scholarly journals In-hospital rehabilitation in the treatment of multiple myeloma

2021 ◽  
Vol 11 (8) ◽  
pp. 66-74
Author(s):  
Alicja Mińko ◽  
Karina Szczypiór-Piasecka ◽  
Daniel Kotrych
Keyword(s):  
Multiple Myeloma ◽  
Musculoskeletal System ◽  
Treatment Process ◽  
Proximal Part ◽  
Rehabilitation Program ◽  
Treatment Procedure ◽  
History Of ◽  
The Right ◽  
Hospital Rehabilitation ◽  
Entire Treatment

Wprowadzenie:  Szpiczak mnogi (MM) jest jednym z najczęstszych złośliwych nowotworów kości. Podstawową procedurą leczenia szpiczaka mnogiego jest chemioterapia połączona z autologicznym przeszczepem komórek macierzystych. Leczenie operacyjne, polegające na wycięciu guza, jest wskazane, gdy istnieje ryzyko patologicznego złamania kości lub ucisku guza na korzenie nerwowe. Konieczne jest stworzenie indywidualnego planu leczenia we współpracy interdyscyplinarnej. Ważnym elementem leczenia jest pomoc w zakresie rehabilitacji. Celem pracy było wskazanie procedur rehabilitacyjnych w leczeniu szpiczaka mnogiego po rekonstrukcji endoprotezy w okresie szpitalnym.Materials and methods: The work was written based on the medical history of a patient diagnosed with multiple myeloma in the proximal part of the right femur. The entire treatment procedure was carried out at the Department of Orthopedics, Traumatology and Oncology of the Musculoskeletal System, located at Unii Lubelskiej 1 in Szczecin.Results: Rehabilitation in the treatment process of patients after resection of the tumor in the proximal part of the femur and arthroplasty is implemented as early as 1 day after the surgery in order to activate the patient as soon as possible. The rehabilitation program was as individualized as possible to the patient and included modern techniques such as osteopathy and manulana therapy.Wniosek: Rehabilitacja jest nieodzownym elementem leczenia chorych na nowotwory. Wprowadzenie do rehabilitacji nowoczesnych technik wpływa pozytywnie na skuteczność terapii. Wczesne rozpoczęcie rehabilitacji przynosi wymierne korzyści w trakcie leczenia i powrót pacjenta do aktywnego udziału w życiu społecznym.

scholarly journals Physiotherapeutic proceedings with patient after petrochanteric fracture

2021 ◽  
Vol 11 (8) ◽  
pp. 194-203
Author(s):  
Damian Babkiewicz ◽  
Karina Szczypiór-Piasecka ◽  
Alicja Mińko ◽  
Krzysztof Antczak
Keyword(s):  
Postoperative Complications ◽  
Treatment Process ◽  
Patient Activation ◽  
Trochanteric Fracture ◽  
The Elderly ◽  
Treatment Procedure ◽  
Common Cause ◽  
Lesser Trochanter ◽  
History Of ◽  
Entire Treatment

Introduction: The elderly are often affected by hip fractures. A trochanteric fracture is defined as when the fracture fissure is between the capsule and 3 cm below the lesser trochanter. The most common cause of these fractures is osteoporosis in the elderly. Treatment of a trochanteric fracture may be operative or conservative. The aim of this study was to define a plan of physiotherapeutic treatment in a patient after fixation of a trochanteric fracture with an intramedullary nail.Materials and methods: The work was written based on the medical history of a patient with a trochanteric fracture. The entire treatment procedure was carried out at the Department of Orthopedics, Traumatology and Oncology of the Musculoskeletal System, located at Unii Lubelskiej 1 in Szczecin.Results: Rehabilitation is an indispensable element in the treatment process of patients after a trochanteric fracture. It is implemented already from 1 day after the surgery in order to activate the patient as soon as possible. Such a procedure is to ensure faster activation of the patient and to avoid adverse changes resulting from too long immobilization.Conclusion: Rehabilitation is an indispensable element in the treatment of patients after a trochanteric fracture. Early patient activation reduces the risk of postoperative complications.

scholarly journals Multiple myeloma associated with IgA lambda gammopathy and multiple myeloma oncogene 1 in a Yorkshire terrier

2018 ◽  
Vol 63 (No. 4) ◽  
pp. 187-192
Author(s):  
S. Kim ◽  
E. Son ◽  
S. Lee ◽  
S. Lee ◽  
H. Kim ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cells ◽  
Weight Bearing ◽  
Serum Biochemistry ◽  
First Case ◽  
History Of ◽  
Immunofixation Electrophoresis ◽  
The Right ◽  
Yorkshire Terrier

An eight-year-old spayed female Yorkshire terrier was presented with a one-month history of conspicuous weight-bearing lameness in the right hindlimb, mild anorexia, intermittent vomiting and marked polydipsia and polyuria. Radiographs revealed circular radiolucent foci of variable size in the skeleton. Haematological and serum biochemistry examination revealed mild leucopoenia with severe neutropaenia, mild non-regenerative anaemia, moderate thrombocytopoenia, moderate hyperglobulinaemia, mild hypoalbuminaemia, mild azotaemia and moderate hypercalcaemia. Quantification of serum immunoglobulins revealed elevated IgA and IgG. Serum protein electrophoresis showed a broad appearance with a β-region spike. Plasma cells accounted for 7.6% of the cells in the bone marrow. Serum immunofixation electrophoresis (IFE) revealed IgA lambda gammopathy. Immunohistochemistry in the bone marrow was diffusely positive for multiple myeloma oncogene 1 (MUM-1) and CD20. To our knowledge, this is first case report of multiple myeloma associated with IgA lambda gammopathy confirmed via IFE and immunohistochemical expression of MUM-1 in a dog.

scholarly journals Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression

2021 ◽  
Vol 34 (13) ◽  
Author(s):  
Miguel Silva ◽  
Joana Martins ◽  
João Pinto ◽  
Teresina Amaro
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Bone Marrow Aspiration ◽  
Normal Serum ◽  
Bone Lesions ◽  
Diagnostic Challenge ◽  
Serum Free Light Chain ◽  
Cytokeratin Expression ◽  
History Of ◽  
The Right

Non-secretory multiple myeloma is a rare form of the disease that presents a diagnostic challenge. A 69-year-old woman presented to the emergency department with a pathological fracture of the right clavicle, along with a history of asthenia and middle back pain in the preceding three months. Workup revealed multiple focal lytic bone lesions in the clavicles, ribs, skull and thoracic- lumbar-sacral spine, without evidence of anemia, hypercalcemia or renal failure, with no abnormal immunofixation in the serum or urine and with normal serum free light chain ratios. The Iliac crest bone marrow aspiration and biopsy revealed a scarcely involved marrow, However, biopsy of one of the focal bone lesions revealed a hypercellular bone marrow with phenotypically abnormal plasmocytes, along with an intriguing, albeit aberrant, cytokeratin expression. Non-secretory multiple myeloma is in itself a rare diagnosis. However, the combination of a patchy marrow involvement and aberrant cytokeratin expression makes this a noteworthy presentation.

scholarly journals Diplopia and proptosis due to isolated lateral rectus plasmacytoma in a patient with multiple myeloma

2019 ◽  
Vol 12 (7) ◽  
pp. e229178 ◽  
Author(s):  
Norman Saffra ◽  
Farzan Gorgani ◽  
David Panasci ◽  
David Kirsch
Keyword(s):  
Multiple Myeloma ◽  
Systemic Disease ◽  
Rectus Muscle ◽  
Extramedullary Plasmacytoma ◽  
Lateral Rectus ◽  
Muscle Belly ◽  
Lateral Rectus Muscle ◽  
History Of ◽  
The Right ◽  
Orbital Radiation

Orbital involvement of multiple myeloma (MM) is uncommon, with most of those reported cases occurring at the time of initial diagnosis of MM. We present a case of an extramedullary plasmacytoma involving only the right lateral rectus of a patient who had been in disease remission. The patient presented with new-onset diplopia and an abduction deficit of the right eye, with mild proptosis. In light of her past medical history of MM, an orbital MRI was obtained. The MRI demonstrated an isolated finding of eccentric enlargement of the right lateral rectus muscle limited to the muscle belly with sparing of the tendinous insertions, leading to diagnosis of plasmacytoma. Patching of the involved eye to alleviate the symptoms of diplopia was instituted. Chemotherapy was initiated, followed by orbital radiation and stem-cell transplantation for coexisting systemic disease. The orbital symptoms of proptosis and diplopia resolved within 1 month of treatment.

scholarly journals The Use of Fibroseal in Hemophilic Cysts - A Case Report

1977 ◽  
Author(s):  
K. Anderle ◽  
Wien N. Böhler ◽  
F. Baudo ◽  
F. de Cataldo ◽  
L. Silvello
Keyword(s):  
Bone Tumors ◽  
Animal Experiments ◽  
Proximal Part ◽  
Rehabilitation Program ◽  
Bone Transplantation ◽  
New Approach ◽  
Plasma Fraction ◽  
Fibrin Sealing ◽  
The Right ◽  
First Time

Based on the good results achieved with a fibrin-sealing-system consisting of a high concentrated fibrinogen-containing plasma fraction, thrombin, and calcium chloride in animal experiments and in patients suffering from bone tumors, this sealing method was used for the first time in a severe hemophiliac. Due to a massive, fractured hemophilic cyst in the proximal part of the right femur this patient had been unable to walk for months.Combining homologous and autologous bone transplantation, fibroseal, and osteo synthesis, it was possible to avoid amputation. At present, the patient is following a rehabilitation program.The result in this case and experience gained from earlier studies indicate that the use of fibroseal for bone reconstruction offers a new approach to orthopaedic problems in hemophilia patients.

Bisphosphonate-associated osteonecrosis of the external auditory canal

2013 ◽  
Vol 127 (S2) ◽  
pp. S51-S53 ◽  
Author(s):  
N Wickham ◽  
A Crawford ◽  
A S Carney ◽  
A N Goss
Keyword(s):  
Multiple Myeloma ◽  
Temporal Bone ◽  
External Auditory Canal ◽  
Case Reports ◽  
Bone Lesion ◽  
Benign Condition ◽  
Exposed Bone ◽  
Drug History ◽  
History Of ◽  
The Right

AbstractBackground:Osteonecrosis is a benign condition characterised by necrotic exposed bone, and is associated with bisphosphonate use. Osteonecrosis of the external auditory canal is rare, with only a few reported cases.Method:Two case reports of temporal bone osteonecrosis are presented.Results:A 64-year-old man with a history of immunoglobulin G kappa multiple myeloma developed a right external auditory canal ulcer 6 years after commencement on clodronate. A 72-year-old woman taking alendronate for osteoporosis, initially diagnosed and treated for right-sided otitis externa, was found to have underlying exposed bone in the right external auditory canal, with a computed tomography scan confirming destruction of the temporal bone.Conclusion:With increasing use of both oral and intravenous bisphosphonates in the community for benign conditions such as osteoporosis and for malignant conditions such as breast cancer and multiple myeloma, the diagnosis of bisphosphonate-associated osteonecrosis should always be considered in patients with a temporal bone lesion, and a relevant drug history taken.

Advanced myeloma masquerading as chronic shoulder pain in a 48-year-old man: a diagnostic dilemma

2020 ◽  
Vol 13 (5) ◽  
pp. e231219
Author(s):  
Rajarshi Bhadra ◽  
Teodora Nikova ◽  
Meyappan Somasundaram ◽  
Keyvan Ravakhah
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Early Diagnosis ◽  
Shoulder Pain ◽  
Pathologic Fracture ◽  
Diagnostic Dilemma ◽  
History Of ◽  
Low Threshold ◽  
The Right ◽  
Chronic Shoulder Pain

Although solitary plasmacytomas may occasionally present as collar bone swellings or fractures, multiple myeloma involving clavicle is extremely rare. Ten to forty per cent of multiple myeloma cases are asymptomatic and are incidental diagnoses. Our case report describes an entirely benign presentation like chronic shoulder pain masquerading advanced myeloma, thereby posing a significant diagnostic dilemma. We present a 48-year-old man who presented with chronic bilateral shoulder pain with no history of trauma and was eventually diagnosed with advanced multiple myeloma and pathologic fracture of the right clavicle. It is, therefore, evident that a low threshold for suspicion can lead to early diagnosis and initiation of treatment and better survival.

scholarly journals Detection of significant left renal artery stenosis caused by fibromuscular dysplasia with selective angiography

2020 ◽  
Vol 91 (4) ◽  
pp. 269-271
Author(s):  
Ramezan Jafari ◽  
Zohreh Rostami ◽  
Mohammad Nikpoor ◽  
Mohammad Javanbakht ◽  
Mohsen Sadeghi Ghahroudi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Fibromuscular Dysplasia ◽  
Good Control ◽  
Proximal Part ◽  
Computed Tomographic Angiography ◽  
Left Renal Artery ◽  
Computed Tomographic ◽  
History Of ◽  
The Right

A 22-year-old female, was referred with a history of a headache and elevated blood pressure without family history of hypertension or familial dyslipidemia. Initially, a spiral computed tomographic angiography of the renal arteries was conducted, demonstrating completely abnormal left renal artery at the medial portion of the vessel with suspicious stenosis, which was supposed to be due to fibromuscular dysplasia (FMD). Subsequently, the patient underwent selective renal angiography and balloon angioplasty. Severe stenosis was observed on the left side and moderate stenosis on the right side in the medial and proximal part of the vessels, respectively. After the diagnosis of FMD, the left side was treated by balloon and finally, the patient was discharged with good control of blood pressure by losartan/amlodipine treatment.

scholarly journals An unusual cause of hemoptysis due to leaking subclavian artery pseudoaneurysm secondary to trauma

2017 ◽  
Vol 6 (1) ◽  
pp. 359
Author(s):  
Yugandhar Bhatt ◽  
Waseem Md Abdul ◽  
Misba Zahera
Keyword(s):  
Subclavian Artery ◽  
Case Reports ◽  
Proximal Part ◽  
Blunt Injury ◽  
Lobe Bronchus ◽  
Complete Evaluation ◽  
Artery Pseudoaneurysm ◽  
History Of ◽  
The Right ◽  
Resection And Anastomosis

Pseudoneurysms of the subclavian artery after blunting thoracic trauma presenting with a complication of hemoptysis are rare, most of which occur early, within days of trauma and represent a challenging surgical problem. Only a few scattered case reports are found in the literature. Here, we present the case of a 36-year-old male, with a history of blunt injury to the chest with right clavicular fracture, a few years back, who presented with cough, hemoptysis and shortness of breath of five days duration. On complete evaluation it was found that these complaints were due to a sub clavian artery pseudo aneurysm in the proximal part, which is compressing on the right upper lobe bronchus and blood leaking into the parenchyma and airways producing the symptoms. He was managed conservatively and stabilized. Later aneurysm resection and anastomosis was done electively. The patient is now asymptomatic and healthy.

Z-line degradation and phagocytosis of sarcomeric fragments in myonecrosis

1983 ◽  
Vol 41 ◽  
pp. 790-791
Author(s):  
Melinda L. Estes ◽  
Samuel M. Chou
Keyword(s):  
Vastus Lateralis ◽  
Inflammatory Myopathy ◽  
Muscle Disease ◽  
White Female ◽  
Inflammatory Cell Infiltrate ◽  
Limb Weakness ◽  
Muscle Diseases ◽  
History Of ◽  
The Right ◽  
Mononuclear Inflammatory Cell

Many muscle diseases show common pathological features although their etiology is different. In primary muscle diseases a characteristic finding is myofiber necrosis. The mechanism of myonecrosis is unknown. Polymyositis is a primary muscle disease characterized by acute and subacute degeneration as well as regeneration of muscle fibers coupled with an inflammatory infiltrate. We present a case of polymyositis with unusual ultrastructural features indicative of the basic pathogenetic process involved in myonecrosis.The patient is a 63-year-old white female with a one history of proximal limb weakness, weight loss and fatigue. Examination revealed mild proximal weakness and diminished deep tendon reflexes. Her creatine kinase was 1800 mU/ml (normal < 140 mU/ml) and electromyography was consistent with an inflammatory myopathy which was verified by light microscopy on biopsy muscle. Ultrastructural study of necrotizing myofiber, from the right vastus lateralis, showed: (1) degradation of the Z-lines with preservation of the adjacent Abands including M-lines and H-bands, (Fig. 1), (2) fracture of the sarcomeres at the I-bands with disappearance of the Z-lines, (Fig. 2), (3) fragmented sarcomeres without I-bands, engulfed by invading phagocytes, (Fig. 3, a & b ), and (4) mononuclear inflammatory cell infiltrate in the endomysium.

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