scholarly journals Ethyl Pyruvate Downregulates Tumor Necrosis Factor Alpha and Interleukin (IL)-6 and Upregulates IL-10 in Lipopolysaccharide-Stimulated Canine Peripheral Blood Mononuclear Cells

2010 ◽  
Vol 72 (10) ◽  
pp. 1379-1381 ◽  
Author(s):  
Do-Hyeon YU ◽  
Dong-Ho NOH ◽  
Ru-Hui SONG ◽  
Jinho PARK
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Mononuclear Cells ◽  
Ethyl Pyruvate ◽  
Peripheral Blood Mononuclear ◽  
Necrosis Factor Alpha ◽  
Blood Mononuclear Cells ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals The Treponema denticola Surface Protease Dentilisin Degrades Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor Alpha

2006 ◽  
Vol 74 (4) ◽  
pp. 2462-2467 ◽  
Author(s):  
Meguru Miyamoto ◽  
Kazuyuki Ishihara ◽  
Katsuji Okuda
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Mononuclear Cells ◽  
Interleukin 1Β ◽  
Treponema Denticola ◽  
Peripheral Blood Mononuclear ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.

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