scholarly journals A Young Woman with Fever and Cervical Lymphadenopathy

2015 ◽  
Vol 2 (6) ◽  
Author(s):  
Aída Gil-Díaz ◽  
Raju Daryanani-Daryanani ◽  
Rafael Estevez-Dominguez ◽  
Jose Gil-Reyes ◽  
Carlos Santana-Perez
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Young Woman ◽  
Connective Tissue Diseases ◽  
Cervical Lymphadenopathy ◽  
Rare Disorder ◽  
Unknown Aetiology ◽  
Antiinflammatory Agents ◽  
Night Sweats

Kikuchi-Fujimoto's disease is a self-limiting and rare disorder of unknown aetiology. The typical presentation includes fever, cervical lymphadenopathy and night sweats. Consequently, it is part of the differential diagnosis of infectious, lymphoproliferative and connective tissue diseases. Histology demonstrates necrotizing histiocytic lymphadenitis. Treatment is symptomatic with non-steroidal antiinflammatory agents, although there are reports of corticosteroid use in complicated cases. We present the case of a 23-year-old woman admitted to hospital for fever and cervical lymphadenopathies, and diagnosed with Kikuchi-Fujimoto's disease.

Idiopathic Inflammatory Myopathies

2015 ◽  
Author(s):  
Frederick W Miller ◽  
Adam Schiffenbauer
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Clinical Laboratory ◽  
Connective Tissue Diseases ◽  
Muscle Pathology ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Pathologic Evaluation

The idiopathic inflammatory myopathies (IIMs), also known as myositis syndromes, are a collection of heterogeneous disorders that share the common feature of chronic muscle inflammation of unknown cause. These disorders may occur in adults or children and are sometimes associated with other connective tissue disorders and a variety of cancers. A combined clinical, laboratory, and pathologic evaluation is needed to establish the diagnosis of these acquired systemic connective tissue diseases to rule out the many disorders that mimic IIMs. This module reviews the classification of IIMs, including polymyositis, dermatomyositis, inclusion body myositis, myositis associated with other connective tissue diseases and cancer, and antisynthetase syndrome. The epidemiology; etiology, genetics, and environmental factors; pathophysiology and pathogenesis; diagnosis; differential diagnosis; treatment; and prognosis of IIMs are discussed. Tables describe the criteria for polymyositis, dermatomyositis, and inclusion body myositis; well-characterized subgroups of the IIMs in adults and children; presentation of polymyositis; differential diagnosis of muscle weakness or pain; features that assist in discriminating IIMs from other myopathies; goals for managing IIMs; and key factors for achieving adequate corticosteroid response in IIMs. Figures demonstrate skin findings in IIMs, muscle pathology of IIMs, magnetic resonance imaging of three patients with different IIMs, and treatment approaches to the management of myositis patients. This review contains 4 highly rendered figures, 8 tables, and 80 references.

scholarly journals Diffuse Calcifications of the Spleen in a Woman with Systemic Lupus Erythematosus

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Aristeides G. Vaiopoulos ◽  
Meletios A. Kanakis ◽  
Kyriaki Katsouri ◽  
Stavroula Kyriazi ◽  
George A. Vaiopoulos ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Spontaneous Rupture ◽  
Connective Tissue Diseases ◽  
Systemic Lupus ◽  
Unique Pattern ◽  
Splenic Involvement

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, which affects a wide variety of organs including the spleen. Splenic involvement in SLE includes conditions such as splenomegaly, hyposplenism, infarction, and spontaneous rupture. However, only a few cases of splenic calcifications in patients with SLE have been reported. Herein, we present a case of a 24-year-old female diagnosed with SLE, in which we found diffuse splenic calcifications. The unique pattern of splenic calcifications in SLE contributes to the differential diagnosis from other conditions such as infections and other connective tissue diseases, which also cause calcifications in the spleen.

scholarly journals Facial erythromelalgia: A rare entity to consider in the differential diagnosis of connective tissue diseases

2014 ◽  
Vol 71 (6) ◽  
pp. e250-e251 ◽  
Author(s):  
Mital Patel ◽  
Alisa N. Femia ◽  
A. Brooke Eastham ◽  
Janice Lin ◽  
Alvaro Laga Canales ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Rare Entity

A RARE CASE OF ROSAI-DORFMAN DISEASE IN HYPOTHYROIDISM PATIENT A DIAGNOSTIC COEXISTENCE

2021 ◽  
pp. 31-32
Author(s):  
Gridhati Srinivas ◽  
Tarun Kumar Dutta
Keyword(s):  
Weight Loss ◽  
Differential Diagnosis ◽  
Soft Tissue ◽  
Rare Case ◽  
Cervical Lymphadenopathy ◽  
Nodal Involvement ◽  
Nodal Disease ◽  
Rosai Dorfman Disease ◽  
Night Sweats ◽  
Rule Out

Rosai-Dorfman disease (RDD) is a rare, benign, and predominantly nodal disease that most commonly presents as bilateral, painless cervical lymphadenopathy; although inguinal, axillary, mediastinal, and hilar lymphadenopathy has also been reported. Apart from nodal involvement, RDD has extra nodal manifestations involving bone, soft tissue, and liver as well as constitutional symptoms of fever, night sweats, and weight loss, which make it reasonable to rule out the infectious, autoimmune, and malignant conditions as the differential diagnosis.

Idiopathic Inflammatory Myopathies

2015 ◽  
Author(s):  
Frederick W Miller ◽  
Adam Schiffenbauer
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Clinical Laboratory ◽  
Connective Tissue Diseases ◽  
Muscle Pathology ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Pathologic Evaluation

The idiopathic inflammatory myopathies (IIMs), also known as myositis syndromes, are a collection of heterogeneous disorders that share the common feature of chronic muscle inflammation of unknown cause. These disorders may occur in adults or children and are sometimes associated with other connective tissue disorders and a variety of cancers. A combined clinical, laboratory, and pathologic evaluation is needed to establish the diagnosis of these acquired systemic connective tissue diseases to rule out the many disorders that mimic IIMs. This module reviews the classification of IIMs, including polymyositis, dermatomyositis, inclusion body myositis, myositis associated with other connective tissue diseases and cancer, and antisynthetase syndrome. The epidemiology; etiology, genetics, and environmental factors; pathophysiology and pathogenesis; diagnosis; differential diagnosis; treatment; and prognosis of IIMs are discussed. Tables describe the criteria for polymyositis, dermatomyositis, and inclusion body myositis; well-characterized subgroups of the IIMs in adults and children; presentation of polymyositis; differential diagnosis of muscle weakness or pain; features that assist in discriminating IIMs from other myopathies; goals for managing IIMs; and key factors for achieving adequate corticosteroid response in IIMs. Figures demonstrate skin findings in IIMs, muscle pathology of IIMs, magnetic resonance imaging of three patients with different IIMs, and treatment approaches to the management of myositis patients. This review contains 4 highly rendered figures, 8 tables, and 80 references.

scholarly journals Histopathology of the muscle in rheumatic diseases

Reumatismo ◽  
2018 ◽  
pp. 133-145 ◽  
Author(s):  
S. Barsotti ◽  
A. Tripoli ◽  
L.E. Pollina ◽  
M. Mosca ◽  
R. Neri
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Connective Tissue ◽  
Rheumatic Diseases ◽  
Critical Analysis ◽  
Medical Literature ◽  
Connective Tissue Diseases ◽  
Current Medical ◽  
Pathology Report ◽  
Drug Induced

The presence of muscular symptoms is common in rheumatological clinical practice, but often the differential diagnosis between muscular involvement in connective tissue diseases, vasculitis and drug-induced myopathy may be difficult. In addition to clinical assessment, laboratory analysis and instrumental examinations, muscle biopsy may help to clarify the diagnosis in patients with muscular involvement. The purpose of this review is to provide a critical analysis of the current medical literature on muscular histopathology, to help clinicians to identify when to perform muscular biopsy and to provide a practical guide to a better understanding of the pathology report. Moreover, we provide an overview of the muscular involvement and the most common histopathological findings in rheumatic diseases.

Oral focal mucinosis of the palate: a rare disease entity

2020 ◽  
Vol 13 (3) ◽  
pp. e230233
Author(s):  
Alice Cameron ◽  
James Edward Noctun Webster ◽  
Catherine Elizabeth Wicks ◽  
Serryth Dominic Colbert
Keyword(s):  
Differential Diagnosis ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Connective Tissue ◽  
Histological Analysis ◽  
Rare Condition ◽  
Disease Entity ◽  
Unknown Aetiology ◽  
Myxoid Degeneration ◽  
Oral Soft Tissue

Oral focal mucinosis (OFM) is an extremely rare, benign oral soft tissue condition; less than 10 documented cases have been reported in the literature in patients under 18 years old. OFM has an unknown aetiology and predominantly presents in the fourth and fifth decades. The pathogenesis of OFM may be due to fibroblast overproduction of hyaluronic acid. Clinically, it remains almost impossible to diagnose definitively, due to its lack of pathognomonic features, therefore such lesions may have multiple differential diagnoses and histological analysis is essential to confirm OFM. We present an unusual presentation of OFM in a 14-year-old female patient. Following excision, focal myxoid degeneration of the connective tissue was apparent. This case highlights this rare condition for consideration in differential diagnosis of clinically similar lesions.

Sign in / Sign up

Export Citation Format

Share Document