Radiation Contribution Assessment to Development of Multiple Oncological Diseases in the Late Period of Acute Radiation Disease

2021 ◽  
Vol 66 (1) ◽  
pp. 44-48
Author(s):  
I. Galstyan ◽  
M. Konchalovsky ◽  
M. Kozlova ◽  
V. Nugis
Keyword(s):  
Radiation Effects ◽  
Acute Radiation ◽  
Malignant Neoplasms ◽  
Early Diagnostics ◽  
Adequate Treatment ◽  
Clinical Observations ◽  
Oncological Diseases ◽  
The Given

Purpose: On clinical examples to estimate a probable contribution of the postponed earlier external radiation of all body in the doses exceeding 1 Gy at development of multiple malignant neoplasms of different localization and a leukaemia. Material and methods: At 8 of 164 patients, it is long observed after the postponed acute radiation syndrome (ARS), multiple oncological diseases are revealed. Dynamics of consecutive forming of solid tumors at 2 patients and also malignant neoplasms and a myelodysplastic syndrome (MDS) with transformation in an acute leukamia at 1 patient is tracked. Observation duration – 31 years, 43 years and 32 years. Results: Availability of medical care to the patients who transferred ARS and high quality of its rendering at all stages (out-patient, stationary) allowed to reveal malignant neoplasms at early stages of development and to achieve an absolute recovery. However eventually at these patients development and other oncological diseases was observed. The given clinical observations allow to assume that at presented cases radiation acted on various stages of carcinogenesis, and its contribution to development of different oncological diseases in all patients was not identical. Conclusion: The analysis of clinical observations allows to assume that radiation contribution to genesis of various oncological diseases at the persons which underwent radiation in the doses causing development of ARS is various. Now in our country there are no approaches to quantitative assessment of a contribution of radiation effects to development of malignant neoplasms in each case. The patients who underwent acute single exposition in doses over 1 Gy have to be considered as having predisposition to development of multiple tumors in the remote terms. In this regard they for life need medical follow up for the purpose of early diagnostics and adequate treatment of the developing malignant neoplasms.

scholarly journals OSTEOPETROSIS AND ENDOPROSTHETICS - CLINICAL OBSERVATIONS

2017 ◽  
Vol 2 (4) ◽  
pp. 65-72
Author(s):  
NS S Nikolaev ◽  
LV V Borisova ◽  
SN N Didichenko ◽  
NV V Bezludnaya ◽  
IB B Bashkova ◽  
...  
Keyword(s):  
Federal State ◽  
Dominant Form ◽  
Patient’S Satisfaction ◽  
Prosthetic Joints ◽  
Clinical Observations ◽  
Autosomal Dominant Form ◽  
Positive Results ◽  
Federal Center

Aim - to evaluate the efficacy of treatment of secondary arthrosis of the coxofemoral joints associated with osteopetrosis using arthroplasty. Materials and methods - clinical observation of two cases of treatment of patients with autosomal dominant form of osteopetrosis who underwent total hip arthroplasty at the Federal State Budgetary Institution Federal Center of Traumatology, Orthopaedics and Endoprosthesis replacement (Cheboksary). Results. We obtained positive results and patient’s satisfaction with the function of prosthetic joints with a follow-up period of 3.5 years. This method of treatment showed its efficacy during the specified follow-up period. Arthroplasty provides relief from pain, improved quality of life and increased mobility of the joint for patients with coxarthrosis associated with osteopetrosis.

Skeletal extension in metastatic injuries of the vertebral column

1999 ◽  
Vol 80 (6) ◽  
pp. 429-430
Author(s):  
F. S. Akhmetzyanov ◽  
I. V. Shaimardanov
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Vertebral Column ◽  
Palliative Therapy ◽  
Pelvic Organ ◽  
Clinical Observations ◽  
The Given

The experience of using the skeletal extension in patients with metastatic injuries of the vertebral column with the danger of squeezing the spinal cord or with the developed squeezing in combination with disorders of pelvic organ functions is shown. On the basis of the given clinical observations it is concluded that the skeletal extension is one of the methods of palliative therapy. The method makes it possible to decrease the doses of narcotic and innarcotic analgetics or to abolish them, improves the quality of life, does not require additional economic expense.

scholarly journals Feline arterial thromboembolism: prognostic factors and treatment

2018 ◽  
Vol 87 (3) ◽  
pp. 164-175
Author(s):  
L. Locquet ◽  
D. Paepe ◽  
S. Daminet ◽  
P. Smets
Keyword(s):  
Prognostic Factors ◽  
Clinical Presentation ◽  
Term Survival ◽  
Adequate Treatment ◽  
Arterial Thromboembolism ◽  
Key Points ◽  
The Individual

Feline arterial thromboembolism (ATE) is a complete or partial obstruction of a peripheral artery caused by a thrombus that was formed at a distant site. The most common underlying cause in cats is cardiomyopathy. Given the clinical presentation, often without preceding signs, an ATE event is considered one of the most distressing emergency conditions in feline practice. Often, these cats are euthanized at the time of diagnosis. However, recent scientific research has shown that a subpopulation of these patients may have long-term survival. In case of adequate treatment and follow-up, some cats survive over a year with a satisfying quality of life. Key points of ATE are the identification of specific prognostic factors in the individual patient in order to guide owner communication, the decision to treat or not to treat, individually adjusted patient management and regular monitoring, which are discussed in this article.

scholarly journals THE COMPARATIVE ASPECTS OF TWO MODIFICATIONS OF GASTRIC RESECTION ACCORDING T. BILLROTH TECHNIQUE IN ONCOLOGIC PRACTICE

2018 ◽  
Vol 24 (3) ◽  
pp. 151-156
Author(s):  
Temuri Sh. Morgoshia
Keyword(s):  
Digestive Tract ◽  
Gastric Resection ◽  
Functional Results ◽  
Malignant Neoplasms ◽  
Billroth Ii ◽  
Billroth I ◽  
The Given ◽  
Methods Of Treatment ◽  
Main Factor

The surgical intervention implying total ablation of tumor, continues to be the only method giving hope for recovery of patient despite a significant number of combined and complex methods of treatment of the given disease. However, many positions of the given conception underwent cardinal changes. Nowadays, most of authors recommend after gastric resection to restore to the extent possible natural anatomic relationships that provides best functional results. At the same time, certain researchers give preference to Billroth-II mode and at that some of them are devoted opponents of gastric resection by Billroth-I mode in case of cancer. This opinion is based on supposition that gastric resection by Billroth-II mode provides in greater extent radicalism in case of treatment of malignant neoplasms of given localization. The main factor restraining application of this most physiological operation is established opinion alleging its oncologic non-efficacy. The thesis is substantiated that intervention into modification of operation according Billroth method does not result in increasing of number of post-operative complications and that there is no differences also in distant results of surgical treatment of gastric cancer in case of application of both modes of restoration of continuity of digestive tract after sub-total distal resection. At the same time, quality of life of patients becomes better after reconstruction of digestive tract using gastroduodenal anastomosis. Most of researchers, studying indications to sub-total gastric resection using method Billroth-I, assume that it is reasonable to apply this particular mode of restoration of continuity of gastrointestinal tract only in case of early cancer, its exophytic forms (stage I and II) located in area of stomach angle or its low one third of its body and absence of metastases into regional lymphatic nodes.

scholarly journals Procena stepena zastojnih promena na gornjim urinarnim putevima kod pacijenata podvrgnutih ilealnom konduitu kao vidu derivacije urina u odnosu na vrstu insercije uretera

2013 ◽  
Vol 60 (3) ◽  
pp. 17-24
Author(s):  
B.M. Kajmakovic ◽  
Z.M. Dzamic ◽  
T. Pejcic ◽  
B. Milkovic ◽  
M. Acimovic ◽  
...  
Keyword(s):  
Renal Function ◽  
Urinary Tract ◽  
Ileal Conduit ◽  
Upper Urinary Tract ◽  
Intestinal Segment ◽  
Physiological Level ◽  
Adequate Treatment ◽  
Renal Deterioration

Substitution of the bladder with segment of the digestive tract, within the radical treatment of bladder cancer, as well as treatment of the other bladder abnormality, is extremely demanding surgical procedure, that aims adequate treatment of the underlying disease and provide patient?s renal function within physiological level. Surgical implantation of the ureter into the intestinal segment are an important part of the surgical technique, the formation of ileal conduit, with the ultimate aim of providing a more natural way of evacuation of urine from the upper urinary tract in terms of maintaining the adequate quality of renal function. Which of the existing surgical method of implantation of ureter in the intestinal segment will be applied, it is for urologist to decided, according to his affinity and/or his operating school of origin. The literature describes many procedures of this technique (Wallace A, B Wallace, Nesbit-Bricker, Le Duc). Bearing in mind that the ileal conduit, as a form of supravesical derivation, is still one of most widely used method of urinary diversion, with a very large number of patients during the follow-up period were recorded certain complications of renal function disorders, which by some authors attributed to a type of ureterointestinal anastomoses, during the creation of ileal conduit. Having in mind the fact of unnatural route of elimination of urine from the upper urinary tract that occurs during creation of ileal conduit, it is reasonable to expect some degree of renal deterioration. These complications require prompt resolution. Bearing in mind the fact of unnatural route of elimination of urine from the upper urinary tract that occurs during creation of ileal conduit, it is reasonable to expect that the renal function over the time will start to show signs of incipient or advanced failure7. Objective: The main objective is to show the degree of renal deterioration, postoperatively, according to the type of insertion of the ureters to the ileal conduit. Methods and patients: The study was conducted retrospectively on material of Urological Clinic, Clinical Center of Serbia and on material of Faculty of Medicine, University of Belgrade, on 193 patients, for a period of five years (2007 to 2011), with a time of postoperative follow-up of patients up to 48 months (four years). Assessment of the level of renal deteriorisation was performed by ultrasound examination during regular audits of patients during follow-up. Conclusion: It was found that all three examed techniques in an insertion of ureter into ileal conduit were equally satisfactorily, with the similar degree of postoperative complications. Based on these facts, we can conclude, that the quality of life of patients in all three analyzed groups of ureteral insertion in the ileal conduit, approximately the same.

scholarly journals ASSESSMENT OF QUALITY OF RENDERING PALLIATIVE CARE TO THE ONCOLOGY PATIENTS

2017 ◽  
Vol 20 (7) ◽  
pp. 177-187
Author(s):  
E.P. Gladunova
Keyword(s):  
Palliative Care ◽  
Malignant Neoplasms ◽  
Medical Assistance ◽  
Oncology Patients ◽  
Patients With Cancer ◽  
The World ◽  
Oncological Diseases ◽  
Prevalence Of Cancer ◽  
Palliative Patients

The analysis of prevalence of cancer in the world, in Russia and on the territory of the Samara Region. The results of analysis of neglect of oncological diseases in the Samara region; the results of regression analysis of growth of oncological diseases are presented. The organization of rendering palliative care in the Samara Region is studied and assessment of provision of palliative patients with berths is carried out. The estimate of provision of patients with malignant neoplasms with drugs for pain management. Factors that reduce the quality of rendering of medical assistance to the oncology patients are revealed. Directions of improving the quality of pharmaceutical care of patients with cancer are suggested.

scholarly journals Case report: Multifocal chronic paracoccidioidomycosis in an adult

2011 ◽  
pp. 228-232
Author(s):  
Karen Zapata ◽  
Janeth Villanueva ◽  
Adriana Arrunátegui ◽  
Juana Gabriela López
Keyword(s):  
Paracoccidioides Brasiliensis ◽  
Giant Cells ◽  
Systemic Mycosis ◽  
Adequate Treatment ◽  
Lung Lesions ◽  
History Of ◽  
One Year ◽  
Lost To Follow Up

Paracoccidioides brasiliensis is the ethiological agent of one of the most prevalent systemic mycosis in Latin America, where around ten-million individuals are affected. Brazil has the highest incidence but in Venezuela, Colombia, Ecuador, and Argentina cases have also been reported. We describe a 56-year-old male with a one year history of lip, oral mucosa, and lung lesions. Granulomas and multinucleated giant cells were observed in histopathological evaluation with haematoxilyn-eosin stain. Mycologic studies (KOH and Gomori Grocott stain) showed blastoconidias with multiple budding. Serologic tests for paracoccidioidine were reactive. A diagnosis of chronic multifocal paracoccidioidomycosis was made. Initially, amphotericin B 0.7 mg/kg per day was started for fifteen days and consecutively itraconazole (400 mg/day) was administered orally with improvement of skin and lung lesions; however, an important residual fibrosis was observed. The patient was lost to follow up. We highlight the importance of an early diagnosis and adequate treatment to decrease sequelae in patient quality of life.

Dental abnormalities of a long-term survivor of a childhood hematological malignancy

2005 ◽  
Vol 29 (2) ◽  
pp. 167-174 ◽  
Author(s):  
R.S Raja Zarina ◽  
N.N. Nik-Hussein
Keyword(s):  
Dental Treatment ◽  
Haematological Malignancy ◽  
Long Term Effects ◽  
Long Term Follow Up ◽  
Oncology Treatment ◽  
Potential Clinical Impact ◽  
The Given

The treatment of haematological malignancy is multimodal and involves chemotherapy, radiotherapy and/or bone marrow transplants. With the advancement in cancer therapy, there is an increase in the survival of many children with childhood haematological malignancy. In addition, the late effect of the oncology treatment to the orofacial and dental development becomes significant in terms of the potential clinical impact that may affect the quality of life of the survivor. The severity of the long-term effects is dependent on the age of the child at initiation of treatment and whether chemotherapy is combined with radiation or not. The dental treatment may become more complex if the patient requires advanced restorative dental care and the roots malformation may complicate orthodontic treatment. Therefore these patients may require a scheduled careful preventive programme, long-term follow up, with prophylactic treatment and intervention at appropriate time to minimize the consequences of the disease and the given therapy. J Clin Pediatr Dent 29(2): 167-174, 2005

scholarly journals PAIN IN CHILDREN WITH CANCER DIAGNOSIS

2020 ◽  
Vol 20 (3) ◽  
pp. 4-9
Author(s):  
N.S. Artomova ◽  
H.O. Soloviova ◽  
O.O. Kaliuzhka ◽  
M.M. Fastovets ◽  
N.I. Hasiuk
Keyword(s):  
Young Patients ◽  
Pain Syndrome ◽  
Paediatric Oncology ◽  
Initial Assessment ◽  
Psychosocial Characteristics ◽  
Basic Principles ◽  
Pathogenetic Mechanisms ◽  
Oncological Diseases

Pain syndrome is commonly a leading syndrome of oncological and oncohematological diseases in children. Whether the condition is curable or not, the pain syndrome can almost always be controlled that can significantly improve the quality of life of young patients and their families. The presented article highlights the causes and the mechanism of the pain syndrome development in children with oncological and oncohematological diseases. Adequate identification of pathogenetic mechanisms and assessment of pain syndrome is the main goal of the initial assessment of the patient's condition, taking into account the psychosocial characteristics of the patient and his family, thus it is important for clinicians to include these criteria in initial and follow-up examinations of patients in order to provide appropriate therapeutic management. We stress on the comprehensive understanding of the aetiology and pathogenetic mechanisms of the pain syndrome in children with oncological diseases, which directly affect the strategy of overcoming the pain associated with the tumour process, treatment, and carrying out medical and diagnostic manipulations in such children. It is important for specialists in paediatric oncology and oncohematology to diagnose the general pain syndrome, which accompanies cancerous diseases. Effective analgesia requires careful monitoring of the patient’s condition and his/ her syndromic reactions during treatment. The comprehensive assessment of the pain syndrome should include a discussion of the purpose and expectations of pain therapy, changes in pain intensity, characteristics and location. The article presents the basic principles of overcoming the pain syndrome, a three-step approach to the treatment of pain syndrome in children with oncological diseases and the main characteristics and combinations of analgesic groups for pain management.

scholarly journals Experience of treatment of a patient with non-small cell lung cancer with met exon 14 skipping

2021 ◽  
pp. 154-159
Author(s):  
M. O. Mandrina ◽  
V. V. Breder ◽  
M. V. Ivanov ◽  
A. A. Lebedeva ◽  
V. V. Gorbatsevich ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Malignant Disease ◽  
Clinical Situation ◽  
Malignant Neoplasms ◽  
Molecular Testing ◽  
Tumor Treatment ◽  
Individual Approach ◽  
Oncological Diseases ◽  
The Individual

Personalized therapy is starting to play an increasing role in modern approaches to the treatment of oncological diseases. The previously existing uniform standard for each malignant disease is expanded with new options and treatment possibilities, depending on each specific clinical situation. That increases the  effectiveness of  therapy and helps to control the  disease. A  separate niche in the individual approach to anti-tumor treatment is occupied by targeted therapy of malignancies. There are a lot of mutations that can lead to the emergence of malignant neoplasms. So of all that multitude of choices the individual approach to a patient helps to select the mutations that are most likely to be found in a given patient. The research in the area of the c-MET mutation has allowed it to occupy its niche as a therapeutic target. The identification of this mutation is not included in the routine set of analyses performed for a patient with diagnosed lung adenocarcinoma. But expanding the panel of molecular testing would increase the detectability of this mutation and, as a result, improve the quality of treatment for this category of patients. This clinical case describes the experience of treatment of an elderly patient with lung adenocarcinoma, in whose tumor tissue a MET mutation was detected.

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