Screening of Wound Healing Activity of a Polyherbal Formulation

Objective: The present study describes the anti-microbial acivity of Acacia arabica and Butea monosperma bark extract.Methods: For this purpose aqueous extract of bark were prepared by “Soxhlet extraction method”. The experimentally induced burn wound model in rats by “Excision method”.Results: As a result of this study it was found that the extract of bark generally revealed antimicrobial and wound healing activity.Conclusion: The result of the study suggest that the Acacia arabica and Butea monosperma bark of polyherbal gel effective in accelerating wound healing process.

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Antimicrobial, anti-inflammatory and wound healing activity of polyherbal formulation

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2018.12.075 ◽

2019 ◽

Vol 111 ◽

pp. 555-567 ◽

Cited By ~ 12

Author(s):

Suresh Kumar Dev ◽

P.K. Choudhury ◽

Rajnish Srivastava ◽

Maya Sharma

Keyword(s):

Wound Healing ◽

Polyherbal Formulation ◽

Anti Inflammatory ◽

Wound Healing Activity

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Evaluation of polyherbal ointment for wound healing activity in Wistar rats

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i6-s.2072 ◽

2018 ◽

Vol 8 (6-s) ◽

pp. 26-31

Author(s):

Shilpa S. Kolhe

Keyword(s):

Wound Healing ◽

Wistar Rats ◽

Breaking Strength ◽

Skin Irritation ◽

Wound Contraction ◽

Alcoholic Extract ◽

Polyherbal Formulation ◽

Wound Healing Activity

The aim of present study to formulate, evaluate and to check the wound healing activity of newly prepared polyherbal formulation (ointment) .Herbal ointment containing hydrochloric extracts of plants Psorolea corylifalia, Achryanthes aspera ,was formulated as ointment and the hydro alcoholic extract was prepared by maceration method. These Formulations were evaluated for the following parameters: pH, Spread ability, grittiness, skin irritation study, stability. The wound healing activity is assessed by the rate of wound contraction, Period of epithelisation and skin breaking strength. Keywords: Herbal Ointment, Wound Healing Activity.

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WOUND HEALING ACTIVITY OF AERIAL PARTS OF EUPHORBIA HIRTA LINN. AND ITS POLYHERBAL FORMULATION

INDIAN DRUGS ◽

10.53879/id.57.07.12258 ◽

2020 ◽

Vol 57 (07) ◽

pp. 58-62

Author(s):

Pushpendra Kumar Jain ◽

Yogesh Pounikar ◽

Navneet Khurana

Keyword(s):

Wound Healing ◽

Ethanolic Extract ◽

Albino Rats ◽

Euphorbia Hirta ◽

Polyherbal Formulation ◽

Aerial Parts ◽

Tridax Procumbens ◽

Histopathological Studies ◽

Wound Healing Activity

This study was undertaken to investigate the in vivo wound healing activity of ethanol extracts of the aerial parts of Euphorbia hirta Linn. and its polyherbal formulation with Tridax procumbens and Eclipta alba. The in vivo wound healing activity was assessed in albino rats by using three wound models i.e. excision wound, incision wound and dead space wound models. Level of biochemical markers and histological changes were monitored to evaluate the enhancement of wound healing. The results showed that ethanolic extract ointment possesses a definite prohealing action. This was demonstrated by a significant increase in the rate of wound contraction and by enhanced epithelization. Significant increase in tensile strength, hydroxyproline content and collagen levels were observed, which was further supported by histopathological studies and gain in granuloma breaking strength.

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Pharmacological evaluation of wound healing activity of herbal based formulation “Amree Plus®” in diabetic rats

The Journal of Phytopharmacology ◽

10.31254/phyto.2017.6101 ◽

2017 ◽

Vol 6 (1) ◽

pp. 1-10

Author(s):

Sunita Thakur ◽

◽

Isha Dhamija ◽

Sandeep Kumar ◽

Anil Kumar Sharma ◽

...

Keyword(s):

Wound Healing ◽

Diabetic Rats ◽

Proline Content ◽

Wound Contraction ◽

Total Protein Content ◽

Delayed Wound Healing ◽

Polyherbal Formulation ◽

Wound Model ◽

Herbal Formulation ◽

Wound Healing Activity

Delayed wound healing is producing high economic burden on the society and is generally associated with Diabetes mellitus or related complications thus needs safe treatment like herbal formulation. „Amree Plus® (an anti-diabetic ayurvedic formulation)‟ was evaluated for wound healing potential in normal and diabetic rats. The effect of polyherbal formulation Amree plus ® on wound healing has been studied in diabetic and normal animals and compared with standard (Chymoral Forte) using excision wound model. Diabetes was induced by administration of single dose of Streptozotocin 55 mg/kg i.p. The biochemical parameters i.e. hydroxyl proline content, total protein content, glutathione and superoxide dismutase (SOD) were also estimated. Rats treated with Amree Plus® at both doses i.e. 1200 and 5400 mg/kg dose per day had significantly high wound contraction both in diabetic and normal rats (88.91 & 95.05 %, respectively) in comparison to respective control. Hydroxyproline content of the granulation tissue and anti-oxidants (glutathione and SOD) level were also showing same pattern in Amree Plus® 5400 mg/kg treatment group with respect to controls. Wound contraction and other biochemical indicators results with animals Amree Plus® (1200 mg/kg) treated were found to be statistically equivalent to standard chymoral forte dose (36 kAU/kg) while Amree Plus® 5400 mg/kg dose showed statistically higher results than standard. Amree Plus®, an established antidiabetic formulation, was also showing healing of the wound in normal animals along with diabetic animals. So this finding should be confirmed further for more precision with large number of animals and small progression of doses.

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