanding of the surgical options.

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"Living in Hell": Experiences of Iranian Families Living with Patients with Schizophrenia

10.21203/rs.3.rs-644478/v1 ◽

2021 ◽

Author(s):

Parviz Molavi ◽

Saeid Sadeghieh-Ahary ◽

Mohsen Rezaeian ◽

Elmira Taghizadeh ◽

Elhameh Nasiri ◽

...

Keyword(s):

Quality Of Life ◽

Qualitative Content Analysis ◽

Poor Quality ◽

Main Category ◽

Negative Effect ◽

Need For Support ◽

Tremendous Impact ◽

Sense Of Shame

Abstract Background: In addition to bearing on the patients and public, schizophrenia has a tremendous impact on families and caregivers. Its negative consequence has been studied as a burden. In this study, by doing qualitative analysis, we examined the experiences of Iranian families within the Ardabil, Iran, living with patients with schizophrenia. Method: This research was a qualitative study, and data collection was done through an in-depth, unstructured interview. Twenty family members of patients with schizophrenia were interviewed, and data were analyzed by the conventional qualitative content analysis. Results: The major themes of the interviews were classified into 3-level codes. Six subthemes were found in the experiences of patients with schizophrenia families, namely stigma, sense of shame, isolation, need for support, and lack of awareness, and poor quality of life, which were combined and classified into one main category named "living in hell".Conclusions: The findings showed that schizophrenia has an impressive negative effect on the families' welfare; thus, it highlights the necessity to provide interventions to help them adapt to this disorder. The results also highlight that caring is more demanding for families of long-term disease patients.

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Thinking Beyond Language: Intervention for Severe Aphasia

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld19.1.15 ◽

2009 ◽

Vol 19 (1) ◽

pp. 15-22 ◽

Cited By ~ 3

Author(s):

Nina Simmons-Mackie

Keyword(s):

Quality Of Life ◽

Communication Training ◽

Language Intervention ◽

Specific Training ◽

Environmental Support ◽

Total Communication ◽

Communication Partners

Abstract Purpose: This article addresses several intervention approaches that aim to improve life for individuals with severe aphasia. Because severe aphasia significantly compromises language, often for the long term, recommended approaches focus on additional domains that affect quality of life. Treatments are discussed that involve increasing participation in personally relevant life situations, enhancing environmental support for communication and participation, and improving communicative confidence. Methods: Interventions that have been suggested in the aphasia literature as particularly appropriate for people with severe aphasia include training in total communication, training of communication partners, and activity specific training. Conclusion: Several intervention approaches can be implemented to enhance life with severe aphasia.

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