Local application of combined natural essential oils for pain relief after elective throat surgery in the early postoperative period

2021 ◽  
Vol 20 (4) ◽  
pp. 96-101
Author(s):  
M. Ronis ◽  
◽  
D. Katovich ◽  
G. Sumeraga ◽  
◽  
...  
Keyword(s):  
Pain Relief ◽  
Essential Oils ◽  
Postoperative Period ◽  
Study Drug ◽  
Early Postoperative Period ◽  
Upper Respiratory Tract ◽  
Inflammatory Drugs ◽  
Upper Respiratory ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Tonsillectomy, cryptolysis of the palatine tonsils, and removal of various formations in the pharyngeal region are the most common elective operations in otorhinolaryngology. Pain in the early postoperative period is still the most frequent complication after these procedures, which can adversely affect the patient’s daily life. Considering the potential analgesic and anti-inflammatory effect of essential oil preparations, as well as their ability to be easily applied locally to the affected mucosal surface, it is worth considering their use to reduce pain and dysphagia in the postoperative period in the upper respiratory tract. The study involved 77 patients who were randomly divided into 2 groups: patients taking a drug containing combined natural essential oils (CNEO) and patients taking a placebo. In the course of the study, a questionnaire was used, according to which patients were interviewed immediately after the operation, then on the 3rd and 10th postoperative days. The results of the study show that the drug does not directly reduce postoperative pain in the pharynx, but in patients in the group with the drug based on combined essential oils, the frequency of taking non-steroidal anti-inflammatory drugs (NSAIDs) was less than in patients in the placebo group, which indirectly proves the effectiveness of the drug based on combined essential oils. Given the fact that the frequency of NSAID use is lower in the CPNEM group, it can be assumed that the study drug reduces the risk of side effects caused by NSAID use, and can also be an alternative method of pain relief for patients who are contraindicated in NSAIDs.

scholarly journals Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Tong Wu ◽  
Sihan He ◽  
Zan Jiao ◽  
Xiang Liang ◽  
Yu Chen ◽  
...  
Keyword(s):  
Nasal Mucosa ◽  
Acute Sinusitis ◽  
Low Molecular Weight ◽  
Upper Respiratory Tract ◽  
Inflammatory Mechanism ◽  
Upper Respiratory ◽  
Anti Inflammatory ◽  
Experimental Group ◽  
Inflammatory Effect ◽  
Respiratory Tract Inflammation

Introduction: Low molecular weight heparin (LMWH), a natural sulfated glycosaminoglycan with an affinity for proangiogenic factors, is produced by chemical or enzymatic depolymerization of unfractionated heparin (UFH). Known for its anticoagulant effects, LMWH has recently been reported to have a strong anti-inflammatory effect on colitis, myocarditis, and airway inflammation. However, as a newly-developed drug, its anti-inflammatory mechanism in upper respiratory tract inflammation has not been well-studied.Methods: SD rats were randomly divided into control and experimental groups. The experimental group was established by building an acute nasal sinusitis model with expansion sponges mixed with Streptococcus pneumoniae. Then the experimental group rats were subcutaneously injected with different concentrations of LMWH. After seven consecutive days of injection, some rats were sacrificed, and blood and nasal mucosa samples were taken to determine their inflammation status. The remaining acute sinusitis rats were randomly selected for a week of nasal irrigation with normal saline or saline mixed with different concentrations of LMWH. One week later, rats were sacrificed, and samples of blood and nasal mucosa were taken to determine the inflammation status.Results: Rat nasal mucosa in the model group had obvious inflammation. The degree of nasal mucosa inflammation damage in the experimental group was lower than in the experimental control group, proving that LMWH has a protective effect on the nasal mucosa and that the effect correlates with dosage. Irrigation of the nose with saline mixed with LMWH can improve the anti-inflammatory effect. Protein related to the TLR4-MyD88-NF-κB signaling pathway was activated in the acute sinusitis rat model, and LMWH can significantly inhibit its expression.Conclusion: This is the first report of the anti-inflammatory effect of LMWH in acute upper respiratory tract inflammation, together with an explanation of its anti-inflammatory mechanism. The findings contribute a theoretical basis for its potential anti-tumor effect.

scholarly journals Modern approaches to the treatment of sore throat

2020 ◽  
pp. 31-34
Author(s):  
A. Yu. Ovchinnikov ◽  
N. A. Mirochnichenkо ◽  
V. A. Ekaterinchev
Keyword(s):  
Respiratory Tract ◽  
Upper Respiratory Tract ◽  
Local Inflammation ◽  
Protective Mechanisms ◽  
Vital Functions ◽  
Air Stream ◽  
Inflammatory Drugs ◽  
Upper Respiratory ◽  
Anti Inflammatory ◽  
Rapid Relief

The larynx is the first part of the respiratory and digestive tract and it performs vital functions. The air stream, passing through the throat and coming into contact with its mucous membrane, is moistened, warmed up and purified. Due to the anatomical structure of the mouth cavity and pharynx, it creates conditions for entry, presence and inactivation of microorganisms, viruses and fungi. Under normal conditions, due to effective protective mechanisms (mucociliary and immune), pathogens are trapped in the upper respiratory tract while the lower sections remain «clean». Acute pharyngitis is a widespread, polyetiological disease of the upper respiratory tract. There are quite a few preconditions for its development. A favorable background for local inflammation is the reduction of specific and non-specific protection factors, which may be observed in the existing chronic inflammation and worsened in diabetes mellitus and metabolic syndrome, with prolonged use of cytostatics and/or glucocorticosteroids and many other immunocompromised conditions. Due to the prevalence of pharyngitis, the development of effective screening and treatment methods is particularly relevant. Given the localized nature of inflammatory process in the pharynx and the possibility of side effects, general anti-inflammatory drugs are used less and less frequently, and local non-steroidal anti-inflammatory drugs are increasingly drawing the attention of physicians. The article discusses the possibilities and effectiveness of the medication based on benzidamine hydrochloride in treating pharyngitis of diverse etiology. The article presents the studies of foreign scientists, as well as dosages and peculiarities of the medication application. Treatment of acute tonsillipharyngitis with local non-steroidal anti-inflammatory drugs is commonly accepted and widely used in the practice of pediatricians, therapists and otorhinolaryngologists and allows to achieve rapid relief of the patient’s condition.

scholarly journals New possibilities of elimination-irrigation therapy drugs during the seasonal rise in the incidence of acute respiratory viral infections and influenza

2020 ◽  
Vol 64 (6) ◽  
pp. 110-113
Author(s):  
E. Yu. Radtsig
Keyword(s):  
Trace Elements ◽  
Viral Infections ◽  
Sea Water ◽  
Symptomatic Treatment ◽  
Upper Respiratory Tract ◽  
Treatment And Prevention ◽  
Upper Respiratory ◽  
Respiratory Viral Infections ◽  
Minerals And Trace Elements ◽  
Inflammatory Effect

Various methods and variants of nasal cavity irrigation are one of the most ancient in the treatment and prevention of diseases of the upper respiratory tract. When choosing a remedy for elimination and irrigation therapy, preference is given to preparations based on sea water, containing in its composition minerals and trace elements that cause additional therapeutic effect. A new direction in this type of therapy is the use of drugs containing fucoidans (obtained from brown algae extract). Their immunostimulatory and anti-inflammatory effect can improve the effectiveness of elimination and irrigation therapy in symptomatic treatment of ARVI / influenza and their complications (sinusitis, adenoiditis).

Anti-nociceptive and anti-inflammatory activity of synthesized novel benzoxazole derivatives

2021 ◽  
Vol 20 ◽  
Author(s):  
Mansi L. Patil ◽  
Swati S. Gaikwad ◽  
Naresh J. Gaikwad
Keyword(s):  
Cytotoxic Activity ◽  
Research Study ◽  
Ex Vivo ◽  
Immunological Response ◽  
Inflammatory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Introduction: Pain is an immunological response to any infection or inflammation and long term use of pain management therapy includes use of Nonsteroidal anti-inflammatory drugs which is associated with occurrence of toxicity as well as gastrointestinal bleeding. Therefore, the investigation of new analgesic and anti-inflammatory agents remains a major challenge. Aims: The objective of this research study is to undergo the pharmacological evaluation of newly synthesized benzoxazole derivatives. These novel derivatives were evaluated for anti-nociceptive, anti-inflammatory and cytotoxic activity using various in-vivo and ex-vivo methods. Methods: The study was carried out using swiss mice (adult male) weighing between 20gm to 30gm and were divided into groups containing (n=6) six animals in each group for treatment. The anti-nociceptive activity was performed by using 0.1ml of 0.6% v/v acetic acid as nociception inducer and evaluated by the diminished number of abdominal writhes. The anti-inflammatory activity was done using 0.1 ml of 2% w/v Carrageenan induced paw edema method was observed which was evaluated by calculating the percent maximum possible effect. Histopathological evaluation and cytotoxic activity of the compounds was carried out. Results: The results of this research study revealed that synthesized derivatives (a, b, c, d and e) showed promising anti-nociceptive and anti-inflammatory effect along significantly higher cytotoxic activity in MCF-7 cell lines. Conclusion: It can be concluded that synthesized derivatives (a, b, c, d and e) have potential anti-nociceptive and anti-inflammatory effect along with cytotoxic activity and certain modification in structure may result in potent activity.

scholarly journals The Effects of Vibration and Pressure Treatments in the Early Postoperative Period of Rhinoplasty

2019 ◽  
Vol 40 (6) ◽  
pp. 605-616 ◽  
Author(s):  
Süleyman Taş
Keyword(s):  
Postoperative Period ◽  
Early Postoperative Period ◽  
Control Group ◽  
Level Of Evidence ◽  
Vibration Treatment ◽  
The Face ◽  
Anti Inflammatory ◽  
Group 2 ◽  
A Prospective Study ◽  
Nasal Cast

Abstract Background The early postoperative period can be distressing for the patients undergoing rhinoplasty since edema and ecchymosis are common complications. Objectives To analyze the effects of the vibration and pressure treatments in the early postoperative period of rhinoplasty. Methods Sixty patients, who had undergone rhinoplasty, were randomized into 3 groups: group 1 (control group, n = 20) received classic nasal casting, group 2 (n = 20) received nasal cast with an elastic bandage to hold it on the face, and group 3 (n = 20) received vibration treatment in addition to that in group 2 following the rhinoplasty. They were evaluated preoperatively and postoperatively at 3 and 7 days in a prospective study. The postoperative edema and ecchymosis were scored by 2 independent surgeons. The postoperative pain was measured using the visual analog scale, and the necessity of anti-inflammatory medication (and the dose needed) and the cast comfort was questioned. The sebaceous activity of the nose skin was examined. A preoperative and postoperative seventh day sonographic study was performed to evaluate the tissue edema objectively. Results The pressure treatment decreased the edema and ecchymosis significantly compared with the control group. The vibration treatment minimized edema, ecchymosis, sebaceous activity of the nose skin, pain score, and the need for anti-inflammatory medication, and increased the cast comfort significantly compared with the other groups (P < 0.0001). Conclusions Rapid regression of edema and ecchymosis may be achieved using the vibrating nasal cast technique that may minimize patient discomfort, pain, and sebaceous activity following rhinoplasty. Level of Evidence: 1

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