scholarly journals Determinants of serum polychlorinated biphenyls and organochlorine pesticides measured in women from the child health and development study cohort, 1963-1967.

2002 ◽  
Vol 110 (7) ◽  
pp. 617-624 ◽  
Author(s):  
Rebecca A James ◽  
Irva Hertz-Picciotto ◽  
Eric Willman ◽  
Jean A Keller ◽  
M Judith Charles
Keyword(s):  
Child Health ◽  
Polychlorinated Biphenyls ◽  
Organochlorine Pesticides ◽  
Study Cohort ◽  
Development Study ◽  
Health And Development

Prenatal determinants of schizophrenia: what we have learned thus far?

2005 ◽  
Vol 14 (4) ◽  
pp. 194-197 ◽  
Author(s):  
Michaeline Bresnahan ◽  
Catherine A. Schaefer ◽  
Alan S. Brown ◽  
Ezra S. Susser
Keyword(s):  
Child Health ◽  
Psychiatric Disorders ◽  
Biological Samples ◽  
Study Cohort ◽  
Prenatal Exposures ◽  
Development Study ◽  
Extensive Data ◽  
Prenatal Infection ◽  
Toxic Exposures ◽  
Health And Development

SUMMARYThe Prenatal Determinants of Schizophrenia (PDS) study was designed to examine early antecedents to schizophrenia. Based in the Child Health and Development Study cohort assembled in 1959-1967, over 12,000 cohort members were followed in the PDS study for psychiatric disorders. Using the extensive data and biological samples prospectively collected beginning during pregnancy, PDS investigators have examined the influence of prenatal exposures on risk of schizophrenia in adulthood. Here we describe a few key findings from the PDS with respect to prenatal infection, nutrition, and toxic exposures.Declaration of Interest: Supported by the Lieber Center for Schizophrenia Research, and the following grants: NIMH 1R01MH 63264-01A1 (A.S.B.), NIMH 1R01MH-60249 (A.S.B.), 1R01MH-60249-03S2 (A.S.B.), 1K02MH65422-01 (A.S.B.), aNARSAD Independent Investigator Award (A.S.B.).

scholarly journals Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: Findings from the Wirral Child Health and Development Study

2017 ◽  
Author(s):  
Elizabeth C. Braithwaite ◽  
Jonathan Hill ◽  
Andrew Pickles ◽  
Vivette Glover ◽  
Kieran O’Donnell ◽  
...  
Keyword(s):  
Birth Weight ◽  
Child Health ◽  
Fetal Growth ◽  
Gestational Age ◽  
Affective Disorders ◽  
Positive Association ◽  
Dependent Manner ◽  
Development Study ◽  
Health And Development ◽  
Infant Birth

Recent findings highlight that there are prenatal risks for affective disorders that are mediated by glucocorticoid mechanisms, and may be specific to females. There is also evidence of sex differences in prenatal programming mechanisms and developmental psychopathology, whereby effects are in opposite directions in males and females. As birth weight is a risk for affective disorders, we sought to investigate whether maternal prenatal cortisol may have sex-specific effects on fetal growth. The Wirral Child Health and Development Study (WCHADS) cohort (n=1233) included a stratified subsample (n=241) who provided maternal saliva samples, assayed for cortisol, at home over two days at 32 weeks gestation (on waking, 30-minutes post-waking, and during the evening). Measures of infant birth weight (corrected for gestational age) were taken from hospital records. General population estimates of associations between variables were obtained using inverse probability weights. Maternal log of the area under the curve (LogAUC) cortisol predicted infant birth weight in a sex-dependent manner (interaction term p=0.040). There was a positive association between maternal prenatal cortisol in males, and a negative association in females. A sex-interaction in the same direction was evident when using the waking (p=0.010), and 30-minute post waking (p=0.013) cortisol measures, but not the evening measure. There was no interaction between prenatal cortisol and sex to predict gestational age. Our findings add to an emerging body of literature that suggests that there may be sex-specific mechanisms that underpin fetal programming. Further understanding of these mechanisms is important for tailoring intervention and prevention strategies.

scholarly journals DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study

2020 ◽  
Vol 92 ◽  
pp. 138-147 ◽  
Author(s):  
Hui-Chen Wu ◽  
Barbara A. Cohn ◽  
Piera M. Cirillo ◽  
Regina M. Santella ◽  
Mary Beth Terry
Keyword(s):  
Dna Methylation ◽  
Child Health ◽  
Female Offspring ◽  
Development Study ◽  
Health And Development ◽  
Exposure During Pregnancy
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