scholarly journals Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 393 ◽  
Author(s):  
Kenneth E. Bernstein ◽  
Zakir Khan ◽  
Jorge F. Giani ◽  
Tuantuan Zhao ◽  
Masahiro Eriguchi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Angiotensin Converting Enzyme ◽  
Pressure Control ◽  
Recent Analysis ◽  
Immune Responsiveness ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Myelomonocytic Cells

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

scholarly journals Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response

2014 ◽  
Vol 395 (10) ◽  
pp. 1173-1178 ◽  
Author(s):  
Kenneth E. Bernstein ◽  
Romer A. Gonzalez-Villalobos ◽  
Jorge F. Giani ◽  
Kandarp Shah ◽  
Ellen Bernstein ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Renal Function ◽  
Alzheimer Disease ◽  
Angiotensin Converting Enzyme ◽  
Pressure Control ◽  
Converting Enzyme ◽  
Monocytic Cells ◽  
Effective Immune Response ◽  
Enzyme Overexpression

Abstract Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability of the immune response to defend against a wide variety of antigenic and non-antigenic challenges.

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