Local Application of Combined Natural Essential Oils for Pain Relief after Elective Throat Surgery in the Early Postoperative Period

2021 ◽  
Vol 9 (1) ◽  
pp. 09-15
Author(s):  
Diāna Katoviča ◽  
◽  
Gunta Sumeraga ◽  
Marks Ronis
Keyword(s):  
Pain Relief ◽  
Essential Oils ◽  
Postoperative Period ◽  
Early Postoperative Period ◽  
Local Application

Local application of combined natural essential oils for pain relief after elective throat surgery in the early postoperative period

2021 ◽  
Vol 20 (4) ◽  
pp. 96-101
Author(s):  
M. Ronis ◽  
◽  
D. Katovich ◽  
G. Sumeraga ◽  
◽  
...  
Keyword(s):  
Pain Relief ◽  
Essential Oils ◽  
Postoperative Period ◽  
Study Drug ◽  
Early Postoperative Period ◽  
Upper Respiratory Tract ◽  
Inflammatory Drugs ◽  
Upper Respiratory ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Tonsillectomy, cryptolysis of the palatine tonsils, and removal of various formations in the pharyngeal region are the most common elective operations in otorhinolaryngology. Pain in the early postoperative period is still the most frequent complication after these procedures, which can adversely affect the patient’s daily life. Considering the potential analgesic and anti-inflammatory effect of essential oil preparations, as well as their ability to be easily applied locally to the affected mucosal surface, it is worth considering their use to reduce pain and dysphagia in the postoperative period in the upper respiratory tract. The study involved 77 patients who were randomly divided into 2 groups: patients taking a drug containing combined natural essential oils (CNEO) and patients taking a placebo. In the course of the study, a questionnaire was used, according to which patients were interviewed immediately after the operation, then on the 3rd and 10th postoperative days. The results of the study show that the drug does not directly reduce postoperative pain in the pharynx, but in patients in the group with the drug based on combined essential oils, the frequency of taking non-steroidal anti-inflammatory drugs (NSAIDs) was less than in patients in the placebo group, which indirectly proves the effectiveness of the drug based on combined essential oils. Given the fact that the frequency of NSAID use is lower in the CPNEM group, it can be assumed that the study drug reduces the risk of side effects caused by NSAID use, and can also be an alternative method of pain relief for patients who are contraindicated in NSAIDs.

scholarly journals OPRM1 and ABCB1 Polymorphisms and Their Effect on Postoperative Pain Relief With Piritramide

2015 ◽  
pp. S521-S527 ◽  
Author(s):  
O. BARTOŠOVÁ ◽  
O. POLANECKÝ ◽  
F. PERLÍK ◽  
S. ADÁMEK ◽  
O. SLANAŘ
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Adverse Effects ◽  
Postoperative Period ◽  
Receptor Gene ◽  
Early Postoperative Period ◽  
Postoperative Pain Relief ◽  
Intensity Difference ◽  
Pain Intensity Difference ◽  
118G Allele

Genetic factors may contribute to the differential response to opioids. The aim of this study was to evaluate the association between polymorphisms of µ1-opioid receptor gene OPRM1 (rs1799971), and P-glycoprotein transporter gene ABCB1 (rs1045642, rs2032582), and piritramide efficacy under postoperative patient-controlled analgesia (PCA). In 51 patients, OPRM1 variant was associated with decreased efficacy in early postoperative period evidenced by sum of pain intensity difference in the 0-6 h postoperative period (SPID0-6), (F=3.27, p=0.029). Mean (SD) SPID0-6 was observed in the 118AA genotype 22.9 (6.1) mm, which was significantly higher from the 118GG genotype 10.0 (4.4) mm, p=0.006. The lowest cumulative dose was recorded in 118AA genotype 19.1 (9.8) mg, which was significantly less than in the 118GG genotype group 36.6 (6.1) mg, p=0.017. Opioid–induced adverse effects were observed in 11, 30, and 100 % of patients in 118AA, 118AG, and 118GG genotype groups, respectively (p<0.05). Piritramide efficacy and safety was not significantly affected by ABCB1 (rs1045642, rs2032582) polymorphisms. Variant OPRM1 118G allele is associated with decreased acute postoperative pain relief after piritramide. Decreased efficacy leads to higher drug consumption under PCA settings, which however, does not fully compensate insufficient pain relief, but increases incidence of adverse effects.

scholarly journals Efficiency and safety of pharmacotherapy for postoperative pain in cardiac surgery

2021 ◽  
Vol 20 (3) ◽  
pp. 2683
Author(s):  
D. A. Sychev ◽  
T. E. Morozova ◽  
D. A. Shatskiy ◽  
E. V. Shikh
Keyword(s):  
Cardiac Surgery ◽  
Postoperative Pain ◽  
Pain Relief ◽  
Postoperative Period ◽  
Multimodal Analgesia ◽  
Early Postoperative Period ◽  
Current Review ◽  
Negative Effect ◽  
Safe Technique

Intraoperative injury with the formation of a sternotomy wound is inevitably accompanied by postoperative pain, which has a negative effect on the postoperative period and prognosis of patients. Today, moderate and severe pain affects at least half of patients in the early postoperative period after cardiac surgery. Inadequate pain relief in the early postoperative period can lead to chronic pain, which significantly reduces the quality of life of patients. The concept of multimodal analgesia with different painkillers is a priority, effective and safe technique both after cardiac surgery and in other areas of surgery. The current review article is devoted to the analysis of efficacy and safety of various drug groups for postoperative pain relief in cardiac surgery.

scholarly journals Recovery of early postoperative muscle strength after deep neuromuscular block by means of ultrasonography with comparison of neostigmine versus sugammadex as reversal drugs: study protocol for a randomised controlled trial

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e043935
Author(s):  
Xuan Wang ◽  
Yingyuan Li ◽  
Chanyan Huang ◽  
Wei Xiong ◽  
Qin Zhou ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Muscle Strength ◽  
Neuromuscular Blockade ◽  
Postoperative Period ◽  
Controlled Trial ◽  
Complete Recovery ◽  
Early Postoperative Period ◽  
Time Points ◽  
Muscle Groups ◽  
Randomised Controlled

IntroductionDespite the use of quantitative neuromuscular monitoring together with the administration of reversal drugs (neostigmine or sugammadex), the incidence of residual neuromuscular blockade defined as a train-of-four ratio (TOFr) <0.9 remains high. Even TOFr >0.9 cannot ensure adequate recovery of neuromuscular function when T1 height is not recovered completely. Thus, a mathematical correction of TOFr needs to be applied because the return of a normal TOFr can precede the return of a normal T1 twitch height. On the other hand, different muscles have different sensitivities to neuromuscular blockade agents; thus, complete recovery of one specific muscle group does not represent complete recovery of all other muscles. Therefore, our study aims to assess the muscle strength recovery of respiratory-related muscle groups by ultrasound and evaluate global strength using handgrip dynamometry in the early postoperative period when TOFr=0.9 and corrected TOFr (cTOFr)=0.9 with comparison of neostigmine versus sugammadex as reversal drugs.Methods and analysisThis study will be a prospective, single-blinded, randomised controlled trial involving 60 patients with American Society of Anesthesiologists physical status I–II and aged between 18 and 65 years, who will undergo microlaryngeal surgery. We will assess geniohyoid muscle, parasternal intercostal muscle, diaphragm, abdominal wall muscle and handgrip strength at four time points: before anaesthesia, TOFr=0.9, cTOFr=0.9 and 30 min after admission to the post anaesthesia care unit. Our primary objective will be to compare the effects of neostigmine and sugammadex on the recovery of muscle strength of different muscle groups in the early postoperative period when TOFr=0.9 and cTOFr=0.9. The secondary objective will be to observe the difference of muscle strength between the time points of TOFr=0.9 and cTOFr=0.9 to find out the clinical significance of cTOFr >0.9.Ethics and disseminationThe protocol was reviewed and approved by the Ethics Committee of The First Affiliated Hospital, Sun Yat-sen University. The findings will be disseminated to the public through peer-reviewed scientific journals.Trial registration numberChiCTR2000033832.

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