Toxicological Effects of Viper Cerastes Cerastes Crude Venom on Serum Indices of Male Albino Rats = التأثيرات السمية الناتجة عن السم الخام للحية المقرنة على مؤشرات مصل ذكور الجرذان البيضاء

2015 ◽  
Vol 15 (2) ◽  
pp. 173-182
Author(s):  
Samira M. Saleh ◽  
Naglaa R. A. Kasem
Keyword(s):  
Albino Rats ◽  
Crude Venom ◽  
Toxicological Effects

scholarly journals The Effect of Venom of Egyptian Spitting Cobra Naja nubiae on Vascular Permeability of Hepatic and Renal Tissues

2021 ◽  
Vol 9 (1) ◽  
pp. 22-25
Author(s):  
Asmaa Saad Mahmoud Shokhba ◽  
Mohamed A. Abdel-Rahman ◽  
Mohammed Alaa El-Deen A. Omran ◽  
Nahla Soliman El-Shenawy
Keyword(s):  
Body Weight ◽  
Vascular Permeability ◽  
Saline Solution ◽  
Public Awareness ◽  
Control Group ◽  
Albino Rats ◽  
Colorimetric Determination ◽  
Crude Venom ◽  
Treatment Groups ◽  
Renal Vascular

Background: Among venomous elapid snakes, cobras have the highest public awareness, as their venom represents a combination of proteins, peptides, and enzymes that have a range of biochemical and pharmacological roles and are also the main constitutes of biological activity and lethal toxicity. Objectives: The study aimed to evaluate the effect of the venom of Egyptian Spitting Cobra, Naja nubiae, on the vascular permeability based on the extravasation of the azo dye Evans blue (EB) into the tissues of the liver and kidneys of animals envenomed with low (¼ LD50; 0.32 mg/kg) and high (½ LD50; 0.65 mg/ kg) doses at three sampling times (30, 120, 360 min) post-injection of the venom. Methods: Fifty-four adult male Albino rats (8 weeks old and 180±2 0 g body weight) were divided into three main groups (n=6). In the control group, rats were subcutaneously (SC) injected with saline solution. Envenomed groups were SC injected, one group with 0.32 mg/kg and the other group with 0.65 mg/kg body weight of crude venom, respectively. Rats were I.V injected with EB dye 20 minutes before SC injection with saline solution as control animals and with Naja nubiae venom as treatment groups. Results: The results illustrated a high significant rate of EB extravasation to hepatic and renal tissues by the colorimetric determination of EB dye concentration. Conclusion: The venom of Naja nubiae can cause increased hepatic and renal vascular permeability which may explain the inflammatory effect induced by this venom.

scholarly journals Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.

2021 ◽  
Vol 0 (0) ◽  
pp. 1-12
Author(s):  
omima mohamed ◽  
nermine hassan ◽  
islam mitwalli ◽  
asmaa hussein
Keyword(s):  
Albino Rats ◽  
Toxicological Effects

Lactic acid bacteria bio-detoxified aflatoxins contaminated cereals, ameliorate toxicological effects and improve haemato-histological parameters in albino rats

Toxin Reviews ◽  
2020 ◽  
pp. 1-12
Author(s):  
Olukayode Adebola Ibitoye ◽  
Oladipo Oladiti Olaniyi ◽  
Clement Olusola Ogidi ◽  
Bamidele Juliet Akinyele
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Albino Rats ◽  
Toxicological Effects

Entomotoxic effects of synthesized aluminum oxide nanoparticles against Sitophilus oryzae and their toxicological effects on albino rats

2021 ◽  
pp. 074823372110350
Author(s):  
Tamer Ismail ◽  
Mohamed A Salama ◽  
Mostafa Elabiary
Keyword(s):  
Aluminum Oxide ◽  
Insect Pests ◽  
Sitophilus Oryzae ◽  
Albino Rats ◽  
Oxide Nanoparticles ◽  
Histopathological Analysis ◽  
Dependent Manner ◽  
Aluminum Oxide Nanoparticles ◽  
Toxicological Effects ◽  
Stored Product Pest

Recently, nanoparticles are emerging as a potential alternative to synthetic pesticides for protection against stored-product insect pests, such as the rice weevil Sitophilus oryzae; however, the toxic effects of nanoparticles on nontarget organisms are not yet understood. Therefore, we investigated the insecticidal effects of synthesized aluminum oxide nanoparticles (Al2O3-NPs) on S. oryzae, as well as their potential toxicity in albino rats. S. oryzae mortality increased as the period of Al2O3-NP exposure increased; 100% mortality was reached at 8000 mg Al2O3-NPs/kg of wheat grain after 7 days of exposure. After 60 days of exposure, all tested Al2O3-NPs concentrations (1000, 2000, 4000, and 8000 mg/kg grain) significantly reduced the number of S. oryzae offspring in a dose-dependent manner. In albino rats, exposure to the LC90 of Al2O3-NPs in a treated diet caused a significant decrease in total body weight and an increase in liver weight in a subacute toxicity test. Moreover, Al2O3-NP treatment elevated the levels of alanine aminotransferase, aspartate aminotransferase, and creatinine in exposed rats relative to control rats, while the uric acid levels of treated rats decreased. Histopathological analysis also revealed various hepatic and renal lesions in treated rats. In summary, although Al2O3-NPs have insecticidal effects, they also have hazardous toxicological effects on rats. Therefore, if Al2O3-NPs are used in the current powder form to protect stored products, they may cause adverse effects to workers and consumers. Further research will be required to develop new nanoformulations with increased safety and potency before these nanoparticles can be used in stored-product pest control.

Sub-acute toxicological effects of Jobelyn® on pregnant albino rats

2018 ◽  
Author(s):  
Abiodun Humphrey Adebayo ◽  
Omolara Faith Yakubu ◽  
Godwin Eneji Egbung ◽  
Olabisi Ibidun Williams ◽  
Olajuwon Okubena
Keyword(s):  
Albino Rats ◽  
Toxicological Effects

Toxicological effects of cadmium during pregnancy in Wistar albino rats

2014 ◽  
Vol 6 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Jonah Sydney Aprioku ◽  
Barikpoar Ebenezer ◽  
Maxwell Azubuike Ijomah
Keyword(s):  
Albino Rats ◽  
Toxicological Effects ◽  
Wistar Albino Rats
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