scholarly journals The Impact of Long-Term Air Pollution Exposure on Type 1 Diabetes Mellitus-Related Mortality among U.S. Medicare Beneficiaries

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Trenton Honda ◽  
Fatemeh Kazemiparkouhi ◽  
Trenton D. Henry ◽  
Mona Elbarbary ◽  
Marcus G. Pezzolesi ◽  
...  



Diabetologia ◽  
2018 ◽  
Vol 61 (6) ◽  
pp. 1354-1361 ◽  
Author(s):  
Stefanie Lanzinger ◽  
Joachim Rosenbauer ◽  
Dorothea Sugiri ◽  
Tamara Schikowski ◽  
Birgit Treiber ◽  
...  


2021 ◽  
Vol 197 ◽  
pp. 111152
Author(s):  
Andrew D. Williams ◽  
Jenna Kanner ◽  
Katherine L. Grantz ◽  
Marion Ouidir ◽  
Shanshan Sheehy ◽  
...  


2021 ◽  
Author(s):  
Liuhua Shi ◽  
Kyle Steenland ◽  
Haomin Li ◽  
Pengfei Liu ◽  
Yuhan Zhang ◽  
...  

Abstract Epidemiological evidence suggests air pollution exposure may increase risk of Alzheimer’s disease and related dementias (ADRD). However, previous U.S. studies have predominantly focused on hospitalizations, which fails to fully capture ADRD. Here we constructed two national population-based cohorts of those aged 65 and above from the Medicare Chronic Conditions Warehouse (2000-2018), including doctor visits, to investigate the impact of long-term exposure to ambient fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) on dementia and AD incidence, respectively. We identified ~2.0 million incident dementia cases (N=12,233,371; dementia cohort) and ~0.8 million incident AD cases (N=12,456,447; AD cohort). Per interquartile range (IQR) increase in the 5-year average PM2.5 (3.2 µg/m3), NO2 (11.6 ppb), and warm-season O3 (5.3 ppb) over the past 5 years prior to diagnosis, the hazard ratios (HRs) were 1.060 (95% confidence interval [CI]: 1.054, 1.066), 1.019 (95% CI: 1.012, 1.026), and 0.990 (95% CI: 0.987, 0.993) for incident dementias, and 1.078 (95% CI: 1.070, 1.086), 1.031 (95% CI: 1.023, 1.039), and 0.982 (95%CI: 0.977, 0.986) for incident AD, respectively, for the three pollutants. For both outcomes there was strong evidence of linearity in concentration-response relationships for PM2.5 and NO2, suggesting the lack of a clear safe threshold for these health-harmful pollutants. Our study suggests that exposures to PM2.5 and NO2, but not O3, may increase the incidence of dementia and AD. Improving air quality may reduce the burden of ADRD and promote healthy aging.



Author(s):  
Martín Borja Sanz ◽  
Gimeno Sergio Roman ◽  
Peteiro Miranda Carlos Miguel ◽  
Ortez Toro Jose Jorge ◽  
Ana Agudo ◽  
...  


Author(s):  
Larisa Dmitrievna Popovich ◽  
Svetlana Valentinovna Svetlichnaya ◽  
Aleksandr Alekseevich Moiseev

Diabetes – a disease in which the effect of the treatment substantially depends on the patient. Known a study showed that the use of glucometers with the technology of three-color display of test results facilitates self-monitoring of blood sugar and leads to a decrease in glycated hemoglobin (HbAlc). Purpose of the study: to modeling the impact of using of a glucometer with a color-coded display on the clinical outcomes of diabetes mellitus and calculating, the potential economic benefits of reducing the hospitalization rate of patients with diabetes. Material and methods. Based on data from two studies (O. Schnell et al. and M. Baxter et al.) simulation of the reduction in the number of complications with the use of a glucometer with a color indication. In a study by O. Schnell et al. a decrease of HbA1c by 0.69 percent is shown when using the considered type of glucometers, which was the basis of the model. Results. In the model, the use of a glucometer with a color-coded display for type 1 diabetes led to a decrease in the total number of complications by 9.2 thousand over 5 years per a cohort of 40 thousand patients with different initial levels of HbA1c. In a cohort of 40 thousand patients with type 2 diabetes, the simulated number of prevented complications was 1.7 thousand over 5 years. When extrapolating these data to all patients with diabetes included in the federal register of diabetes mellitus (FRD), the number of prevented complications was 55.4 thousand cases for type 1 diabetes and 67.1 thousand cases for type 2 diabetes. The possible economic effect from the use of the device by all patients with a diagnosis of diabetes, which are included in the FRD, estimated at 1.5 billion rubles for a cohort of patients with type 1 diabetes and 5.3 billion rubles for patients with type 2 diabetes. Conclusion. Improving the effectiveness of self-monitoring, which is the result of the use of glucometers with color indicators, can potentially significantly reduce the incidence of complications in diabetes and thereby provide significant economic benefits to society.



2001 ◽  
Vol 131 (6) ◽  
pp. 1723-1730 ◽  
Author(s):  
Begoña Manuel y Keenoy ◽  
Honglei Shen ◽  
Wendy Engelen ◽  
Jan Vertommen ◽  
Guido Van Dessel ◽  
...  




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