Acute testicular disease in children

10.12737/2899 ◽  
2014 ◽  
Author(s):  
Yuriy Bolotov ◽  
Sergey Minaev
Keyword(s):  
Testicular Disease

Spermatogenesis and testicular tumours in ageing dogs

Reproduction ◽  
2000 ◽  
pp. 443-452 ◽  
Author(s):  
MA Peters ◽  
DG de Rooij ◽  
KJ Teerds ◽  
I van Der Gaag ◽  
FJ van Sluijs
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Seminiferous Tubules ◽  
Score System ◽  
Testicular Tumours ◽  
Severe Impairment ◽  
Per Se ◽  
Testicular Disease ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

Spermatogenesis was examined in testes from 74 dogs of various breeds without clinically detected testicular disease. A modified Johnsen score system was used to determine whether spermatogenesis deteriorates with ageing. The diameter of seminiferous tubules was measured in dogs without testicular disease to examine other possible effects of ageing on tubular performance. There appeared to be no relation between age and these variables. The influence of testicular tumours on spermatogenesis was also investigated in both affected and unaffected testes. The testes of 28 dogs with clinically palpable tumours and 21 dogs with clinically non-palpable tumours were investigated. In cases of unilateral occurrence of a tumour, impairment of spermatogenesis was observed only in the affected testis of dogs with clinically detected tumours. Bilateral occurrence of tumours, whether detected clinically or non-clinically, was associated with severe impairment of spermatogenesis. The prevalence of tumours increased during ageing. Eighty-six per cent of the clinically detected and 57% of the non-clinically detected tumours were found in old dogs. Multiple types of tumour and bilateral occurrence were very common. Seminomas and Leydig cell tumours were more frequent than Sertoli cell tumours. It was concluded that spermatogenesis per se did not decrease during ageing in dogs but the occurrence of testicular tumours increased with ageing and affected spermatogenesis significantly, as reflected by a lower Johnsen score.

Testicular Disease in Childhood B-Cell Non-Hodgkin’s Lymphoma: The French Society of Pediatric Oncology Experience

2001 ◽  
Vol 19 (9) ◽  
pp. 2397-2403 ◽  
Author(s):  
Jean-Hugues Dalle ◽  
Françoise Mechinaud ◽  
Jean Michon ◽  
Jean-Claude Gentet ◽  
Lionel de Lumley ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Pediatric Oncology ◽  
Hodgkin’S Lymphoma ◽  
Lymphoblastic Leukemia ◽  
Hodgkin's Lymphoma ◽  
French Society ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Testicular Disease

PURPOSE: To investigate whether testicular disease in childhood B-cell lymphoma should continue to be considered a sanctuary site, as it is with other lymphoid malignancies such as acute lymphoblastic leukemia. PATIENTS AND METHODS: Seven hundred forty-two children with B-cell non-Hodgkin’s lymphoma were included in the LMB protocols of the French Society of Pediatric Oncology from February 1981 to May 1994. Thirty patients (5.3%) had testicular involvement at diagnosis. We describe the clinical presentation and outcome of these 30 patients, who were treated without local radiation therapy. RESULTS: Five patients underwent diagnostic orchidectomy. The median patient age was 8.5 years (range, 2 to 14 years), and their cancers were stage III (18 patients), stage IV (five patients), and B-cell acute lymphoblastic leukemia (seven patients). Five patients had central nervous system involvement. Twenty-eight patients (95%) achieved complete remission. Twenty-six patients are alive without progressive disease (median follow-up, 6.5 years). CONCLUSION: Testicular disease does not seem to confer a poor prognosis, and it is curable with intensive combination chemotherapy alone. Local treatment (surgery or radiation) is avoidable; therefore, gonadal function can be preserved.

Isolated testicular relapse in acute lymphocytic leukemia of childhood: categories and influence on survival.

1984 ◽  
Vol 2 (8) ◽  
pp. 924-929 ◽  
Author(s):  
W P Bowman ◽  
R J Aur ◽  
H O Hustu ◽  
G Rivera
Keyword(s):  
Bone Marrow ◽  
Complete Remission ◽  
Acute Lymphocytic Leukemia ◽  
Clinical Course ◽  
Late Recurrence ◽  
Lymphocytic Leukemia ◽  
Drug Resistant ◽  
Prognostic Features ◽  
Resistant Disease ◽  
Testicular Disease

Isolated testicular relapse complicating first hematologic remission was identified in 31 of 521 boys with acute lymphocytic leukemia (ALL). Three categories of involvement were apparent and could be related to presenting clinical features, duration of initial complete remission, and length of hematologic remission. Among 12 patients with early testicular relapse, most had unfavorable prognostic features when ALL was first diagnosed. All but two of these children experienced marrow recurrence within seven months of testicular relapse. In contrast, the 12 patients who developed testicular disease late in their clinical course have responded much better to further therapy; ten remain in bone-marrow remission for a median of four years beyond testicular relapse. Similarly, five of the seven patients with subclinical testicular leukemia, found at elective biopsy, continue in marrow remission for prolonged periods. Early testicular recurrence is a sign of drug-resistant disease; late recurrence after elective cessation of therapy may represent residual, incompletely treated but still responsive leukemia.

scholarly journals Diffuse testicular disease: sonographic features and significance

1985 ◽  
Vol 145 (6) ◽  
pp. 1221-1224 ◽  
Author(s):  
BR Subramanyam ◽  
SC Horii ◽  
S Hilton
Keyword(s):  
Testicular Disease

TESTICULAR DISEASE

BMJ ◽  
1937 ◽  
Vol 1 (3966) ◽  
pp. 75-75
Keyword(s):  
Testicular Disease

scholarly journals Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation

Leukemia ◽  
2005 ◽  
Vol 19 (8) ◽  
pp. 1399-1403 ◽  
Author(s):  
N Hijiya ◽  
W Liu ◽  
J T Sandlund ◽  
S Jeha ◽  
B I Razzouk ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Local Irradiation ◽  
Therapeutic Role ◽  
Testicular Disease

Clinical Approach to Testicular Disease

2009 ◽  
pp. 257-259
Author(s):  
Sergio Cosciani Cunico ◽  
Tiziano Zanotelli ◽  
Mauro Scanzi
Keyword(s):  
Clinical Approach ◽  
Testicular Disease

URINARY GONADOTROPHIN EXCRETION IN HYPOGONADAL MEN

1965 ◽  
Vol 32 (2) ◽  
pp. 237-243 ◽  
Author(s):  
J. S. M. HUTCHINSON ◽  
J. M. WORDEN ◽  
F. T. G. PRUNTY
Keyword(s):  
Lower Limit ◽  
Extraction Method ◽  
Klinefelter Syndrome ◽  
Seminiferous Tubules ◽  
Syndrome Type ◽  
Normal Range ◽  
Mouse Uterus ◽  
Clear Cut ◽  
Lower Limits ◽  
Testicular Disease

SUMMARY Gonadotrophin excretion in 50 hypogonadal males has been investigated by the kaolin-acetone extraction method and the mouse uterus test. Patients with panhypopituitarism had values for gonadotrophin excretion below the normal range while those thought to have gonadotrophin insufficiency not due to hypopituitarism had values either below or around the lower limit of the normal range. Patients with primary testicular failure, involving both seminiferous tubules and interstitial cells, including those of the Klinefelter syndrome type, usually had a high gonadotrophin excretion. Patients with failure of the seminiferous tubules had values within the normal range only. In patients with gynaecomastia without evidence of testicular disease, gonadotrophin excretion was usually normal. The differentiation of abnormal levels, particularly at the lower limits, was not always clear-cut.

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