scholarly journals Histopathology of the muscle in rheumatic diseases

Reumatismo ◽  
2018 ◽  
pp. 133-145 ◽  
Author(s):  
S. Barsotti ◽  
A. Tripoli ◽  
L.E. Pollina ◽  
M. Mosca ◽  
R. Neri
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Connective Tissue ◽  
Rheumatic Diseases ◽  
Critical Analysis ◽  
Medical Literature ◽  
Connective Tissue Diseases ◽  
Current Medical ◽  
Pathology Report ◽  
Drug Induced

The presence of muscular symptoms is common in rheumatological clinical practice, but often the differential diagnosis between muscular involvement in connective tissue diseases, vasculitis and drug-induced myopathy may be difficult. In addition to clinical assessment, laboratory analysis and instrumental examinations, muscle biopsy may help to clarify the diagnosis in patients with muscular involvement. The purpose of this review is to provide a critical analysis of the current medical literature on muscular histopathology, to help clinicians to identify when to perform muscular biopsy and to provide a practical guide to a better understanding of the pathology report. Moreover, we provide an overview of the muscular involvement and the most common histopathological findings in rheumatic diseases.

THE IMPORTANCE OF ANTIPHOSPHOLIPID SYNDROME IN DEVELOPED CEREBROVASCULAR DISEASES ON THE BACKGROUND OF SYSTEMATIC CONNECTIVE TISSUE DISEASES

2021 ◽  
Vol 2 (1) ◽  
pp. 9-13
Author(s):  
O. Ya. Bustanov ◽  
◽  
Yu. N. Madjidova ◽  
N. A. Nasirdinova ◽  
O. B. Kuchkarova ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Early Diagnosis ◽  
Antiphospholipid Syndrome ◽  
Rheumatic Diseases ◽  
Cerebrovascular Disorders ◽  
Connective Tissue Diseases ◽  
Modern Medicine ◽  
Cerebrovascular Diseases ◽  
Diagnostic Methods

The article developed criteria for early diagnosis of cerebrovascular disorders, one of the complications of antiphospholipid syndrome in patients with systemic connective tissue, and proposed diagnostic methods to prevent this process’s exacerbationand developsevere irreversible complications. This will help stop the development of antiphospholipid syndrome from the urgent problems of modern medicine and manage the effectiveness of treatmentand improve patients’quality of life.Keywords:cerebrovascular pathology, rheumatic diseases, antiphospholipid syndrome, anticardiolipid antibodies

scholarly journals Clinical practice guidelines adherence, knowledge and awareness in rare and complex connective tissue diseases across Europe: results from the first ERN ReCONNET survey

RMD Open ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. e001344
Author(s):  
Rosaria Talarico ◽  
Diana Marinello ◽  
Stefano Bombardieri ◽  
Gerd Burmester ◽  
Joao Fonseca ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Connective Tissue ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Healthcare Professionals ◽  
Musculoskeletal Diseases ◽  
Family Members ◽  
Disease Patient ◽  
Connective Tissue Diseases ◽  
Reference Network

IntroductionThe European Reference Network (ERN) ReCONNET is the ERN aimed at improving the management of rare and complex connective tissue and musculoskeletal diseases (rCTDs) across the European Union (EU). In the mission of ERN ReCONNET, clinical practice guidelines (CPGs) play a crucial role, representing a valid tool towards the harmonisation of the management of rCTDs while improving effectiveness and quality of care delivered to patients.MethodsERN ReCONNET developed two surveys to map the adherence to rCTDs CPGs among healthcare providers and to assess the knowledge and awareness of CPGs for their diseases among patients, family members and caregivers.ResultsThe results of the surveys highlighted that healthcare professionals find it useful to apply CPGs in clinical practice (93%), while 62% of them experience difficulties and barriers in the application in their centres. Healthcare professionals also highlighted the need to develop CPGs for all rCTDs and to implement the use of the existing CPGs in clinical practice. On the other hand, patients, families and caregivers are relatively aware of the purpose of CPGs (51%) and 62% of them were aware of the existence of CPGs for their disease. Patient-friendly versions of CPGs and patients’ lifestyle guidelines should be systematically developed contributing to the empowerment of patients in the disease management.ConclusionERN ReCONNET is addressing the main issues identified in the results of the survey, promoting practical actions for the local adaptation of CPGs across Europe, improving their routine clinical use and increasing the awareness on CPGs among rCTDs patients, family members and caregivers.

scholarly journals Undifferentiated connective tissue disease: state of the art on clinical practice guidelines

RMD Open ◽  
2019 ◽  
Vol 4 (Suppl 1) ◽  
pp. e000786 ◽  
Author(s):  
Margarida Antunes ◽  
Carlo Alberto Scirè ◽  
Rosaria Talarico ◽  
Tobias Alexander ◽  
Tadej Avcin ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Connective Tissue Diseases ◽  
Preventive Measure ◽  
Undifferentiated Connective Tissue Disease ◽  
Consensus Definition ◽  
Severe Condition

The term ‘undifferentiated connective tissue disease’ (UCTD) is generally used to describe clinical entities characterised by clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for defined connective tissue diseases (CTDs). In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the ERN ReCONNET project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations.No specific CPG on UCTD were found, potential areas of intervention are absence of a consensus definition of UCTD, need for specific monitoring and therapeutic protocols, stratification of UCTD based on the risk of developing a defined CTD and preventive measure for the future development of a more severe condition.Patients feel uncertainty regarding the name of the disease and feel the need of a better education and understanding of these conditions and its possible changes over time.

Diagnosis of diseases: principles and clinical practice

2020 ◽  
Author(s):  
Alexander Dreval
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Medical Students ◽  
Medical Literature ◽  
Educational Literature ◽  
Clinical Culture ◽  
Basic Concepts ◽  
Diagnosis Of Diseases ◽  
Real Clinical Practice

The manual presents General principles of diagnosis of diseases that have not yet been discussed in detail in the educational literature. The book provides algorithms for selecting diagnostic hypotheses, explains the basic concepts that are ambiguously interpreted in the medical literature. The manual will make it easier for senior medical students, clinical residents and novice doctors to learn the fundamental principles of differential diagnosis. The book will help them become excellent specialists with a high General clinical culture and effectively apply their knowledge in real clinical practice.

scholarly journals Nailfold Capillaroscopy in Rheumatic Diseases

2020 ◽  
Author(s):  
Abhishek Patil ◽  
Isha Sood
Keyword(s):  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Early Diagnosis ◽  
Rheumatic Diseases ◽  
Connective Tissue Diseases ◽  
Nailfold Capillaroscopy ◽  
Indispensable Tool

Nailfold capillaroscopy (NFC) has developed into an indispensable tool for rheumatologists in the evaluation of rheumatic diseases. It offers various advantages in being rapid, noninvasive, and inexpensive. With NFC we are able to visualize the microcirculatory changes in the nail beds. These changes are key to the pathogenesis of connective tissue diseases such as systemic sclerosis. Hence NFC helps in early diagnosis of various connective tissue diseases. There is a lack of standardization in the techniques used and various capillary parameters studied, which could lead to variation in the reporting of the parameters studied. In this chapter we shall try to highlight the most common parameters studied in capillaroscopy and its utility in various connective tissue diseases.

scholarly journals Anti-TIF-1γ Antibody Detection Using a Commercial Kit vs In-House Immunoblot: Usefulness in Clinical Practice

2021 ◽  
Vol 11 ◽  
Author(s):  
Anaís Mariscal ◽  
Milena Milán ◽  
Andrés Baucells ◽  
Maria Angeles Martínez ◽  
Andrea Garcia Guillen ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Connective Tissue ◽  
Gold Standard ◽  
Connective Tissue Diseases ◽  
Antibody Detection ◽  
Immunoblot Assay ◽  
High Prevalence ◽  
Autoantibody Detection ◽  
Undifferentiated Connective Tissue Diseases ◽  
Commercial Kit

ObjectivesAnti-TIF-1γ autoantibody detection is important for cancer screening in patients with dermatomyositis. The gold standard for anti-TIF-1γ detection, immunoprecipitation, is only available from a few specialized laboratories worldwide, so commercial ELISA/immunoblot tests have emerged in recent years. To analyze their usefulness in diagnosing cancer-associated dermatomyositis, we compared Euroimmun Euroline profile with our previously validated in-house immunoblot assay with human recombinant TIF-1γ.MethodsWe included 308 adult patients from Hospital de la Santa Creu I Sant Pau and Vall Hebrón Hospital (Barcelona, Spain) tested for anti-TIF-1γ autoantibodies using the Euroline profile and an in-house immunoblot assay.ResultsA total of 27 anti-TIF-1γ were detected by the Euroline and 12 by the in-house assay. Fair agreement was observed between Euroline and the in-house immunoblot Cohen’s kappa 0.3163. Expected prevalence of anti-TIF-1γ autoantibodies was observed for the two methods for dermatomyositis and undifferentiated connective tissue diseases, but unexpectedly high prevalence of anti-TIF-1γ autoantibodies was detected by Euroline compared to the in-house immunoblot for other diseases (16.5% Euroline vs 0.8% in-house immunoblot, p<0.01). The in-house IB compared to Euroline more reliably detected cancer in patients with DM with anti-TIF-1γ antibodies (p=0.0014 vs p=0.0502 for in-house immunoblot vs Euroline).ConclusionWe recommend using a second validated method to confirm Euroline-detected anti-TIF-1γ antibodies when the dermatomyositis diagnosis is not definitive. Furthermore, in the context of definite DM diagnosis with negative anti-TIF-1γ antibodies by Euroline and no other myositis specific antibody, is also recommendable to confirm by a second validated method.

Idiopathic Inflammatory Myopathies

2015 ◽  
Author(s):  
Frederick W Miller ◽  
Adam Schiffenbauer
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Clinical Laboratory ◽  
Connective Tissue Diseases ◽  
Muscle Pathology ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Pathologic Evaluation

The idiopathic inflammatory myopathies (IIMs), also known as myositis syndromes, are a collection of heterogeneous disorders that share the common feature of chronic muscle inflammation of unknown cause. These disorders may occur in adults or children and are sometimes associated with other connective tissue disorders and a variety of cancers. A combined clinical, laboratory, and pathologic evaluation is needed to establish the diagnosis of these acquired systemic connective tissue diseases to rule out the many disorders that mimic IIMs. This module reviews the classification of IIMs, including polymyositis, dermatomyositis, inclusion body myositis, myositis associated with other connective tissue diseases and cancer, and antisynthetase syndrome. The epidemiology; etiology, genetics, and environmental factors; pathophysiology and pathogenesis; diagnosis; differential diagnosis; treatment; and prognosis of IIMs are discussed. Tables describe the criteria for polymyositis, dermatomyositis, and inclusion body myositis; well-characterized subgroups of the IIMs in adults and children; presentation of polymyositis; differential diagnosis of muscle weakness or pain; features that assist in discriminating IIMs from other myopathies; goals for managing IIMs; and key factors for achieving adequate corticosteroid response in IIMs. Figures demonstrate skin findings in IIMs, muscle pathology of IIMs, magnetic resonance imaging of three patients with different IIMs, and treatment approaches to the management of myositis patients. This review contains 4 highly rendered figures, 8 tables, and 80 references.

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