scholarly journals Humanistic burden and economic impact of chronic kidney disease: a systematic literature review

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 2142 ◽  
Author(s):  
Caroline Freeman ◽  
Lucia Giles ◽  
Polly Field ◽  
Elisabeth Sörstadius ◽  
Heleen van Haalen
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Resource Use ◽  
Healthcare Costs ◽  
Symptom Burden ◽  
Disease Stage ◽  
Life Questionnaire ◽  
Quality Of Life Questionnaire ◽  
Reported Data

Background: Chronic kidney disease (CKD) is increasing in prevalence worldwide. Progression of CKD to end-stage renal disease (ESRD) can result in the requirement for renal replacement therapy, which incurs considerable healthcare costs and imposes restrictions on patients’ daily living. This systematic review was conducted to inform understanding of the humanistic and economic burden of CKD by collecting quality of life (QoL), symptom burden, and cost and resource use data, with a focus on the impact of disease progression. Methods: Embase, MEDLINE, the Cochrane Library, and conference proceedings were searched in May 2017 according to predefined inclusion criteria. Data were extracted for full publications reporting either QoL or symptom burden (published 2007–2017; reporting data from ≥ 100 patients) or costs and resource use (published 2012–2017). Relevant QoL studies were those that used the 6-dimension or 8-, 12-, or 36-item Short-Form Health Surveys, 5-dimension EuroQol questionnaire, Healthy Days/Health-Related Quality of Life questionnaire, or Kidney Disease Quality of Life Questionnaire. Results: Data were extracted from 95 studies reporting QoL data, 47 studies reporting cost and resource use data, and eight studies reporting descriptions of symptoms; 12 studies (seven QoL; five costs/resource use) reported data for patients with and without CKD, and 15 studies (seven QoL; eight costs/resource use) reported data by disease stage. Patients with CKD, including those with ESRD, had worse QoL than those with normal kidney function, and incurred higher healthcare costs. Disease progression was associated with cost increases, particularly for later stages and in patients receiving dialysis. Increasing CKD severity was also associated with reductions in QoL, although not all studies identified showed a consistent decrease with increasing disease stage. Conclusions: The presence of CKD and CKD progression are associated with reductions in patients’ QoL and increased economic impact. This may be mitigated by interventions that slow progression.

scholarly journals Symptom Burden in Oral Cancer Patients During and Postcancer Treatment

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 113s-113s
Author(s):  
C. Sundaramoorthy ◽  
V. Pooja ◽  
V. Surendran
Keyword(s):  
Quality Of Life ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Symptom Burden ◽  
Demographic Variables ◽  
Disease Stage ◽  
Life Questionnaire ◽  
Oral Cancer Patients ◽  
C 30

Background: Oral cancer is one of the most common cancers seen in India which accounts for about 30% of all type cancers, with ranking as the top most among male. Due to advancements in diagnostic and treatment modalities, the survivorship of oral cancer patients has increased significantly during the last decade. Yet, the treatment of cancer accompanies symptom burden and psychosocial problems that impacts the quality of life of the patients. Aim: To assess the symptom burden among oral cancer patients during and post cancer treatment. Methods: A cross-sectional investigation was conducted to assess the symptom burden of 100 oral cancer patients (age range= 18-65 years, mean age=49.76) from a regional cancer institute (WIA), Chennai, India. Among them, 59 patients were under treatment and 41 had completed the treatment. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and QLQ-H & N 35 module were used. The dependent t-test was used to compare two groups and Spearman correlation coefficients were used to assess the relationship between symptoms and demographic variables. Results: Significant difference was observed in the levels of pain and insomnia on symptoms scale of QLQ-C 30 between patients receiving and completed treatment ( P < 0.05). Similarly, pain score on QLQ-HN 35 differed significantly between the patients on and after treatment ( P < 0.05). In the QLQ-HN 35 module, dry mouth, opening mouth, sticky saliva, pain and tooth problems ranked as most worsening symptoms among oral cancer patients. However, in the QLQ-C 30, financial difficulties, fatigue and pain were ranked as the most worsening symptoms among oral cancer patients. Scores were significantly associated with a number of demographic variables such as age, gender, education, disease stage, time since diagnosis and treatment ( P < 0.05). Conclusion: Oral cancer patients experience numerous worsening symptoms during as well as, posttreatment. This study emphasis the importance of assessing the symptom burden of the patients throughout the course of and completion of treatment as effective management could be implemented.

scholarly journals Depressed mood and poor quality of life in male patients with chronic renal failure undergoing hemodialysis

2010 ◽  
Vol 32 (4) ◽  
pp. 369-374 ◽  
Author(s):  
Thales Weber Garcia ◽  
Joel Paulo Russomano Veiga ◽  
Lucilia Domingues Casulari da Motta ◽  
Flávio José Dutra de Moura ◽  
Luiz Augusto Casulari
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Negative Correlation ◽  
Rating Scale ◽  
Significant Negative Correlation ◽  
Life Questionnaire ◽  
Quality Of Life Questionnaire ◽  
Male Patients ◽  
Hamilton Rating Scale

OBJECTIVE: To assess mood and quality of life in male hemodialysis patients, and to correlate mood swings with the different domains of the quality of life questionnaire. METHOD: Forty-seven male patients undergoing regular hemodialysis for more than six months were included in the study. The Hamilton Rating Scale for Depression and the Kidney Disease Quality of Life Questionnaire, in a version translated into and adapted to Portuguese, were used. RESULTS: The patients' age was 39.4 ± 8.9 years (median ± SD). Depression was observed in 32 (68.1%) patients according to the Hamilton Rating Scale for Depression. A significant negative correlation was found between the results from the Hamilton Rating Scale for Depression and the following parameters of the specific dimensions of the Kidney Disease Quality of Life Questionnaire: list of symptoms and problems (rs = -0.399; p = 0.005), quality of social interaction (rs = -0.433; p = 0.002), and quality of sleep (rs = -0.585; p < 0.001). Among the generic domains, mood showed a significant negative correlation with general health (rs = -0.475; p < 0.001), emotional well-being (rs = -0.354; p = 0.015), social functioning and energy/fatigue (rs = -0.518; p < 0.001). The other parameters of the Kidney Disease Quality of Life Questionnaire did not show significant correlations with the Hamilton Rating Scale for Depression. CONCLUSION: Mood showed a negative correlation with the various scores of quality of life assessed by the Kidney Disease Quality of Life Questionnaire, suggesting a possible influence of mood on the quality of life of chronic renal patients undergoing hemodialysis.

198 Kidney Disease Quality of Life Questionnaire (KDQOL)-36 Items Associated with Anemia Severity

2011 ◽  
Vol 57 (4) ◽  
pp. B66
Author(s):  
Tracy J. Mayne ◽  
Shaowei Wan ◽  
Richard Mutell ◽  
Matthew Gitlin ◽  
David Harrison ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Life Questionnaire ◽  
Quality Of Life Questionnaire

The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study.

1996 ◽  
Vol 14 (10) ◽  
pp. 2756-2768 ◽  
Author(s):  
M A Sprangers ◽  
M Groenvold ◽  
J I Arraras ◽  
J Franklin ◽  
A te Velde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Performance Status ◽  
The United States ◽  
Disease Stage ◽  
Scaling Analysis ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire

PURPOSE To construct a breast cancer-specific quality-of-life questionnaire (QLQ) module to be used in conjunction with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and to test its reliability and validity cross-culturally. PATIENTS AND METHODS Module construction took place after the EORTC guidelines for module development. The module--the QLQ-BR23--consists of 23 items covering symptoms and side effects related to different treatment modalities, body image, sexuality, and future perspective. This module was tested in 170 Dutch, 168 Spanish, and 158 American cancer patients at two points in time. The timing for the Dutch and Spanish patients was before and during treatment with radiotherapy or chemotherapy. For the American patients, the questionnaire was administered at admission at the breast clinic and 3 months after the first assessment. RESULTS Multitrait scaling analysis confirmed the hypothesized structure of four of the five scales. Cronbach's alpha coefficients were, in general, lowest in Spain (range; .46 to .94) and highest in the United States (range; .70 to .91). On the basis of known-groups comparisons, selective scales distinguished clearly between patients differing in disease stage, previous surgery, performance status, and treatment modality, according to expectation. Additionally, selective scales detected change over time as a function of changes in performance status and treatment-induced change. CONCLUSION These results lend support to the clinical and cross-cultural validity of the QLQ-BR23 as a supplementary questionnaire for assessing specific quality-of-life issues relevant to patients with breast cancer.

Alexithyme Patientenmerkmale und Lebensqualität – Eine Querschnittsstudie an 79 ambulanten Patienten mit Angststörungen

2013 ◽  
Vol 61 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Katrin Leenen ◽  
Michael Rufer ◽  
Hanspeter Moergeli ◽  
Hans-Jörgen Grabe ◽  
Josef Jenewein ◽  
...  
Keyword(s):  
Quality Of Life ◽  
World Health ◽  
Life Questionnaire ◽  
World Health Organization Quality ◽  
Fand Sich ◽  
Quality Of Life Questionnaire ◽  
Organization Quality ◽  
Health Organization ◽  
Tas 20

Aus Untersuchungen in der Normalbevölkerung ist bekannt, dass Menschen mit erhöhten Alexithymiewerten eine verminderte Lebensqualität (LQ) aufweisen. Für Patienten mit psychischen Störungen wurde dieser Zusammenhang jedoch kaum untersucht. Ziel dieser Studie war es, den möglichen Zusammenhang zwischen alexithymen Patientenmerkmalen und der LQ bei Patienten mit Angststörungen zu überprüfen. Bei 79 ambulanten Patienten mit Angststörungen wurden alexithyme Charakteristika mit der Toronto Alexithymia Scale (TAS-20), die LQ mit der Kurzversion des World Health Organization Quality of Life Questionnaire 100 (WHOQOL-BREF) erfasst. Darüber hinaus fand eine Erhebung der psychischen Symptombelastung (SCL-90-R) und depressiven Symptomatik (MADRS) statt. Mittels hierarchischer Regressionsanalysen wurde der Zusammenhang zwischen der alexithymen Charakteristika und den unterschiedlichen LQ-Domänen berechnet. Die Patienten zeigten eine im Vergleich zur Normalbevölkerung deutlich verminderte LQ. Als Hauptergebnis fand sich, auch nach Kontrolle von Depression, Ängstlichkeit und Geschlecht, ein signifikanter Zusammenhang zwischen den beiden TAS-20 Subskalen Schwierigkeiten, Gefühle zu identifizieren und zu beschreiben und vor allem der psychischen LQ. Unsere Ergebnisse sprechen dafür, bei der Diagnostik und Therapieplanung von Patienten mit Angststörungen alexithyme Merkmale einzubeziehen. Im Falle von ausgeprägten alexithymen Merkmalen sollten psychotherapeutische Interventionen zur Verbesserung der Schwierigkeiten Gefühle wahrzunehmen und zu kommunizieren in Betracht gezogen werden.

Sign in / Sign up

Export Citation Format

Share Document