GRAVIOLA LEAVES EXTRACT AMELIORATING THE RENAL ALTERATIONS INDUCED BY FOOD ADDITIVE "MONO-SODIUM GLUTAMATE" IN MALE ALBINO RATS

2018 ◽  
Vol 69 (69) ◽  
pp. 207-225
Author(s):  
Eman Abd-Ella ◽  
Abd Elkarim Abd Ellatief ◽  
Ola Nabil
Keyword(s):  
Food Additive ◽  
Albino Rats ◽  
Sodium Glutamate

scholarly journals In Vivo Comet Assay of Food Additives’ Combinations and their Effects on Biochemical Parameters in Albino Rats

2020 ◽  
Vol 11 (2) ◽  
pp. 9170-9183
Keyword(s):  
Comet Assay ◽  
Food Additives ◽  
Food Additive ◽  
Genotoxic Effect ◽  
Total Serum Protein ◽  
Total Serum ◽  
Control Group ◽  
Albino Rats ◽  
The Brain

Although the safety of food additives had been assessed individually, these permitted additives may be unsafe if used together; this study was piloted to assess the safety of various food additive mixtures. Fifty male Albino rats - Wistar strain (4 weeks old) were distributed into 10 groups, the first group orally administered distilled water, the other nine groups orally administered different mixtures of food additives at NOAEL dosage for each food additive for 30 days. Haemoglobin, malondialdehyde, kidney functions, activities of AST, ALT, and ALP. Levels of bilirubin, total protein, and albumin were also determined. Assessment of the genotoxic effect using in vivo alkaline comet assay was performed in the brain, liver, and kidney tissues. The results indicated significant Hb concentration reduction was recorded by all studied food additives’ combination compared to the control group. With the number of additives increases the Hb, total serum protein and albumin contents were significantly (p <0.05) decreased; in contrast, there was an increase in MDA, urea, creatinine, liver function enzyme activity, and bilirubin levels. Also, the examined food additives’ combinations exhibited genotoxic activities with different degrees compared to control rats in the brain, kidney, and liver, with the number of additives increases the genotoxic effect increased.

Effects of renovascular hypertension on rat adrenal zona glomerulosa

1978 ◽  
Vol 36 (2) ◽  
pp. 582-583
Author(s):  
G. Mazzocchi ◽  
P. Rebuffat ◽  
C. Robba ◽  
P. Vassanelli ◽  
G. G. Nussdorfer
Keyword(s):  
Renovascular Hypertension ◽  
Left Kidney ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Zona Glomerulosa ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Left Renal Artery ◽  
Angiotensin System ◽  
And Control

It is well known that the rat adrenal zona glomerulosa steroidogenic activity is controlled by the renin-angiotensin system. The ultrastructural changes in the rat zona glomerulosa cells induced by renovascular hypertension were described previously, but as far as we are aware no correlated biochemical and morphometric investigations were performed.Twenty adult male albino rats were divided into 2 experimental groups. One group was subjected to restriction of blood flow to the left kidney by the application of a silver clip about the left renal artery. The other group was sham-operated and served as a control. Renovascular hypertension developed in about 10 days: sistolic blood pressure averaged 165 ± 6. 4 mmHg, whereas it was about 110 ± 3. 8 mmHg in the control animals. The hypertensive and control rats were sacrificed 20 days after the operation. The blood was collected and plasma renin activity was determined by radioimmunological methods. The aldosterone concentration was radioimmunologically assayed both in the plasma and in the homogenate of the left capsular adrenal gland.

Further Studies on the Ultrastructure of Harderian Gland in Adult Rats

1974 ◽  
Vol 32 ◽  
pp. 288-289
Author(s):  
Alfredo Feria-Velasco ◽  
Guadalupe Tapia-Arizmendi
Keyword(s):  
Fine Structure ◽  
Domestic Fowl ◽  
Animal Species ◽  
Acinar Cells ◽  
Harderian Gland ◽  
Myoepithelial Cells ◽  
The Other ◽  
Albino Rats ◽  
Adult Rats ◽  
Cell Components

The fine structure of the Harderian gland has been described in some animal species (hamster, rabbit, mouse, domestic fowl and albino rats). There are only two reports in the literature dealing on the ultrastructure of rat Harderian gland in adult animals. In one of them the author describes the myoepithelial cells in methacrylate-embbeded tissue, and the other deals with the maturation of the acinar cells and the formation of the secretory droplets. The aim of the present work is to analize the relationships among the acinar cell components and to describe the two types of cells located at the perifery of the acini.

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