scholarly journals Comparison of hs-CRP level between low calorie high protein to standard protein diet in obese individuals with weight cycling - a randomised trial

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 447
Author(s):  
Adventia Natali Paranoan ◽  
Joan Jutamulia ◽  
Septian Ika Prasetya ◽  
Ninik Mudjihartini ◽  
Fiastuti Witjaksono
Keyword(s):  
Caloric Intake ◽  
High Protein ◽  
Weight Cycling ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Daily Caloric Intake ◽  
Calorie Diet ◽  
Healthy Obese ◽  
Hs Crp ◽  
Standard Protein

Background: Obesity is associated with various health problems. Low-grade inflammation is a condition found in obese people and contributes to the development of various diseases. The objective of this study was to compare the effects of calorie restriction diet with high-protein (HP) or standard protein (SP) to inflammation marker (hs-CRP) in obese individuals with weight cycling. Methods: 61 healthy obese men and women (25 – 49 years old) with a history of weight cycling were recruited and were randomly assigned to one of the intervention groups, HP or SP groups. Both groups were suggested to reduce their daily caloric intake by 1000 kcal with regular physical activity for 56 days. Subjects in HP group were given a daily protein intake of 22-30% from total daily caloric intake, while SP group were prescribed 12-20%. Dietary consultation was conducted through daily reminder by phone and weekly counseling. The measurement of hs-CRP level was performed prior to and at the end of the intervention. Results: 54 subjects completed the program, yet due to several reasons only 32 of them were measured for hsCRP before and after completing the program, 15 from HP group and 17 from SP group. After completing the 56-day diet program, SP group experienced reduction of hs-CRP by -0.446 + 4.239, while HP underwent increase by 0.135 + 2.389. The mean difference of change in hs-CRP level between the two groups were not statistically significant (P=0.094). Conclusion: Low calorie diet with either HP or SP for 8 weeks significantly reduced body weight (P<0.001) and BMI (P<0.001) in healthy obese subjects but the difference of change in the hs-CRP level between them were not significant. The protein composition of a low calorie diet may not affect the inflammatory state of obese individuals with weight cycling. Trial registration number: NCT03374150

scholarly journals Comparison of plasma malondialdehyde and glutathione levels between low calorie high protein diet to standard protein in obese individuals with weight cycling – a randomised trial

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 446
Author(s):  
Septian Ika Prasetya ◽  
Joan Jutamulia ◽  
Adventia Natali Paranoan ◽  
Fiastuti Witjaksono ◽  
Ninik Mudjihartini
Keyword(s):  
Oxidative Stress ◽  
High Protein ◽  
Weight Cycling ◽  
Obese People ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
The Mean ◽  
Standard Protein ◽  
Plasma Malondialdehyde

Background: Increasing BMI increases the risk of developing cardiovascular and metabolic diseases. Oxidative stress is believed to be the underlying mechanism. A significant proportion of people who have previously succeeded in reducing body weight acquire subsequent weight gain (weight cycling). The current study aimed to evaluate the effects of low calorie diets, either with high or standard protein on plasma malondialdehyde (MDA) and glutathione (GSH) levels in obese people with a history of weight cycling. Methods: A clinical trial was conducted in a worker’s health centre in Jakarta. Participants were assigned to a caloric restriction diet, with two different intervention groups; a high protein/HP group (22-30% of total caloric intake from protein) and a standard protein/SP group (12-20% protein). The diet programme was applied for 8 weeks with daily reminders and weekly counselling. 61 participants were recruited. 54 participants completed the programme but only 15 subjects had their MDA and GSH level measured pre- and post-treatment. Plasma MDA and GSH levels were measured according to Will’s method and Ellman’s method, respectively. Results: The mean changes of MDA levels after completing the diet programme in the HP and SP group were 0.031 + 0.124 and -0.034 + 0.363 nmol/ml plasma, respectively. Meanwhile, the mean changes of GSH levels in the HP and SP group were -0.059 + 0.1673 and -0.034 + 0.363 µg/ml plasma, respectively. No statistical significance were found between the mean difference of plasma MDA and GSH level changes among both groups.  Conclusions: Changes in MDA and GSH levels after high protein or standard protein low-calorie diet intervention for 8 weeks were not significantly different. Protein proportion in the low calorie diet does not affect the change in oxidative stress state for obese individuals with weight cycling. Trial registration number: NCT03374150

scholarly journals Comparison of body composition changes between low calorie high protein diet to standard protein in obese individuals with weight cycling – a randomised trial

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 445 ◽  
Author(s):  
Joan Jutamulia ◽  
Adventia Natali Paranoan ◽  
Septian Ika Prasetya ◽  
Ninik Mudjihartini ◽  
Fiastuti Witjaksono
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Weight Cycling ◽  
Low Calorie ◽  
Protein Group ◽  
History Of ◽  
Standard Protein

Background: The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases. A large proportion of people who had succeeded to reduce body weight failed to maintain it (weight cycling). Studies were inconclusive about the best composition in the diet for such people. The purpose of this research was to evaluate the body composition changes resulted from low calorie high protein and standard protein diet programme in obese people with history of weight cycling. Methods: This is an open-randomized clinical trial of weight loss program as a part of a larger study researching the effect of low calorie high protein diet to body composition, oxidative stress, inflammation marker and metabolic syndrome in obese with weight cycling. A total of 61 adult obese men and women with history of weight cycling were recruited. Subjects were assigned to low calorie diet and were randomly distributed into two intervention groups, namely high protein group (22-30 % of total calories intake) and standard protein group (12-20%). Anthropometry and body composition data were taken at baseline and at the end of the study. Subjects were followed up to 8 weeks with daily reminder and weekly counselling. Results: Fourty five participants completed the study. There were significant reductions in in body weight and body mass index (BMI), fat mass, fat mass percentage, muscle mass, and gain in muscle mass percentage occurred in both groups (Standard protein: P<0.001; High protein: P<0.001 for all variables except for fat mass P= 0,001) with no difference between group (P>0.05). Conclusion: Calories deficit with either high protein or standard protein for 8 weeks brought about significant reduction in body composition

scholarly journals Effects of Vitamin D Supplementation on Omentin-1 and Spexin Levels, Inflammatory Parameters, Lipid Profile, and Anthropometric Indices in Obese and Overweight Adults with Vitamin D Deficiency under Low-Calorie Diet: A Randomized Placebo Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Elhameh Cheshmazar ◽  
Agha Fatemeh Hosseini ◽  
Bahareh Yazdani ◽  
Elham Razmpoosh ◽  
Mitra Zarrati
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Density Lipoprotein ◽  
Vitamin D Supplementation ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Hs Crp

Background and Aims. Improved vitamin D levels can have a favorable effect on some metabolic variables. The objective of the current study was to determine the effects of vitamin D supplementation during a weight-loss intervention on the levels of omentin-1, spexin, lipid profiles, and inflammatory factors in obese and overweight participants. Methods and Materials. In this double-blind placebo-controlled randomized clinical trial, 70 overweight and obese participants with vitamin D deficiency (25(OH)D ≤ 20 nmol/L) were assigned into the intervention (a daily dose of 2,000 IU vitamin D + low-calorie diet) and placebo (placebo + low-calorie diet) groups for 8 weeks. Anthropometric parameters, serum levels of 25-hydroxy vitamin D (25(OH)D), lipid profiles, omentin-1 and spexin levels, high-sensitivity C-reactive protein (hs-CRP), and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations were assessed before and after the intervention. Results. Vitamin D supplementation after the intervention led to a significant decrease in triglycerides (TG) ( P = 0.02 ), very-low-density lipoprotein-cholesterol (VLDL-C) ( P = 0.02 ), and hs-CRP ( P = 0.03 ) concentrations and a significant increase in the serum vitamin D level ( P < 0.001 ). Furthermore, after adjusting for baseline values, age, and baseline BMI, the levels of serum high-density lipoprotein-cholesterol (HDL-C) ( P = 0.01 ) increased significantly, and a significant reduction was observed in the concentration of sICAM-1 ( P = 0.01 ) in the intervention group. However, we did not find any significant difference in serum omentin-1 and spexin concentrations between the groups after intervention. Conclusions. Vitamin D supplementation along with a low-calorie diet (LCD) program for 8 weeks significantly decreased the inflammatory markers in obese individuals, while it did not alter serum omentin-1 and spexin concentrations.

Sign in / Sign up

Export Citation Format

Share Document