Clinical and Radiological Predictor of Disability among Multiple Sclerosis Patients in Ain Shams University Hospitals = المتنبئات السريرية والتصويرية للعجز في مرضى التصلب المتعدد بمستشفيات جامعة عين شمس

2015 ◽  
Vol 66 (4-6) ◽  
pp. 445-450
Author(s):  
سامية عاشور هلال ◽  
مجد فؤاد زكريا ◽  
عزة عبد الناصر عبد العزيز ◽  
هالة محمود الخواص ◽  
دينا عبد الجواد زمزم ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
University Hospitals ◽  
Multiple Sclerosis Patients

scholarly journals Early Cognitive Impairment in Multiple Sclerosis Patients In Relation To Brain Atrophy, Egyptian Sample

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M F Zakaria ◽  
T A Abdo ◽  
A A Abdelaziz ◽  
D A Zamzam ◽  
Y A Abdullah ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Brain Atrophy ◽  
General Medicine ◽  
Economic Consequences ◽  
University Hospitals ◽  
Cross Sectional ◽  
Significant Difference ◽  
Multiple Sclerosis Patients

Abstract Background Approximately half of all patients with multiple sclerosis (MS) experience cognitive impairment, most commonly with regard to new learning and memory. Cognitive dysfunction is a leading cause of disability in MS and it can have profound social and economic consequences for patients and their families. Objective This study was conducted to discover the early cognitive domains affected in multiple sclerosis patients concomitant with the postulated brain atrophy in an Egyptian sample of multiple sclerosis patients. Patients and Methods A cross-sectional observational case-control study conducted on seventy (60) patients who came for follow-up in Ain Shams University hospitals. 40 patients were taken as cases that followed up in MS unit in Ain-Shams university hospitals. 20 participants were taken as controls taken from the general medicine clinics age and sex matched to our patient group. An informed written consent was taken from parents of each person included in the study. Results There was a statistically significant difference between the two groups in brain volumetric changes and in the parameters of cognitive assessment Conclusion Early detection and examination of cognitive functions is important for patient evaluation, follow up and treatment regimen used.

scholarly journals Visual Field Changes in Multiple Sclerosis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
D E A Mansour ◽  
A M E Abdelhamid ◽  
S S M Fahmy
Keyword(s):  
Multiple Sclerosis ◽  
Visual Field ◽  
Demyelinating Disease ◽  
Visual Field Loss ◽  
University Hospitals ◽  
Mcdonald Criteria ◽  
International Panel ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Multiple Sclerosis Patients

Abstract Background multiple sclerosis (MS) is a demyelinating disease of the central nervous system and the leading cause of disability in young adults. Afferent pregeniculate visual pathways (retina, optic nerves, chiasm, and tracts) are preferential targets of inflammation, demyelination, and axonal degeneration. Aim of the Work in our study was to find and correlate visual field findings in multiple sclerosis patients with clinical data. Patients and Methods this study included 30 eyes of 17 patients previously diagnosed as multiple sclerosis according to the international panel on diagnosis of MS (McDonald criteria 2001) and its revision by Polman etal 2005. All our cases were from both sexes and of different age group ranging from 18 years old to 51 years old. there were subtypes of MS included in our study which were relapsing remitting (RR), and secondary progressive (SP). All cases were from Ain-shams university hospitals, outpatient clinics. Results this study was conducted in Ain-shams university hospitals out-patient clinics, it included 17 patients previously diagnosed as MS. The age in our study was ranging from 18 to 51 years old with mean age of 33.67± 9.37.Our cases were from both sex with prevelance of female patients. Conclusion these findings illustrate the role of perimetry in detecting both clinically overt & and clinically occult optic nerve involvement in patients with MS. It quantifies the depth of visual field loss, identifies atypical cases of optic neuritis, aids in counseling patients about prognosis.

scholarly journals Case Report: Covid-19 in Multiple Sclerosis Patients Treated With Ocrelizumab: A Case Series

2021 ◽  
Vol 12 ◽  
Author(s):  
Stefania F. De Mercanti ◽  
Marco Vercellino ◽  
Chiara Bosa ◽  
Anastasia Alteno ◽  
Valentina Schillaci ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serological Test ◽  
Severe Disease ◽  
Case Series ◽  
Case Fatality ◽  
University Hospitals ◽  
Real World Data ◽  
Large Variability ◽  
Multiple Sclerosis Patients ◽  
The Impact

Introduction: Limited data are available on the course of Coronavirus disease 2019 (COVID-19) in people with Multiple Sclerosis (MS). More real-world data are needed to help the MS community to manage MS treatment properly. In particular, it is important to understand the impact of immunosuppressive therapies used to treat MS on the outcome of COVID-19.Methods: We retrospectively collected data on all confirmed cases of COVID-19 in MS patients treated with ocrelizumab, followed in two MS Centers based in University Hospitals in Northern Italy from February 2020 to June 2021.Results: We identified 15 MS patients treated with ocrelizumab with confirmed COVID-19 (mean age, 50.47 ± 9.1 years; median EDSS, 3.0; range 1.0–7.0). Of these, 14 were confirmed by nasal swab and 1 was confirmed by a serological test. COVID-19 severity was mild to moderate in the majority of patients (n = 11, 73.3%; mean age, 49.73; median EDSS 3.0). Four patients (26.7%; mean age, 52.5 years; median EDSS, 6) had severe disease and were hospitalized; one of them died (age 50, EDSS 6.0, no other comorbidities). None of them had underlying respiratory comorbidities.Conclusion: This case series highlights the large variability of the course of COVID-19 in ocrelizumab-treated MS patients. The challenges encountered by the healthcare system in the early phase of the COVID-19 pandemic might have contributed to the case fatality ratio observed in this series. Higher MS-related disability was associated with a more severe COVID-19 course.

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