scholarly journals Factors that Determine the in vivo Dose-Response Relationship for Stable Chromosome Aberrations in A-Bomb Survivors

1992 ◽  
Vol 33 (SUPPLEMENT) ◽  
pp. 206-214 ◽  
Author(s):  
AKIO A. AWA ◽  
MIMAKO NAKANO ◽  
KAZUO OHTAKI ◽  
YOSHIAKI KODAMA ◽  
JOE LUCAS ◽  
...  
Keyword(s):  
Dose Response ◽  
Chromosome Aberrations ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Oral Artesunate Dose-Response Relationship in Acute Falciparum Malaria

2002 ◽  
Vol 46 (3) ◽  
pp. 778-782 ◽  
Author(s):  
Brian J. Angus ◽  
Itaporn Thaiaporn ◽  
Kenechanh Chanthapadith ◽  
Yupin Suputtamongkol ◽  
Nicholas J. White
Keyword(s):  
Falciparum Malaria ◽  
Dose Response ◽  
Parasite Clearance ◽  
Multidrug Resistant ◽  
Maximum Effect ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
To Receive ◽  
The Relationship

ABSTRACT The combination of an oral artemisinin derivative (usually artesunate) and mefloquine has become standard treatment for multidrug-resistant falciparum malaria in several parts of Southeast Asia. The doses of artesunate used in monotherapy and combination treatment have largely been derived empirically. In order to characterize the in vivo dose-response relationship for artesunate and thus rationalize dosing, 47 adult patients with acute uncomplicated falciparum malaria and parasitemia ≥1% were randomized to receive a single oral dose of artesunate varying between 0 and 250 mg together with a curative dose of oral mefloquine. Acceleration of parasite clearance was used as the pharmacodynamic variable. An inhibitory sigmoidal maximum effect (E max) pharmacodynamic model typical of a dose-response curve was fitted to the relationship between dose and shortening of parasite clearance time (PCT). The E max was estimated as 28.6 oral h, and the 50% effective concentration was 1.6 mg/kg of body weight. These results imply that there is no reduction in PCTs with the use of single doses of artesunate higher than 2 mg/kg, and this therefore reflects the average lower limit of the maximally effective dose.

scholarly journals Critical Evaluation of Two Commercial Biocontrol Agents for Their Efficacy against B. cinerea under In Vitro and In Vivo Conditions in Relation to Different Abiotic Factors

Agronomy ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1868
Author(s):  
Gurkan Tut ◽  
Naresh Magan ◽  
Philp Brain ◽  
Xiangming Xu
Keyword(s):  
Dose Response ◽  
Abiotic Factors ◽  
Critical Evaluation ◽  
Leaf Disc ◽  
Biocontrol Agents ◽  
In Vivo Studies ◽  
Response Relationship ◽  
Dose Response Relationship

The study evaluated the dose–response relationship of two commercial microbial biocontrol agents, Bacillus subtilis and Gliocladium catenulatum, against Botrytis cinerea both in vitro and in vivo. Inoculum doses, formulation, temperature and foliar leaf part all affected the control achieved by the two BCAs. In vitro competition assays on modified PDA plates tested a range of BCA doses (log10 3–10 CFUs or spores/droplet) at 4, 10 and 20 °C on the development of B. cinerea colonies. The dose–response relationship was influenced by both the BCA formulation and temperature. In vivo studies on lettuce plants in semi-commercial greenhouses examined the BCA dose (log10 5–9 CFUs or spores/mL) for controlling B. cinerea with a high inoculum (log10 6 spores/mL). Leaf disc assays showed that the dose–response relationship was influenced by the leaf parts sampled. These results suggest that the dose–response relationship between a BCA and specific pathogen will be significantly influenced by environmental conditions, formulation and plant phyllosplane tissue.

Sign in / Sign up

Export Citation Format

Share Document