scholarly journals Influence of ferritin levels and inflammatory markers on HbA1c in the Type 2 Diabetes mellitus patients

2019 ◽  
Vol 35 (4) ◽  
Author(s):  
Nazan Erenoglu Son
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Serum Ferritin ◽  
Inflammatory Markers ◽  
Outpatient Clinics ◽  
Type 2 Dm ◽  
Hba1c Levels

Objective: Diabetes Mellitus (DM) is a significant public health issue worldwide due to the associated comorbidities. Recent studies have demonstrated a strong relationship between blood glucose levels and serum ferritin levels in patients with type 2 DM. The aim of the study was to investigate the association between Ferritin Levels and Inflammatory Markers on HbA1c in the Type 2 Diabetes Mellitus Patients. Methods: This single-center, cross-sectional, controlled study included patients who were admitted to the Endocrine and Metabolic Disorders outpatient clinics of the Private Kütahya Hospital in the province of Kutahya in the Western Turkey. The study included a total of 172 patients, 84 of whom had type 2 DM and 88 without diabetes and constituted the control group. A total of 190 patients with DM were admitted to the Adult Endocrine and Metabolic Diseases Outpatient Clinics of the hospital between July 1, 2018 and September 1, 2018, and among these, the study was conducted on 172 volunteer patients who met the study inclusion criteria and who did not have any missing data. The HbA1c levels, serum ferritin, hemoglobin (Hb), insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), C-Reactive Protein (CRP), lipid profiles, and uric acid levels were compared between the groups. Results: The serum ferritin levels of the patients with type 2 DM significantly increased with increasing HbA1c levels (p<0.01). A strong positive correlation was found between serum ferritin levels and HbA1c and fasting blood glucose (FBG) levels (p<0.01). Conclusions: Our study results show a significant relationship between HbA1c levels and serum ferritin and CRP levels, suggesting that serum ferritin and CRP levels can be used as a routine screening tool for the early diagnosis of DM. However, further large-scale, prospective studies are needed to confirm these findings. doi: https://doi.org/10.12669/pjms.35.4.1003 How to cite this:Son NE. Influence of ferritin levels and inflammatory markers on HbA1c in the Type 2 Diabetes mellitus patients. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.1003 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Correlation Between Lipid Profile with Type 2 Diabetes Mellitus Progression

2020 ◽  
Vol 8 (2) ◽  
pp. 66-72
Author(s):  
Angiesta Pinakesty ◽  
Restu Noor Azizah
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Lipid Profile ◽  
Cholesterol Levels ◽  
Type 2 Dm ◽  
Hba1c Levels

Introduction: Diabetes mellitus (DM) is a non-communicable disease that has increased from year to year. Type 2 diabetes mellitus is not caused by lack of insulin secretion, but is caused by the failure of the body's cells to respond to the hormone insulin (insulin resistance). Insulin resistance was found to be a major contributor to atherogenic dyslipidemia. Dyslipidemia in DM risks 2 to 4 times higher than non-DM. Although dyslipidemia has a great risk for people with type 2 diabetes mellitus, this conventional risk factor only explains a portion (25%) of excess cardiovascular risk in type 2 DM. Discussion: In uncontrolled type 2 DM patients, LDL oxidation occurs faster which results from an increase in chronic blood glucose levels. Glycemic control as a determinant of DM progressivity is determined through HbA1c examination. HbA1c levels are associated with blood triglyceride levels. Meanwhile, triglyceride levels are associated with total cholesterol and HDL cholesterol levels. HbA1c levels are also associated with LDL cholesterol levels. Conclusion: There is a relationship between lipid profile and the progression of type 2 diabetes mellitus.   Keywords: type 2 diabetes mellitus, dyslipidemia, HbA1c, glycemic control, lipid profile

scholarly journals The Effects of Tai Chi on Type 2 Diabetes Mellitus: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Mengyao Chao ◽  
Chunyan Wang ◽  
Xiaosheng Dong ◽  
Meng Ding
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Tai Chi ◽  
Meta Analysis ◽  
Postprandial Blood Glucose ◽  
Type 2 Dm ◽  
Significant Difference

Objective. To investigate the effects of Tai chi in type 2 diabetes mellitus (type-2 DM) patients using systematic review and meta-analysis. Methods. Seven electronic resource databases were searched, and randomized controlled trials on the role of Tai chi in type-2 DM patients were retrieved. The meta-analysis was performed with RevMan 5.3, and research quality evaluation was conducted with the modified Jadad scale. Results. Fourteen studies, with 798 individuals related to the intervention of Tai chi on diabetes, were included. The results showed that, compared with nonexercise, Tai chi had the effect of lowering fasting blood glucose [MD = −1.39, 95% CI (−1.95, −0.84), P<0.0001] and the subgroup effect size decreased with the increase of total exercise amount, there is no significant difference between Tai chi and other aerobic exercises [MD = −0.50, 95% CI (−1.02, 0.02), P=0.06]; compared with nonexercise, Tai chi could reduce HbA1c [MD = −0.21, 95% CI (−0.61, 0.19), P=0.31], and the group effect size decreased with the increase of total exercise amount. The reducing HbA1c effect of Tai chi was better than that of other aerobic exercises, but the difference was at the margin of statistical significance [MD = −0.19, 95% CI (−0.37, 0.00), P=0.05]; compared with nonexercise, Tai chi had the effect of reducing 2 h postprandial blood glucose [MD = −2.07, 95% CI (−2.89, −1.26), P=0.0002], there is no significant difference between Tai chi and other aerobic exercises in reducing 2 h postprandial blood glucose [MD = −0.44, 95% CI (−1.42, 0.54), P=0.38]. Conclusion. Tai chi can effectively affect the management of blood glucose and HbA1c in type-2 DM patients. Long-term adherence to Tai chi has a better role in reducing blood glucose and HbA1c levels in type 2 DM patients.

scholarly journals Are Patients with Type 2 Diabetes Mellitus at a University Hospital in Jeddah Achieving Treatment Goals?

2016 ◽  
Vol 6 (2) ◽  
pp. 35-41
Author(s):  
Suhaib A. Radi ◽  
Nada K. Bashnini ◽  
Hebah Y. Alahwal ◽  
Deemah A. Tashkandi ◽  
Maram J. Sibyani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
Outpatient Clinics ◽  
Treatment Goals ◽  
Hba1c Levels

Background: Diabetes mellitus is one of the most prevalent chronic diseases worldwide and is very debilitating. Studies have shown that adherence to treatment recommendations are rewarded with a decrease in diabetes mellitus - related morbidity and mortality. The aim of this study is to assess adherence to the American Diabetes Association treatment goals in patients with type 2 diabetes mellitus. Methods: This was a retrospective chart review study, between February and April, 2013, of patients with type 2 diabetes mellitus who attended outpatient clinics at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. We included patients provided they were adults (≥ 18 years) with type 2 diabetes mellitus who were regularly followed up at the outpatient clinics, and they have had the disease for more than one year. Results: We included 201 patients between 27 – 96 years old. Most patients had their blood pressure and creatinine levels measured during each visit, and close to half had their HbA1c levels measured twice in the last year of follow up. Approximately 55.10% of the patients achieved an LDL level < 2.6 mmol/L. A relatively small proportion of the patients had blood pressure measurements and HbA1c levels within the recommended guidelines (29.03% and 24.53%, respectively). Conclusion: Diabetes mellitus is not very well controlled. This could be attributed to physicians’ factors and patients’ factors. Further studies to assess this issue are recommended.  

scholarly journals Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Ganesh N. Dakhale ◽  
Harshal V. Chaudhari ◽  
Meena Shrivastava
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Ascorbic Acid ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Vitamin C ◽  
Glycosylated Hemoglobin ◽  
Double Blind ◽  
Type 2 Dm

No study has ever examined the effect of vitamin C with metformin on fasting (FBS) and postmeal blood glucose (PMBG) as well as glycosylated hemoglobin (HbA1c) in the treatment of type 2 diabetes mellitus (DM). The goal was to examine the effect of oral vitamin C with metformin on FBS, PMBG, HbA1c, and plasma ascorbic acid level (PAA) with type 2 DM. Seventy patients with type 2 DM participated in a prospective, double-blind, placebo-controlled, 12-week study. The patients with type 2 DM were divided randomly into placebo and vitamin C group of 35 each. Both groups received the treatment for twelve weeks. Decreased PAA levels were found in patients with type 2 diabetes mellitus. This level was reversed significantly after treatment with vitamin C along with metformin compared to placebo with metformin. FBS, PMBG, and HbA1c levels showed significant improvement after 12 weeks of treatment with vitamin C. In conclusion, oral supplementation of vitamin C with metformin reverses ascorbic acid levels, reduces FBS, PMBG, and improves HbA1c. Hence, both the drugs in combination may be used in the treatment of type 2 DM to maintain good glycemic control.

scholarly journals The Correlation between the levels of HbA1c with Ureum and Creatinine in Patient with Type 2 Diabetes Mellitus

2019 ◽  
Vol 7 (5) ◽  
Author(s):  
Tri Prasetyorini ◽  
Karningsih Sudiro ◽  
Bagya Mujianto ◽  
Rus Martini
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Kidney Failure ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Type 2 Dm ◽  
Hba1c Levels

Introduction and Aims : Untransmitted diseases is the leading cause of death globally. Diabetes mellitus is one of the four priorities of untransmitted diseases. This disease is a chronic disease characterized by blood glucose levels that exceed normal values. High blood sugar levels (hyperglycemia) will cause various complications, one of which is chronic complications that can attack various organs such as eyes, kidneys, nerves and blood vessels. This study aims to find out the correlation between the results of the examination of HbA1c, urea and creatinine levels which is an indicator of complications of Chronic Kidney Failure in Type 2 DM patients. Methods : This research is a survey research using cross-sectional study design. The respondents in this study are Type 2 DM patients who filled out the questionnaire and examined levels of HbA1c, ureum, and creatinine. Analysis of the data performed by using the SPEARMEN test SPSS for Windows 17. Result : The result of the SPEARMEN analysis is p = 0,016 (p < 0.05) which means there is a relationship between the levels of HbA1c with age of respondent. Meanwhile, p = 0,84 (p>0,05) which means there is no relationship between HbA1c levels of type 2 DM with urea levels of type 2 DM patients. While, there is no relationship between HbA1c levels of type 2 DM with creatinine levels of type 2 DM with p = 0.693 (p > 0,05). Conclusions : There is a correlation between HbA1c levels of type 2 diabetes mellitus with the age of the respondent, but there is no correlation between HbA1c levels of type 2 diabetes mellitus with ureum levels of type 2 diabetes mellitus and there is no correlation between HbA1c levels with Creatinine levels of  type 2 diabetes mellitus patients.

scholarly journals Prosthetic treatment after teeth extractions in patients with type 2 diabetes mellitus

2016 ◽  
Vol 144 (9-10) ◽  
pp. 474-477
Author(s):  
Katarina Radovic ◽  
Kosovka Obradovic-Djuricic ◽  
Aleksandra Cairovic ◽  
Mirko Glisic ◽  
Slobodan Djurisic
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Food Intake ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type 2 Dm ◽  
Chewing Ability

Introduction. Good and well balanced diet provided by adequate mastication is part of therapy in patients with type 2 diabetes mellitus (DM). The critical period presents the time immediately after teeth extractions; hence, immediate denture is a rational therapeutical choice for diabetic patients. The presence of immediate denture and its compression might compromise wound healing process, affect chewing ability, food intake and consequently blood glucose level in type 2 DM patients. Objective. The objective of this study was to compare socket opening diameters (SOD), chewing ability, changes in blood glucose level and food intake in type 2 DM patients with and without maxillary immediate complete denture (MICD) during a three-week wound healing period. Methods. The study comprised 78 type 2 DM partially removable denture wearers (42 candidates for teeth extractions and 36 candidates for teeth extractions and insertion of MICDs). During the three-week period participants were followed for SOD, chewing ability and changes in blood glucose level and food intake. Results. Patients with MICD showed significantly lower reduction of SOD (seventh, 14th, 21st day) and higher chewing ability (seventh, 14th, 21st day) in comparison to patients without an MICD. Significantly lower number of patients with an MICD had changes in blood glucose level and food intake. Conclusion. Maxillary immediate complete denture presents a good therapeutic choice for type 2 DM patients, as it provides possibility of adequate mastication after teeth extractions and maintenance of nutritional status and blood glucose level.

scholarly journals IGF-1 levels in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Thipani Angela ◽  
◽  
Chrismis Novalinda Ginting ◽  
Linda Chiuman ◽  
Sahna Ferdinand Ginting
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Active Form ◽  
Type 2 Dm ◽  
The Difference ◽  
Group 2 ◽  
Group 1

Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disorder group with mechanisms that include hyperglycemia, insulin resistance and hyperinsulinemia. Type 2 DM has a close association with IGF-1, where the active form of the IGF-1 becomes elevated by reason of the fact that hyperinsulinemia inhibits the production of IGF-binding proteins (IGFBP) 1/IGFBP 2. The active form of IGF-1 has the ability to promote cell proliferation and inhibit apoptosis, hence becomes one of the risk factors for cancer cell growth. This was an analytical study conducted in August at the Harapan Bunda Clinic, Medan, Indonesia to determine the difference between the IGF-1 level and blood glucose level in type 2 DM patients in different age groups. Twenty subjects with Type 2 DM participated in this study and were divided based on their age into 35-50 years old or Group 1 and 51-65 year old group or Group 2. The IGF-1 levels in both groups were compared and analyzed using the T-test dependent method. Results showed that the IGF-1 and blood glucose levels were higher in Group 1 (35-50 years old) when compared to Group 2 and the difference was significant. The change in the IGF-1 level in diabetic patients cannot be determined only by the blood sugar level.

scholarly journals Analysis of prevalence and prognosis of type 2 diabetes mellitus in patients with acute exacerbation of COPD

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Lin ◽  
Jianxin Shi ◽  
Jian Kang ◽  
Qiuyue Wang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Acute Exacerbation ◽  
Acute Exacerbation Of Copd ◽  
Type 2 Dm ◽  
Hospital Stays ◽  
Exacerbation Of Copd

Abstract Background For patients with acute exacerbation of COPD (AECOPD), type 2 diabetes mellitus (T2DM) as comorbidity have poor outcomes. However, data on the impact of previously diagnosed and new- diagnosed T2DM in such a patient population is lacking. Methods Inpatients diagnosed with AECOPD in the department of Pulmonary and Critical Care Medicine of The First Hospital of China Medical University during 2011–2017 were enrolled. Data on demography, prevalence of type 2 DM, other comorbidities, hospital stays and laboratory tests (including arterial partial pressure of oxygen [PaO2]) results were recorded. Results were compared with AECOPD patients having previously diagnosed and new-diagnosed type 2 diabetes. Markers associated with development of type 2 DM and the prognosis of AECOPD patients were identified. Results Of the 196 patients enrolled in this study, the overall prevalence of T2DM was 26%. The PaO2 in the newly diagnosed T2DM group was considerably lower versus non-diabetic group. The T2DM group had a longer hospital stay and higher troponin level versus the non-diabetic group. AECOPD patients with T2DM were found to be correlated with hypertension. Age, need for assisted ventilation, increased troponin, and elevated fasting blood glucose on admission were risk factors for death in hospitalized AECOPD patients. Conclusions AECOPD patients had a higher prevalence of T2DM than the general population; T2DM comorbidity caused lower PaO2, longer hospital stays, and increased troponin. Poor blood glucose control may increase the risk of death in AECOPD patients.

scholarly journals HbA1c –Marker for Long Term Glycemic Control

2020 ◽  
Vol 9 (1) ◽  
pp. BC01-BC03
Author(s):  
Ajay Puri ◽  
Jyoti Kohli ◽  
V.J. Chrunjoo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Protein Glycation ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Hba1c Levels

Background: Protein glycation is a spontaneous reaction that is believed to play a key role in the pathogenesis of many clinical disorders. The glycation of proteins is enhanced by elevated blood glucose concentrations. The major form of protein glycation with a clinical consideration is glycatedhaemoglobin (HbA1c). HbA1c is majorly affected by the blood glucose levels alone. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Studies have suggested that HbA1c levels in type-2 diabetes mellitus patients mostly remains elevated, yet some such patients, with or without tight glycemic control, have HbA1c levels nearly close to or within the normal reference range.Subjects and Methods:In this study HbA1c, fasting blood glucose levels and post prandial blood glucose levels in normal subjects as well as in patients with Type-2 diabetes mellitus excluding the complicated ones were studied.Results:The present study confirms earlier studies that all these levels are tightly correlated and the corresponding p values were < 0.001 which were significant and was estimated by using student t-test.Conclusion: Thus indicating that glycated hemoglobin (HbA1c) can be used to assess the glycemic status of an individual for attaining the treatment goal of preventing long term complications of diabetes mellitus.

scholarly journals Factors predicting the progression of diabetic kidney disease in type 2 diabetic patients using continuous glucose monitoring

2021 ◽  
Vol 17 (7) ◽  
pp. 552-556
Author(s):  
K.I. Moshenets ◽  
N.O. Pertseva
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Regression Analysis ◽  
Blood Glucose ◽  
Kidney Disease ◽  
Blood Glucose Level ◽  
Diabetic Kidney Disease ◽  
Type 2 Dm

Background. An increase in the prevalence of type 2 diabetes mellitus (DM) is accompanied by an increase in the number of patients with severe chronic complications. Diabetic kidney disease (DKD) is the leading cause of death in these patients after cardiovascular diseases. The purpose was to predict the progression of DKD in patients with type 2 diabetes mellitus depending on the glucose variability (GV) measured by continuous glucose monito­ring. Materials and methods. We examined 53 type 2 DM patients aged 57.0 (51.0; 64.0) years with an average disease duration of 9.0 (6.0; 13.0) years. The laboratory examination included determination of glycated hemoglobin, blood creatinine, albuminuria (AU), glomerular filtration rate (GFR) according to CKD-EPI equation. GV was measured by iPro2 GMS system. The maximum and minimum blood glucose levels and standard deviation (SD) of glycemia were considered. The role of GV in predicting DKD progression has been established using stepwise multiple regression analysis. Results. DKD was detected in 41.51 % of patients. In regression analysis, we created a linear multiple regression equation to describe the dependence of AU on the GV, F = 10.39 (p < 0.001). The variability of AU by 36.7 % is due to the minimum level of glycemia and SD of glycemia — multiple correlation coefficient R is 0.6372, the coefficient of determination R2 is 0.4060, adjusted R2 is 0.3670. Partial coefficient of correlation between AU and SD of glycemia, r = 0.25 (p = 0.027); between AU and the minimum blood glucose level, r = 0.31 (p = 0.005). Conclusions. According to the results of correlation analysis, a significant effect of GV, as well as the value of minimum blood glucose level on AU was established. It is statistically proved that high fluctuations of glycemia (SD) should be considered as a factor predicting the progression of DKD in type 2 DM patients. Using regression analysis, a mathematical model of DKD progression in type 2 DM patients was developed based on GV parameters.

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