scholarly journals THE STATE OF THE IMMUNE SYSTEM IN WOMEN IN THE SECOND TRIMESTER OF PREGNANCY AT EXACERBATION OF CHRONIC SIMPLE BRONCHITIS CAUSED BY INFLUENZA A(H3N2)

2017 ◽  
Vol 1 (66) ◽  
pp. 50-53
Author(s):  
Леонид Нахамчен ◽  
Leonid Nakhamchen ◽  
Игорь Гориков ◽  
Igor Gorikov ◽  
Виктор Колосов ◽  
...  
Keyword(s):  
Optical Density ◽  
Influenza A ◽  
Immunoglobulin A ◽  
Second Trimester ◽  
Local Immunity ◽  
The Third ◽  
Persistent Virus Infection ◽  
Antibody Titers ◽  
Persistent Virus ◽  
Secretory Immunoglobulin

The contents of anti-influenza antibodies, secretory immunoglobulin A (sIgA) and circulating immune complexes (CIC) were studied in 145 women in the second trimester of pregnancy. All women were divided into 5 groups. The first group included 30 women with the physiologic course of pregnancy. The second one consisted of 30 patients with chronic simple bronchitis (CB) in remission. The third group had 30 patients with the exacerbation of CB caused by influenza A(H3N2) (antibody titers were 1:16-1:64); the fourth group included 30 patients with CB, whose exacerbation was caused by influenza (antibody titers were 1:32-1:128). It was found out that in the second group there were higher concentrations of sIgA (7.34±0.37 mg/L) and CIC (0.191±0.006 units of optical density), than in the first group (5.86±0.43 mg/L, p<0.05 and 0.095±0.003 units of optical density, respectively, p<0.001). It can probably be explained by the stimulating influence of persistent virus infection on the local immunity and its important role in the development of autoimmune responses in pregnant women. In the fifth group unlike the third group there were registered minimal contents of sIgA: 3.86±0.25 mg/L (p<0.001) and maximal level of CIC: 0.232±0.006 units of optical density (p<0.001). The revealed changes suggested the decrease of local immune protection of airways and autoimmune alteration of a woman’s body caused by high intensity of humoral immunity to influenza virus A(H3N2) under exacerbation of chronic simple bronchitis in patients in the second trimester of gestation.

THE STATE OF THE IMMUNE SYSTEM IN WOMEN IN THE SECOND TRIMESTER OF PREGNANCY AT EXACERBATION OF CHRONIC SIMPLE BRONCHITIS CAUSED BY INFLUENZA A(H3N2)

2017 ◽  
pp. 7-7
Author(s):  
Леонид Нахамчен ◽  
Leonid Nakhamchen ◽  
Игорь Гориков ◽  
Igor Gorikov ◽  
Виктор Колосов ◽  
...  
Keyword(s):  
Optical Density ◽  
Influenza A ◽  
Immunoglobulin A ◽  
Second Trimester ◽  
Local Immunity ◽  
The Third ◽  
Persistent Virus Infection ◽  
Antibody Titers ◽  
Persistent Virus ◽  
Secretory Immunoglobulin

The contents of anti-influenza antibodies, secretory immunoglobulin A (sIgA) and circulating immune complexes (CIC) were studied in 145 women in the second trimester of pregnancy. All women were divided into 5 groups. The first group included 30 women with the physiologic course of pregnancy. The second one consisted of 30 patients with chronic simple bronchitis (CB) in remission. The third group had 30 patients with the exacerbation of CB caused by influenza A(H3N2) (antibody titers were 1:16-1:64); the fourth group included 30 patients with CB, whose exacerbation was caused by influenza (antibody titers were 1:32-1:128). It was found out that in the second group there were higher concentrations of sIgA (7.34±0.37 mg/L) and CIC (0.191±0.006 units of optical density), than in the first group (5.86±0.43 mg/L, p<0.05 and 0.095±0.003 units of optical density, respectively, p<0.001). It can probably be explained by the stimulating influence of persistent virus infection on the local immunity and its important role in the development of autoimmune responses in pregnant women. In the fifth group unlike the third group there were registered minimal contents of sIgA: 3.86±0.25 mg/L (p<0.001) and maximal level of CIC: 0.232±0.006 units of optical density (p<0.001). The revealed changes suggested the decrease of local immune protection of airways and autoimmune alteration of a woman’s body caused by high intensity of humoral immunity to influenza virus A(H3N2) under exacerbation of chronic simple bronchitis in patients in the second trimester of gestation.

scholarly journals Recombinant Immunoglobulin A Specific for Influenza A Virus Hemagglutinin: Production, Functional Analysis, and Formation of Secretory Immunoglobulin A

2015 ◽  
Vol 28 (3) ◽  
pp. 170-178 ◽  
Author(s):  
Kentaro Shoji ◽  
Tadanobu Takahashi ◽  
Kohta Kurohane ◽  
Koki Iwata ◽  
Takeshi Matsuoka ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Influenza A Virus ◽  
Influenza A ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Secretory Immunoglobulin

scholarly journals IMMUNOLOGICAL AND PATHOPHYSIOLOGICAL LAWS OF LOCAL IMMUNITY ORAL CAVITY PREVENTION OF INFLAMMATORY COMPLICATIONS OF TREATMENT OF DENTOALVEOLAR ANOMALIES

2018 ◽  
Vol 22 (1) ◽  
pp. 25-28
Author(s):  
Pavel Aleksandrovich Zheleznyi ◽  
K. S Shchelkunov ◽  
S. P Zheleznyi ◽  
A. P Zheleznaia ◽  
Y. N Belousov
Keyword(s):  
Orthodontic Treatment ◽  
Antimicrobial Agents ◽  
Immunoglobulin A ◽  
Interleukin 4 ◽  
Activity Levels ◽  
Local Immunity ◽  
Immunomodulatory Agents ◽  
Periodontal Tissues ◽  
Mixed Saliva ◽  
Secretory Immunoglobulin

The state of local immunity oral factors in orthodontic treatment with fixed structures in 192 people aged 18-25 years. The mixed saliva was determined lysozyme activity levels of secretory immunoglobulin A, interleukin 1в and interleukin 4 dynamics. It was found that orthodontic treatment leads to activation of the inflammatory process in periodontal tissues, effective therapy which should be based on the integrated use of antimicrobial agents and immunomodulatory agents.

THE STATE OF HUMORAL IMMUNITY IN PAIRS “MOTHER-CHILD” AT INFLUENZA A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

2016 ◽  
Vol 1 (61) ◽  
pp. 66-68
Author(s):  
Луценко ◽  
Mikhail Lutsenko ◽  
Гориков ◽  
Igor Gorikov ◽  
Андриевская ◽  
...  
Keyword(s):  
Antibody Titer ◽  
Influenza A ◽  
Influenza Infection ◽  
First Trimester ◽  
Full Term ◽  
Fourth Group ◽  
The Third ◽  
Umbilical Blood ◽  
Antibody Titers ◽  
Somatic Diseases

At full-term pregnancy the level of anti-influenza antibodies in 126 pairs “mother-child” at influenza A(H3N2) in the first trimester of gestation was studied. The first group (comparison) was made of 40 pairs “mother-child” at pregnancy not complicated with acute respiratory virus infection, but with exacerbation of somatic diseases as well as moderate and severe somatic and obstetric pathology. The second group consisted of 43 pairs “mother-child” with influenza infection with antibody titer 1:4-1:16; the third group had 41 pairs “mother-child” with influenza А(Н3N2) with antibody titer 1:8-1:32; the fourth group had 42 pairs “mother-child” with influenza infection (antibody titers were 1:32-1:128) associated with the threat of miscarriage at early stages of gestation. It was found out that in the second group in 80% of cases mothers had higher titers of anti-virus antibodies in comparison with the titers of their children; in 12.5% of cases there were equal titers of antibodies in maternal and umbilical blood. In the second and the third groups unlike the first one there was a tendency to the decrease of a number of pairs that had higher titers of antibodies in mothers and there was an increase of pairs with equal titers of anti-virus antibodies. In the fourth group the number of pairs with domination of titers of anti-influenza antibodies increased till 28.6% in children in comparison with the titers in their mothers (in the second group it was in 4.7%, р&#60;0.05), which suggested antenatal infecting of full term newborns.

scholarly journals FOR HIGHLY PATHOGENIC INFLUENZA A(H1N1) IN PREGNANCY AND IMPACT ON BIRTH OUTCOMES

2018 ◽  
Vol 23 (3) ◽  
pp. 119-125
Author(s):  
M. G. Avdeeva ◽  
O. R. Gafurova
Keyword(s):  
Nervous System ◽  
Pregnant Women ◽  
Influenza A ◽  
Intrauterine Infection ◽  
First Trimester ◽  
Second Trimester ◽  
Third Trimester ◽  
Highly Pathogenic ◽  
The Third ◽  
Influenza A H1n1

The purpose of this study was to improve the diagnosis of influenza A (H1N1) in pregnant women and to determine the risk of developing various types of pathology in newborns, depending on the gestation period at which the infection influenza occured. Materials and methods. A total of 94 pregnant women, an average age of 28.7 ± 0.48, who were on treatment with influenza diagnosis in the Specialized Infectious Disease Clinical Hospital of the Ministry of Health of the Krasnodar Territory during the epidemic rise of influenza A (H1N1) from December 2015 to February 2016. The diagnosis of influenza A (H1N1) was confirmed in all cases by the isolation of RNA of influenza A (H1N1) virus by PCR in a nasopharyngeal scrap. Patients applied for medical care on average 2.74 ± 0.16 days of illness. Pregnancy at the gestational age corresponding to the first trimester was in 20 (21.3%), in the term of the second trimester - in 36 (38.3%), and in the third trimester - in 38 (40.4 %) of women. The results of the laboratory examination were evaluated. Pregnancy outcomes were traced in 94 women, a telephone questioning of women was conducted 3-6 months after childbirth, the state of children at birth was analyzed based on the results of a retrospective analysis of 91 neonatal card in the maternity hospital. Results. Highly pathogenic influenza A (H1N1) in pregnant women during early treatment and prescription of antiviral therapy was mainly in medium-heavy form (96.81%). In the first day of the disease, subfebrile fever predominated - 63.3%, febrile fever subsequently developed in 53.33%, headache, and other intoxication manifestations were less than in the case of epidemical influenza A. Catarrhal syndrome is not bright, often characterized by early joint cough. The main complication of influenza, determining the severity of the patient state, was pneumonia, developed in one third of patients. Early antibacterial and antiviral therapy in most cases prevented the formation of severe lung lesions and abortion. Pregnancy ended with urgent deliveries in 89 women (94.68%); in three cases, in women who had influenza at 6, 15 and 29 weeks of gestation, abortion with fetal death (3.19%) occurred. Premature delivery at 28 and 33 weeks of gestation with the birth of a viable child occurred in two cases (2.13%). The development of influenza in the first trimester resulted in complications in 42% of cases, increasing the risk of abortion and developmental anomalies, mainly from the cardiovascular system (26.31%). Infection of pregnant women with influenza in the second trimester led to a different pathology of newborns in 49% cases. Among them, acute intranatal asphyxia prevailed (14.29%), pathology of the nervous system (11.43%), less frequently developed intrauterine infection, pneumonia (5.71%). Special attention is required by women with influenza in the third trimester of pregnancy, in this group, the pathology of the newborns was noted in 54% of cases, mainly in the form of acute intranatal asphyxia (29.73%) against the background of intrauterine infection, pneumonia (16.22%), central nervous system pathology (8.11%). The conclusion. Despite the medium-heavy course, the woman’s influenza had an adverse effect on the formation of the fetus and the condition of the newborn at birth. On the background of influenza infection, the degree and nature of exposure depended on the gestation period.

scholarly journals Changes in Local Immunity Factors in Women with Pre-Existing Cervical Disease and Benign Ovarian Tumors

2017 ◽  
Vol 24 (3) ◽  
Author(s):  
Nazar Matviykiv
Keyword(s):  
Menstrual Cycle ◽  
Proinflammatory Cytokine ◽  
Immunoglobulin A ◽  
Ovarian Tumors ◽  
Secretory Immunoglobulin A ◽  
Local Immunity ◽  
Cytokine Synthesis ◽  
Benign Ovarian Tumors ◽  
Cervical Diseases ◽  
Secretory Immunoglobulin

The objective of the research was to study the indices of local immunity in relation to the hormonal state of the body in women with benign ovarian tumors and pre-existing cervical diseases.Materials and methods. The concentration of major gonadotropic and steroid hormones during the female ovarian and menstrual cycle, as well as individual local immunity factors of proinflammatory cytokines and secretory immunoglobulin A was studied in 40 patients with benign ovarian tumors and pre-existing cervical diseases.Results and discussion. In the second phase of the ovarian and menstrual cycle, a significant reduction (by 3.0 times) in the concentration of progesterone and relative hypoestrogenism (by 1.5 times as compared to the control data) were found. Anovulation was observed in 40.00% of cases and corpus luteum deficiency syndrome was diagnosed in 62.5% of women. The assessment of secretory immunoglobulin A concentration allowed us to note (along with the hypersecretion of proinflammatory cytokines) an increase in this marker in half of the examined women in the presence of chronic cervicitis and vaginitis, candidiasis and viral lesion - along with the activation of proinflammatory cytokine depression of secretory immunoglobulin A synthesis as compared to the control data.Conclusions. Local immunity changes in women with benign ovarian tumors and pre-existing cervical diseases are accompanied by abnormalities of the hormonal profile and the association of maladaptive changes in the system of local immunity manifested by fluctuations in the level of secretory immunoglobulin A during the secretory phase of the menstrual cycle and an increase in proinflammatory cytokine synthesis. The results of the conducted study allowed us to note a significant increase in the concentration of secretory immunoglobulin A along with the activation of proinflammatory cytokine synthesis in most women with benign ovarian tumors and pre-existing cervical diseases which confirms the development of acute inflammatory reactions on the background of the existing hormonal imbalance. In patients with pre-cancerous cervical diseases, there was a tendency toward depression of secretory immunoglobulin A synthesis, a significant inhibition of local immunity, especially typical for cervical intraepithelial neoplasia on the background of human papillomavirus infection. All the aforementioned data confirm the formation of secondary immunodeficiency in this category of patients. 

THE METHOD OF EARLY DIAGNOSTICS OF THE THREAT OF MISCARRIAGE UNDER PRIMARY PLACENTAL INSUFFICIENCY IN WOMEN WITH INFLUENZA A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

2016 ◽  
Vol 1 (62) ◽  
pp. 59-63 ◽  
Author(s):  
Михаил Луценко ◽  
Mikhail Lutsenko ◽  
Игорь Гориков ◽  
Igor Gorikov ◽  
Ирина Андриевская ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Blood Serum ◽  
Optical Density ◽  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Early Diagnostics ◽  
Influenza Virus A ◽  
The Third ◽  
Antibody Titers ◽  
The Right

To develop the method of early diagnostics of the threat of miscarriage under primary placental insufficiency in 102 women at influenza virus A(HN2) there was studied the vessel resistance in the right and left uterine arteries, ultrastructure of uterine and villous chorion; in the blood serum there were defined titers of antivirus antibodies, concentration of mean molecular peptides, seromucoid and circulating immune complexes (the main group). 30 women with physiologic course of pregnancy were included in the control group. Among the patients of the main group there were three subgroups. The first group had 36 patients with influenza virus A(H3N2) (antibody titers were 1:4-1:16), the second group had 34 pregnant women with influenza infection (antibody titers were 1:8-1:32), and the third group included 32 women with influenza virus А(Н3N2) (antibody titers were 1:32-1:128), in whom clinical and echographic signs of the threat of miscarriage developed at the 6-8th day of the disease. It was found out that in the patients of the third group at the 2-4th day of the virus infection in the blood serum there was the increase of the contents of mean molecular peptides till 0.290±0.0011 units of optical density, of seromucoid till 0.119±0.0011 units of optical density and of circulating immune complexes till 0.221±0.0021 units of optical density (in the second subgroup it was 0.259±0.0013 units of optical density, р&#60;0.001; 0.115±0.0013 units of optical density, р&#60;0.001; 0.190±0.0020 units of optical density, р&#60;0.001, respectively). This caused the increase of the value of systolic-diastolic ratio in the right uterine artery till 3.18±0.009 standard units, and in the left till 3.20±0.015 standard units (in the second group it was 2.97±0.014 standard units, р&#60;0.001 and 2.96±0.013 standard units, р&#60;0.001, respectively) and it led to the development of clinical-ultrasound signs of the threat of miscarriage at the 6-8th day of the infectious disease in 100 % of women.

scholarly journals FOR HIGHLY PATHOGENIC INFLUENZA A(H1N1) IN PREGNANCY AND IMPACT ON BIRTH OUTCOMES

2018 ◽  
Vol 23 (3) ◽  
pp. 119-125
Author(s):  
M. G. Avdeeva ◽  
O. R. Gafurova
Keyword(s):  
Nervous System ◽  
Pregnant Women ◽  
Influenza A ◽  
Intrauterine Infection ◽  
First Trimester ◽  
Second Trimester ◽  
Third Trimester ◽  
Highly Pathogenic ◽  
The Third ◽  
Influenza A H1n1

The purpose of this study was to improve the diagnosis of influenza A (H1N1) in pregnant women and to determine the risk of developing various types of pathology in newborns, depending on the gestation period at which the infection influenza occured. Materials and methods. A total of 94 pregnant women, an average age of 28.7 ± 0.48, who were on treatment with influenza diagnosis in the Specialized Infectious Disease Clinical Hospital of the Ministry of Health of the Krasnodar Territory during the epidemic rise of influenza A (H1N1) from December 2015 to February 2016. The diagnosis of influenza A (H1N1) was confirmed in all cases by the isolation of RNA of influenza A (H1N1) virus by PCR in a nasopharyngeal scrap. Patients applied for medical care on average 2.74 ± 0.16 days of illness. Pregnancy at the gestational age corresponding to the first trimester was in 20 (21.3%), in the term of the second trimester - in 36 (38.3%), and in the third trimester - in 38 (40.4 %) of women. The results of the laboratory examination were evaluated. Pregnancy outcomes were traced in 94 women, a telephone questioning of women was conducted 3-6 months after childbirth, the state of children at birth was analyzed based on the results of a retrospective analysis of 91 neonatal card in the maternity hospital. Results. Highly pathogenic influenza A (H1N1) in pregnant women during early treatment and prescription of antiviral therapy was mainly in medium-heavy form (96.81%). In the first day of the disease, subfebrile fever predominated - 63.3%, febrile fever subsequently developed in 53.33%, headache, and other intoxication manifestations were less than in the case of epidemical influenza A. Catarrhal syndrome is not bright, often characterized by early joint cough. The main complication of influenza, determining the severity of the patient state, was pneumonia, developed in one third of patients. Early antibacterial and antiviral therapy in most cases prevented the formation of severe lung lesions and abortion. Pregnancy ended with urgent deliveries in 89 women (94.68%); in three cases, in women who had influenza at 6, 15 and 29 weeks of gestation, abortion with fetal death (3.19%) occurred. Premature delivery at 28 and 33 weeks of gestation with the birth of a viable child occurred in two cases (2.13%). The development of influenza in the first trimester resulted in complications in 42% of cases, increasing the risk of abortion and developmental anomalies, mainly from the cardiovascular system (26.31%). Infection of pregnant women with influenza in the second trimester led to a different pathology of newborns in 49% cases. Among them, acute intranatal asphyxia prevailed (14.29%), pathology of the nervous system (11.43%), less frequently developed intrauterine infection, pneumonia (5.71%). Special attention is required by women with influenza in the third trimester of pregnancy, in this group, the pathology of the newborns was noted in 54% of cases, mainly in the form of acute intranatal asphyxia (29.73%) against the background of intrauterine infection, pneumonia (16.22%), central nervous system pathology (8.11%). The conclusion. Despite the medium-heavy course, the woman’s influenza had an adverse effect on the formation of the fetus and the condition of the newborn at birth. On the background of influenza infection, the degree and nature of exposure depended on the gestation period.

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